How broad spectrum antibiotic treatment of pregnant dams and young mice can alter hematopoiesis and the immune response to respiratory virus infection.

Beskrivelse

The overall aim of this project was to assess the effect of antibiotic treatments of mice to alter hematopoiesis and immune responses to viral infections.

Aim 1. To determine the effect of antibiotic treatment of pregnant dams on the composition of microbiota in pups and to characterize the adaptive immune response of pups to intranasal influenza virus challenge.

Aim 2: To determine the effect of antibiotic treatment of weanling mice (21 days) on the composition of microbiota and to characterize the adaptive immune response to intranasal influenza virus challenge.

Aim 3: To determine how long after removal of antibiotics it takes to restore microbiota and to characterize the adaptive immune response to intranasal influenza virus challenge after removal of antibiotics.

Together, these studies will provide information on the effects of indirect (i.e. treatment of pregnant dams) and direct (i.e. treatment of weanling mice) antibiotic treatment on microbiota and immune responses to viral
infection.

Periode	6 okt. 2014 → 16 maj 2015
Sted for afholdelse	University of Melbourne, Australien, Victoria