Personlig profil
Kort præsentation
Staphylococcus aureus is the leading cause of bacterial infections in developed countries and Methicillin-Resistant S. aureus (MRSA) is one of the most significant antibiotic resistant bacteria world-wide. For this reason, my research is dedicated to unravel the molecular mechanisms underlying the ability of Staphylococcus aureus to cause disease and to develop antibiotic resistance. Focus has been on the highly conserved ClpP proteases and Clp chaperones that we have shown to be absolutely essential for the virulence of Staphylococcus aureus. We are currently investigating how the Clp proteases and chaperones central activities such as:
- Virulence gene regulation
- Antibiotic resistance
- Cell division
The long-term objective of my research is to provide the scientific basis for the development of drugs interfering with these mechanisms.
CV
Academic Degrees
cand. scient (1994) University of Copenhangen; Ph. D. (2000) KVL, Department of Food Science
Employments
2000-2003 Assistant professor at the Department of Veterinary Microbiology (KVL).
2003-present Associate professor at the Department of Veterinary Pathobiology KVL (from January the 1 st 2007 KU)
Emneord
- Det Sundhedsvidenskabelige Fakultet
Samarbejde og topforskningsområder i de sidste fem år
Publikation
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Cell splitting in Staphylococcus aureus is controlled by an adaptor protein facilitating degradation of a peptidoglycan hydrolase
Barbuti, M. D., Skjennum, E. F., Mebus, V. H., Angeles, D. M., Hustad, M., Mårli, M. T., Frees, D. & Kjos, M., 2025, I: PLOS Genetics. 21, 30 s., e1011841.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil1 Citationer (Scopus)10 Downloads (Pure) -
Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance
Bejaoui, S., Nielsen, S. H., Rasmussen, A., Coia, J. E., Andersen, D. T., Pedersen, T. B., Møller, M. V., Kusk Nielsen, M. T., Frees, D. & Persson, S., 2025, I: BMC Genomics. 26, 15 s., 92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil20 Citationer (Scopus)19 Downloads (Pure) -
Multiple highly resistant clones of MRSA circulating among patients with skin and soft tissue infection, Peshawar, Pakistan 2021–2022
Ullah, A., Frees, D., Mansoor, M., Jamal, S. F. & Tkadlec, J., 2025, I: Epidemiology and Infection. 153, 7 s., e113.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil12 Downloads (Pure) -
Temperature-dependent regulation of bacterial cell division hydrolases by the coordinated action of a regulatory RNA and the ClpXP protease
Mebus, V. H., Busch, L. M., Børre, M., Nielsen, T. K., Bojer, M. S., Henriksen, C., Barbuti, M. D., Angeles, D. M., Brejndal, K., Michalik, S., Salazar, M. G., Kjos, M., Völker, U., Kallipolitis, B. H. & Frees, D., 2025, I: Cell Surface. 13, 16 s., 100144.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil2 Citationer (Scopus)54 Downloads (Pure) -
The ClpXP protease and the ClpX unfoldase control virulence, cell division, and autolysis in Streptococcus pneumoniae
Mebus, V. H., De, S., Busch, L. M., Salazar, M. G., Schlüter, R., Völker, U., Hammerschmidt, S. & Frees, D., 2025, I: Microbiology Spectrum. 13, 7, 22 s., e00804-25.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil2 Citationer (Scopus)15 Downloads (Pure) -
Unraveling proteomic chaos by independent component analysis-ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior
Busch, L. M., Wolfgramm, H., De, S., Hentschker, C., Gesell Salazar, M., Kröber, M., Hopp, C., Illenseher, M. S., Ganske, A., Michalik, S., Reder, A., Hammerschmidt, S., Frees, D., Gerth, U., Surmann, K., Mäder, U. & Völker, U., 2025, I: mSystems. 10, 12, 30 s., e0109225.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil4 Downloads (Pure) -
Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool
Olsen, J. E., Frees, D., Kyvsgaard, N. C. & Barco, L., 2024, I: Letters in Applied Microbiology. 77, 2, 9 s., ovae015.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division
Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, D., 2024, I: Molecular Microbiology. 121, 1, s. 98-115Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil6 Citationer (Scopus)58 Downloads (Pure)
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The ClpP proteases control processes of vital importance for the pathogenesis of Staphylococcus aureus
Frees, D. (Foredragsholder)
3 okt. 2007Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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Regulated proteolysis controls vital processes in Staphylococcus aureus
Frees, D. (Foredragsholder)
5 sep. 2007Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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Synthesis and activity of the alternative sigma factor, SigB is serely reduced in Staphylococcus aureus cells lacking the ClpP protease
Frees, D. (Foredragsholder)
23 maj 2007Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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A possible role of ClpP proteases and chaperones in regulating activity of SigmaB
Frees, D. (Foredragsholder)
23 jan. 2007Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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FEMS Microbiology Letters (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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Journal of Applied Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning
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FEMS Immunology & Medical Microbiology (Tidsskrift)
Frees, D. (Redaktør)
1 jan. 2007Aktivitet: Peer-review og redaktionelt arbejde - typer › Peer reviewer/fagfællebedømmer af manuskripter › Forskning