Erika Villanueva

Søgeresultater

• 2021

  Neuronal TNFα, not α-syn, underlies PDD-like disease progression in IFNβ-KO mice

  Villanueva, E. B., Tresse, E., Liu, Y., Duarte, J. N., Jimenez-Duran, G., Ejlerskov, P., Kretz, O., Loreth, D., Goldmann, T., Prinz, M. & Issazadeh-Navikas, S., 2021, I: Annals of Neurology. 90, 5, s. 789-807

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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  2 Citationer (Scopus)

  66 Downloads (Pure)
• 2018

  ANTIBODIES INHIBIT CELL TO CELL TRANSMISSION OF MUTANT HTT

  Bartl, S., Oueslati, A., Southwell, A. L., Parth, M., Salhat, N., Siddu, A., Burkert, M., Pankevych, H., David, L., Villanueva, E. B., Xie, Y., Dal Cengio, L., Ko, S., Hayden, M. R., Cicchetti, F. & Smrzka, O. W., sep. 2018, s. A91-A91.

  Publikation: Konferencebidrag › Poster › Forskning

• HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

  Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. & Hayden, M. R., 15 jan. 2018, I: Human Molecular Genetics. 27, 2, s. 239-253 15 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  26 Citationer (Scopus)

• Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

  Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, I: Science Translational Medicine. 10, 461, s. 1-12 eaar3959.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  95 Citationer (Scopus)
• 2017

  A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

  Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 flere, Seth, P. P. & Hayden, M. R., 15 mar. 2017, I: Human Molecular Genetics. 26, 6, s. 1115-1132 18 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  25 Citationer (Scopus)
• 2016

  An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

  Southwell, A. L., Smith-Dijak, A., Kay, C., Sepers, M., Villanueva, E. B., Parsons, M. P., Xie, Y., Anderson, L., Felczak, B., Waltl, S., Ko, S., Cheung, D., Dal Cengio, L., Slama, R., Petoukhov, E., Raymond, L. A. & Hayden, M. R., 1 sep. 2016, I: Human Molecular Genetics. 25, 17, s. 3654-3675 22 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  72 Citationer (Scopus)
• 2015

  Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

  Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., Jonason, A., Felczak, B., Zhang, W., Kovalik, V., Waltl, S., Hall, G., Pouladi, M. A., Smith, E. S., Bowers, W. J., Zauderer, M. & Hayden, M. R., apr. 2015, I: Neurobiology of Disease. 76, s. 46-56 11 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  86 Citationer (Scopus)

• Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinson's Disease

  Villanueva, E. B., Little, J. P. & Klegeris, A., 30 nov. 2015, Recent Advances in Medicinal Chemistry. Atta-ur-Rahman, Choudhary, M. I. & Perry, G. (red.). Bentham Science Publishers, s. 59-75

  Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review

• Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

  Southwell, A. L., Smith, S. E. P., Davis, T. R., Caron, N. S., Villanueva, E. B., Xie, Y., Collins, J. A., Ye, M. L., Sturrock, A., Leavitt, B. R., Schrum, A. G. & Hayden, M. R., 15 jul. 2015, I: Scientific Reports. 5, s. 12166

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  79 Citationer (Scopus)
• 2014

  In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

  Southwell, A. L., Skotte, N. H., Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, E. B., Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., dec. 2014, I: Molecular Therapy. 22, 12, s. 2093-106 14 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  114 Citationer (Scopus)

• Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia

  Little, J. P., Simtchouk, S., Schindler, S. M., Villanueva, E. B., Gill, N. E., Walker, D. G., Wolthers, K. R. & Klegeris, A., maj 2014, I: Molecular and Cellular Neuroscience. 60, s. 88-96 9 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  59 Citationer (Scopus)
• 2013

  A fully humanized transgenic mouse model of Huntington disease

  Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, N. H., Zhang, W., Villanueva, E. B., Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 jan. 2013, I: Human Molecular Genetics. 22, 1, s. 18-34 17 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  82 Citationer (Scopus)

• Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

  Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, N. H., Doty, C. N., Vaid, K., Villanueva, E. B., Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., nov. 2013, I: Nucleic Acids Research. 41, 21, s. 9634-50 17 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  129 Citationer (Scopus)
• 2012

  Secreted phospholipase A2 group IIA is a neurotoxin released by stimulated human glial cells

  Villanueva, E. B., Little, J. P., Lambeau, G. & Klegeris, A., 2012, I: Molecular and Cellular Neuroscience.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  20 Citationer (Scopus)
• 2011

  Cultured adult porcine astrocytes and microglia express functional interferon-γ receptors and exhibit toxicity towards SH-SY5Y cells

  Ionescu, V. A., Villanueva, E. B., Hashioka, S., Bahniwal, M. & Klegeris, A., 28 feb. 2011, I: Brain Research Bulletin. 84, 3, s. 244-51 8 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  11 Citationer (Scopus)

• Moderate increase in temperature may exacerbate neuroinflammatory processes in the brain: human cell culture studies

  Bahniwal, M., Villanueva, E. B. & Klegeris, A., apr. 2011, I: Journal of Neuroimmunology. 233, 1-2, s. 65-72 8 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  7 Citationer (Scopus)

• Therapeutic Potential of Cannabinoids in the Treatment of Neuroinflammation Associated with Parkinsons Disease

  Little, J. P., Villanueva, E. B. & Klegeris, A., 1 jun. 2011, I: Mini-Reviews in Medicinal Chemistry.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

• Therapeutic potential of cannabinoids in the treatment of neuroinflammation associated with Parkinson's disease

  Little, J. P., Villanueva, E. B. & Klegeris, A., jun. 2011, I: Mini reviews in medicinal chemistry. 11, 7, s. 582-90 9 s.

  Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
  24 Citationer (Scopus)
• 2010

  Synthesis and biological evaluation of novel pyrazole compounds

  Youssef, A. M., Neeland, E. G., Villanueva, E. B., White, M. S., El-Ashmawy, I. M., Patrick, B., Klegeris, A. & Abd-El-Aziz, A. S., 1 aug. 2010, I: Bioorganic & Medicinal Chemistry. 18, 15, s. 5685-96 12 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  41 Citationer (Scopus)

• Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents

  Youssef, A. M., White, M. S., Villanueva, E. B., El-Ashmawy, I. M. & Klegeris, A., 1 mar. 2010, I: Bioorganic & Medicinal Chemistry. 18, 5, s. 2019-28 10 s.

  Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
  106 Citationer (Scopus)