Personlig profil
Kort præsentation
Prof. Anja Groth is director of the Center for Epigenetic Cell Memory at the Danish Cancer Institute,the Danish Cancer Society. She a professor and reserach director at the the Novo Nordisk Foundation Center for Protein Research (CPR), Dept of Cellular & Molecular Medicine (ICMM), Faculty of Health and Medical Sciences, University of Copenhagen. Anja Groth received her PhD in Molecular Biology from the University of Copenhagen in 2004 for her research in the laboratory of Drs. Lukas and Bartek. She did her postdoctoral training from 2005 to 2007 with Dr. Almouzni at Institut Curie, Paris, focusing on histone dynamics during DNA replication. In 2008 Dr. Groth started as a junior group leader at BRIC, supported by a Junior Group Leader Fellowship from the Lundbeck Foundation. She was tenured in 2013 and promoted to professor in 2016. Prof. Anja Groth has received several prestigious awards, including the Danish Research Council Young Elite Researcher Prize (2009), the Danish Cancer Society Junior Research Prize (2011), the Heirloom Award for Women Scientist Leaders (2014), the Elite Research Prize by the Danish Ministry of Higher Education and Science (2018) and Queen Margrethe II's Research Prize (2020). She was elected as a member of the Royal Danish Academy of Sciences and Letters in 2016 and EMBO in 2017, and she is among the few who has received ERC Starting, Consolidator and Advanced grants. The scientific focus of Anja Groth is epigenetic cell memory, chromatin replication and the interplay between genome and epigenome stability. Her research group has contributed with seminal discoveries on histone chaperone function, chromatin replication mechanisms, inheritance of histone post-translational modifications and DNA repair pathway choice. The Groth group has a strong record track in collaborative interdisciplinary research and developing new tailored technologies to address chromatin replication and epigenetic cell memory (NCC-proteomics, ChOR-seq, SCAR-seq, and repli-ATAC-seq). In 2018, Prof. Groth founded Ankrin Therapeutics, a drug discovery company with the aim to develop new targeted cancer therapy based on her discovery of a new chromatin-linked DNA repair mechanism. In 2020, Anja Groth moved her research group to CPR and became director of the Protein Memory research program focused on protein-based epigenetic memory. In 2025, she moved her group to the Danish Cancer Institute to establish a Center of Excellence in Epigenetic Cell Memory with support from the Danish National Research Foundation.
Interesseområder
- Epigenetics
- Genome maintenance
- Cancer biology
- Aging
Primære forskningsområder
- Histone metabolism
- Chromatin replication
- Epigenetic cell memory
- Genome stability and cancer
CV
Appointments
Current
2025 -
Director, Danish National Research Foundation Center for Epigenetic Cell Memory (start 08/2025)
2025 -
Group leader, Danish Cancer Institute, Danish Cancer Society
2023 -
Co-affiliated Professor, Dept. Cellular and Molecular Medicine (ICMM), Faculty of Health and Medical Sciences, University of Copenhagen
2020 -
Program director for the Protein Memory program, Novo Nordisk Foundation Center for Protein Research (CPR) at University of Copenhagen
2020 -
Professor, Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen
2020 -
Co-affiliation, Biotech and Research Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
Previous
2018 - 2025
Co-founder and CSO of the biotech company Ankrin Therapeutics
2016 - 2019
Professor, Biotech and Research Innovation Centre (BRIC), Faculty of Health and Medical Sciences, University of Copenhagen
2017 -2019
Co-affiliation, Novo Nordisk Foundation Center for Protein Research (CPR) at University of Copenhagen
2013 - 2016
Tenured group leader, Biotech Research and Innovation Centre
2008 - 2013
Associate Professor and group leader, Biotech Research and Innovation Centre
2005 - 2008
Postdoc, Laboratory of Dr. G. Almouzni, Chromatin Dynamics, Institut Curie, Paris, France
2004 - 2005
Postdoc, Laboratory of Drs. J. Bartek & J. Lukas, Danish Cancer Society, Copenhagen
Awards and selected grants
2024 Danish National Research Foundation Center of Excellence Grant
2024 ERC Advanced Grant (no. 101142230)
2022 Lundbeck Foundation Scientific Enrichment Prize
2021 NNF Distinguished Investigator Award
2020 Queen Margrethe II's Research Prize
2018 Elite Research Prize, the Danish Ministry of Higher Education and Science
2017 Elected EMBO member
2017 ERC Consolidator Grant (no. 724436)
2016 Member of the Royal Danish Academy of Science and Letters (Natural Sciences)
2014 Heirloom Award for Women Scientist Leaders, UK
2012 Junior Research Prize, Danish Cancer Society
2012 World Cultural Council Special Recognition
2011 ERC Starting Grant (no. 281765)
2011 EMBO Young Investigator program (YIP)
2009 Young Elite Researcher prize, Danish Research Council
2009 Award for Young Researchers, Danish Biotechnology Society
2007 Junior Group Leader Fellowship, The Lundbeck Foundation
Education
2004 PhD, Molecular Biology, University of Copenhagen. Laboratory of Drs. J. Bartek & J. Lukas, Danish Cancer Society, Copenhagen
2000 M.Sc., Biochemistry, University of Copenhagen. Laboratory of Dr. B. M. Willumsen, University of Copenhagen, and Drs. C. J. Sherr & M. F. Roussel, St. Jude Children's Research Hospital, USA
Eksterne ansættelser
CSO, Ankrin Therapeutics
1 feb. 2019 → …
Samarbejde og topforskningsområder i de sidste fem år
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Chromatin replication and epigenetic cell memory
Stewart-Morgan, K. R., Petryk, N. & Groth, A., 2020, I: Nature Cell Biology. 22, s. 361-371Publikation: Bidrag til tidsskrift › Review › peer review
Åben adgangFil216 Citationer (Scopus)441 Downloads (Pure) -
Transcription Restart Establishes Chromatin Accessibility after DNA Replication
Stewart-Morgan, K. R., Reverón-Gómez, N. & Groth, A., 2019, I: Molecular Cell. 75, 2, s. 284-297 20 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
60 Citationer (Scopus) -
MCM2 promotes symmetric inheritance of modified histones during DNA replication
Petryk, N., Dalby, M., Wenger, A., Stromme, C. B., Strandsby, A., Andersson, R. & Groth, A., 2018, I: Science. 361, 6409, s. 1389-1392 3 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil221 Citationer (Scopus)919 Downloads (Pure) -
Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication
Reverón-Gómez, N., González-Aguilera, C., Stewart-Morgan, K. R., Petryk, N., Flury, V., Graziano, S., Johansen, J. V., Jakobsen, J. S., Alabert, C. & Groth, A., 2018, I: Molecular Cell. 72, 2, s. 239-249 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil185 Citationer (Scopus)431 Downloads (Pure) -
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Saredi, G., Huang, H., Hammond, C. M., Alabert, C., Bekker-Jensen, S., Forne, I., Reverón-Gómez, N., Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, N., Imhof, A., Patel, D. J. & Groth, A., 30 jun. 2016, I: Nature. 534, 7609, s. 714-8 5 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
177 Citationer (Scopus) -
A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks
Huang, H., Strømme, C. B., Saredi, G., Hödl, M., Strandsby, A., González-Aguilera, C., Chen, S., Groth, A. & Patel, D. J., 2015, I: Nature Structural and Molecular Biology. 22, 8, s. 618-626 9 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
190 Citationer (Scopus) -
Two distinct modes for propagation of histone PTMs across the cell cycle
Alabert, C., Barth, T. K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O. N., Imhof, A. & Groth, A., 15 mar. 2015, I: Genes & Development. 29, 6, s. 585-90 6 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
318 Citationer (Scopus) -
Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components
Alabert, C., Bukowski-Wills, J.-C., Lee, S.-P., Kustatscher, G., Nakamura, K., de Lima Alves, F., Menard, P., Mejlvang, J., Rappsilber, J. & Groth, A., 23 feb. 2014, I: Nature Cell Biology.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
305 Citationer (Scopus)