Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
From Vancouver, Canada
BRIDGE fellow (Sept 2022-present), Department of Drug Design and Pharmacology, University of Copenhagen. Mentors: Drs. Niels H. Skotte and Jørgen E. Nielsen (Rigshospitalet). Project: Delineating neuroglial communication in health and Huntington's disease
Postdoc (Sept 2020-Aug 2022), Department of Drug Design and Pharmacology, University of Copenhagen. Supervisor: Prof. Hans Bräuner-Osborne, in collaboration with LF Prof. Shohreh Issazadeh-Navikas at BRIC. Project: In vivo role of GPR15 in T-cell mediated inflammation
PhD (MoMeD, Sept 2016-Oct 2021), Biotech Research and Innovation Centre, University of Copenhagen. Supervisor: Prof. Shohreh Issazadeh-Navikas, Project: Type-I interferon signaling in CNS homeostasis and Parkinson's disease dementia
Research technician, Centre of Molecular Medicine and Therapeutics (2012-2015). Supervisors: Drs. Michael Hayden and Amber Southwell. Projects: Behavioural and neuropathological charaterization of preclinical Huntington's disease mouse models
MSc in Biology, University of British Columbia Okanagan (2011). Supervisor: Dr. Andis Klegeris. Project: Impact of a glial-secreted proinflammatory phospholipase on neuronal health
BSc in Honours Health Studies, University of Waterloo (2008)
Primære forskningsområder
Neuroinflammation, Neurodegeneration, Parkinson's disease, Huntington's disease
Uddannelse (Akademiske kvalifikationer)
Biology, Master of Science, Department of Biology, University of British Columbia Okanagan
2 jan. 2009 → 30 apr. 2011
Dimissionsdato: 30 apr. 2011
Eksterne ansættelser
Research Technician, Centre for Molecular Medicine and Therapeutics at BC Children's Hospital Research, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.
5 feb. 2012 → 15 dec. 2015
Emneord
- BRIC
Samarbejde og topforskningsområder i de sidste fem år
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Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice
Villanueva, E. B., Tresse, E., Liu, Y., Duarte, J. N., Jimenez-Duran, G., Ejlerskov, P., Kretz, O., Loreth, D., Goldmann, T., Prinz, M. & Issazadeh-Navikas, S., 2021, I: Annals of Neurology. 90, 5, s. 789-807Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil2 Citationer (Scopus)66 Downloads (Pure) -
ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT
Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., sep. 2018, s. A91-A91.Publikation: Konferencebidrag › Poster › Forskning
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HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 jan. 2018, I: Human Molecular Genetics. 27, 2, s. 239-253 15 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
26 Citationer (Scopus) -
Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease
Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, I: Science Translational Medicine. 10, 461, s. 1-12 eaar3959.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
94 Citationer (Scopus) -
A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles
Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 flere, , 15 mar. 2017, I: Human Molecular Genetics. 26, 6, s. 1115-1132 18 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
25 Citationer (Scopus) -
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes
Southwell, A. L., Smith-Dijak, A., Kay, C., Sepers, M., Villanueva, E. B., Parsons, M. P., Xie, Y., Anderson, L., Felczak, B., Waltl, S., Ko, S., Cheung, D., Dal Cengio, L., Slama, R., Petoukhov, E., Raymond, L. A. & Hayden, M. R., 1 sep. 2016, I: Human Molecular Genetics. 25, 17, s. 3654-3675 22 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
70 Citationer (Scopus) -
Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease
Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., Jonason, A., Felczak, B., Zhang, W., Kovalik, V., Waltl, S., Hall, G., Pouladi, M. A., Smith, E. S., Bowers, W. J., Zauderer, M. & Hayden, M. R., apr. 2015, I: Neurobiology of Disease. 76, s. 46-56 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
86 Citationer (Scopus) -
Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease
Villanueva, E. B., Little, J. P. & Klegeris, A., 30 nov. 2015, Recent Advances in Medicinal Chemistry. Atta-ur-Rahman, Choudhary, M. I. & Perry, G. (red.). Bentham Science Publishers, s. 59-75Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review