Özcan Met

E-mailozcanmetsund.kudk
Webstedhttps://isim.ku.dk/dansk/

Blegdamsvej 3B
2200 København N.
Blegdamsvej 3B
2200 København N

Publikationer pr. år

Primære forskningsområder

My current research focus is in the area of molecular and cellular tumor immunology, particularly the development of gene-engineered T cells, tailored to treat cancer:

(1) engineering of T cells with tumor-specific synthetic TCRs or chimeric antigen receptors (CARs) for adoptive immunotherapy (ACT)

(2) manipulate co-stimulatory pathways to improve expansion of tumor-resident tumor-infiltrating lymphocytes (TILs) enriched for tumor specificity

(3) genome editing using CRISPR/Cas9 to target cell-intrinsic pathways that restrict T-cell effector functions and their anti-tumor potential

(4) Development of isolation and expansion methods for TIL therapy and to produce large-scale GMP-grade TIL products for ACT clinical trials of melanoma and other solid tumors

Eksterne ansættelser

Director, Cell Production Unit, Copenhagen University Hospital - Rigshospitalet

1 sep. 2006 → …

Emneord

Det Sundhedsvidenskabelige Fakultet
Cancer Immunotherapy
CAR T cells
CRISPR/Cas9
Adoptive Cell Therapy
Genetic engineering

2786 Citationer
69 Tidsskriftartikel
4 Bidrag til bog/antologi
4 Review
1 Kommentar/debat
Mere
- 1 Letter

Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells
Glöckner, H. J., Martinenaite, E., Landkildehus Lisle, T., Grauslund, J., Ahmad, S., Met, Ö., Thor Straten, P. & Hald Andersen, M., 2024, I: OncoImmunology. 13, 1, 9 s., 2318053.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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1 Citationer (Scopus)
Reduced mitochondrial respiration in peripheral T cells after paediatric heamatopoietic stem cell transplantation
Mølgaard, K., Kielsen, K., Ifversen, M., Met, Ö., Svane, I. M. & Müller, K., 2024, I: Frontiers in Immunology. 14, 1327977.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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9 Downloads (Pure)
of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes
Hulen, T. M., Friese, C., Kristensen, N. P., Granhøj, J. S., Borch, T. H., Peeters, M. J. W., Donia, M., Andersen, M. H., Hadrup, S. R., Svane, I. M. & Met, Ö., 2023, I: Frontiers in Immunology. 14, 15 s., 1180997.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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1 Citationer (Scopus)

29 Downloads (Pure)
Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy
Mortensen, R. E. J., Holmström, M. O., Lisle, T. L., Hasselby, J. P., Willemoe, G. L., Met, Ö., Marie Svane, I., Johansen, J., Nielsen, D. L., Chen, I. M. & Andersen, M. H., 2023, I: Journal for ImmunoTherapy of Cancer. 11, 3
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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7 Citationer (Scopus)

26 Downloads (Pure)
Restoring tumor immunogenicity with dendritic cell reprogramming
Zimmermannova, O., Ferreira, A. G., Ascic, E., Santiago, M. V., Kurochkin, I., Hansen, M., Met, Ö., Caiado, I., Shapiro, I. E., Michaux, J., Humbert, M., Soto-Cabrera, D., Benonisson, H., Silvério-Alves, R., Gomez-Jimenez, D., Bernardo, C., Bauden, M., Andersson, R., Höglund, M., Miharada, K. & 9 flere, Nakamura, Y., Hugues, S., Greiff, L., Lindstedt, M., Rosa, F. F., Pires, C. F., Bassani-Sternberg, M., Svane, I. M. & Pereira, C. F., 2023, I: Science immunology. 8, 85, 20 s., eadd4817.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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11 Citationer (Scopus)
TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy
Tvingsholm, S. A., Frej, M. S., Rafa, V. M., Hansen, U. K., Ormhøj, M., Tyron, A., Jensen, A. W. P., Kadivar, M., Bentzen, A. K., Munk, K. K., Aasbjerg, G. N., Ternander, J. S. H., Heeke, C., Tamhane, T., Schmess, C., Funt, S. A., Kjeldsen, J. W., Kverneland, A. H., Met, Ö., Draghi, A. & 4 flere, Jakobsen, S. N., Donia, M., Marie Svane, I. & Hadrup, S. R., 2023, I: Journal for ImmunoTherapy of Cancer. 11, 8, 16 s., e006847.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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4 Citationer (Scopus)

7 Downloads (Pure)
Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV
Klausen, U., Grauslund, J. H., Jørgensen, N. G. D., Ahmad, S. M., Jonassen, M., Weis-Banke, S. E., Martinenaite, E., Pedersen, L. B., Lisle, T. L., Gang, A. O., Enggaard, L., Hansen, M., Holmström, M. O., Met, Ö., Svane, I. M., Niemann, C. U., Pedersen, L. M. & Andersen, M. H., 2022, I: Frontiers in Oncology. 12, 1023015.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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2 Citationer (Scopus)

25 Downloads (Pure)
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Weis-Banke, S. E., Lisle, T. L., Perez-Penco, M., Schina, A., Hübbe, M. L., Siersbæk, M., Holmström, M. O., Jørgensen, M. A., Marie Svane, I., Met, Ö., Ødum, N., Madsen, D. H., Donia, M., Grøntved, L. & Andersen, M. H., 2022, I: Journal for ImmunoTherapy of Cancer. 10, 10, e005326.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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5 Citationer (Scopus)

26 Downloads (Pure)

Özcan Met

Personlig profil

Primære forskningsområder

Eksterne ansættelser

Emneord

Samarbejde og topforskningsområder i de sidste fem år

Dyk ned i detaljerne

Arginase-1 specific CD8+ T cells react toward malignant and regulatory myeloid cells

Reduced mitochondrial respiration in peripheral T cells after paediatric heamatopoietic stem cell transplantation

of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes

Pre-existing TGF-β-specific T-cell immunity in patients with pancreatic cancer predicts survival after checkpoint inhibitors combined with radiotherapy

Restoring tumor immunogenicity with dendritic cell reprogramming

TCR-engaging scaffolds selectively expand antigen-specific T-cells with a favorable phenotype for adoptive cell therapy

Anti-PD-L1/PD-L2 therapeutic vaccination in untreated chronic lymphocytic leukemia patients with unmutated IgHV

Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells