Beskrivelse
BackgroundThe overgrowth of acid-tolerating species such as mutans streptococci is associated with caries. Accordingly, various anti-bacterial strategies have been suggested in the medical approach in the prevention of caries. Chlorhexidine is probably the most validated. However, a recolonisation of the mutans streptococci occurs quickly, hampering the expected anti-caries effect.
Aim
To evaluate whether daily use of lozenges containing probiotic bacteria could affect inhibit or delay the recolonisation of mutans streptococci in the oral cavity after a full-mouth disinfection with chlorhexdine.
Design
A multicentre, prospective study with a randomized, placebo-controlled double-blind design with two parallel arms. We enrolled 62 healthy young adults with high numbers of S. mutans. After a full-mouth disinfection with chlorhexidine the participants were given lozenges with either two strains of L. reuteri or placebo. The intervention period was 6 weeks and plaque samples and s. mutans counts were taken at baseline, 1 week, 6 weeks, 3 months and 6 months after the full-mouth disinfection.
Results
A statistically significant reduction of mutans streptococci after full-mouth disinfection with chlorhexidine was seen at 1 week, 3 weeks and 6 weeks in both groups. However, no statistical significance was seen between the groups.
Conclusions
Lozenges containing probiotic bacteria did not affect recolonisation of mutans streptococci after suppression with chlorhexidine.
| Periode | 12 maj 2011 |
|---|---|
| Begivenhedstitel | PhD Day, Faculty of Health |
| Begivenhedstype | Konference |
| Arrangør | University of Copenhagen |
| Placering | København, Danmark |