Publikationer pr. år
Publikationer pr. år
Personlig profil
Primære forskningsområder
Forensic genetic applications of mitochondrial DNA (mtDNA)
Aktuel forskning
- MitoMetrics: Incorporation of mtDNA profile discrepancies in likelihood ratio calculations.
- mtDNA analysis from shotgun sequencing data.
- Validation and implementation of mtDNA analysis from telogen hair and cartridge samples.
Kort præsentation
The use of mitochondrial DNA (mtDNA) in forensic genetics has proven to be an important tool in the analysis of trace samples where nuclear DNA is degraded and/or present in low amounts. However, the interpretation and reporting of mtDNA still face challenges, particularly regarding inclusion/exclusion scenarios in inclusive cases and the reporting of heteroplasmy. With the emergence of massively parallel sequencing and shotgun sequencing, the threshold for detecting and reporting mtDNA heteroplasmy is changing and becoming more sensitive. My work focuses on enhancing the implementation of mtDNA in forensic casework.
Uddannelse (Akademiske kvalifikationer)
Molecular Genetics, MSc., Whole mitogenome variations in the Kenyan population through nanopore sequencing, University of Leicester
sep. 2021 → sep. 2022
Dimissionsdato: 20 jan. 2023
Forensic Science, BSc., Implementation of a quality control tool (qBiCo) for the assessment of bisulfite conversion in DNA methylation profiling, Amsterdam University of Applied Sciences
sep. 2017 → jun. 2021
Dimissionsdato: 8 jul. 2021
Eksterne ansættelser
Graduate student researcher - Genetics, University of Leicester
jan. 2022 → sep. 2022
Research Assistant in Epigenetics, Erasmus University Rotterdam
jun. 2021 → jul. 2021
Undergraduate student researcher - Epigenetics, Erasmus University Rotterdam
feb. 2021 → jun. 2021
Intern - Forensic Science, Dutch National Police
sep. 2019 → jan. 2020
Emneord
- Det Sundhedsvidenskabelige Fakultet
- Mitochondrial DNA
- mtDNA Haplogroups
- Massive Parallel Sequencing (MPS)
- Population Genetics
- Forensic Genetics
- DNA
- Genetics
- MPS
- Shotgun sequencing
- Heteroplasmy
Samarbejde og topforskningsområder i de sidste fem år
Seneste eksterne samarbejde på lande-/områdeniveau. Dyk ned i detaljerne ved at klikke på prikkerne eller
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Long-read, high-throughput sequencing of 10,000 human mitogenomes using the PacBio Sequel IIe
Holland, M. M., McElhoe, J. A., Holland, C. A., Khosa, J. K., Alcaide, C. P., Hannon, D., Brownfield, E. D., Korber, J. T., Foster, M. G., Cundey, R. T., Claessens, F., Higginbotham, J., Anderson, E., Sturk-Andreaggi, K., Marshall, C. & Parson, W., 2027, I: Forensic Science International: Genetics. 87, 11 s., 103588.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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MitoMetrics: Incorporation of mtDNA profile discrepancies in likelihood ratio calculations
Claessens, F., Andersen, M. M., Amory, C., Arévalo, C., Desmyter, S., Dognaux, S., van der Gaag, K. J., Grzybowski, T., Huber, G., Melchionda, F., Nakanishi, H., Olsen, T., Pie, C., Prieto, L., Skonieczna, K., Turchi, C., Parson, W. & Pereira, V., 2026, I: Forensic science international. Genetics. 84, 103477.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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qBiCo: a method to assess global DNA conversion performance in epigenetics via single-copy genes and repetitive elements
Karkala, F., Simons, R. B., Claessens, F. A. J., Kalamara, V., Kayser, M. & Vidaki , A., 2025, I: Epigenetics Communications. 5, 2, 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Comparison of DNA Extraction Methods for Telogen Hair Samples
Bie Petersen, C., Claessens, F. A. J., Farzad, M. S., Mogensen, H. S., Børsting, C. & Kampmann, M.-L., 2024, ISFG 2024 - abstract book. s. 151-151 P-371Publikation: Bidrag til bog/antologi/rapport › Konferenceabstrakt i proceedings › Forskning › peer review
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Mitochondrial DNA heteroplasmy patterns in hair shaft samples: Insights from Whole Mitogenome Sequencing using the Precision ID mtDNA Whole Genome Panel
Claessens, F. A. J., Farzad, M. S., Parson, W., Børsting, C. & Pereira, V., 2024, ISFG 2024 - abstract book. s. 142-142 P-309Publikation: Bidrag til bog/antologi/rapport › Konferenceabstrakt i proceedings › Forskning › peer review
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MitoMetrics: Characterisation of mitochondrial DNA heteroplasmy in hair shafts and its incorporation on likelihood ratio calculations
Pereira, V., Claessens, F. A. J., Amory, C., Arévalo, C., Desmyter, S., van der Gaag, K., Grisedale, K., Grzybowski, T., Huber, G., Melchionda, F., Nakanishi, H., Oluffa Stenberg Olsen, T., Pie, C., Prieto, L., Skonieczna, K., Turchi, C., Ward, J., Andersen, M. M. & Parson, W., 2024, ISFG 2024 - abstract book. s. 476-476 P-180Publikation: Bidrag til bog/antologi/rapport › Konferenceabstrakt i proceedings › Forskning › peer review
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New Forensic (Epi)genetic Frontiers
Claessens, F. A. J. (Inviteret foredragsholder) & Vidaki, A. (Inviteret foredragsholder)
11 dec. 2025Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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Police Expert Network on Missing Persons 2025
Claessens, F. A. J. (Inviteret foredragsholder)
9 dec. 2025 → 11 dec. 2025Aktivitet: Deltagelse i arrangement eller begivenhed - typer › Deltagelse i workshop, seminar og kursus
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MitoMetrics: Incorporation of mtDNA profile discrepancies in likelihood ratio calculations
Claessens, F. A. J. (Oplægsholder)
3 dec. 2025Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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Gordon Research Conference on Forensic Analysis of Human DNA
Claessens, F. A. J. (Deltager)
22 jun. 2025 → 27 jun. 2025Aktivitet: Deltagelse i arrangement eller begivenhed - typer › Deltagelse i workshop, seminar og kursus
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Gordon Research Seminar on Forensic Analysis of Human DNA
Claessens, F. A. J. (Deltager)
21 jun. 2025 → 22 jun. 2025Aktivitet: Deltagelse i arrangement eller begivenhed - typer › Deltagelse i workshop, seminar og kursus
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30th Congress of the International Society for Forensic Genetics.
Claessens, F. A. J. (Deltager)
9 sep. 2024 → 13 sep. 2024Aktivitet: Deltagelse i arrangement eller begivenhed - typer › Deltagelse i workshop, seminar og kursus
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A Comprehensive Analysis of Whole Mitogenome Heteroplasmy Patterns in Different Forensic Tissues
Claessens, F. A. J. (Oplægsholder), Farzad, M. S. (Andet), Parson, W. (Andet), Børsting, C. (Andet) & Alves E Silva Pereira, V. (Andet)
19 jun. 2024Aktivitet: Præsentationer, medlemskaber og andre aktivitetstyper › Foredrag og mundtlige bidrag
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13th ISABS Conference
Claessens, F. A. J. (Taler)
17 jun. 2024 → 20 jun. 2024Aktivitet: Deltagelse i arrangement eller begivenhed - typer › Deltagelse i workshop, seminar og kursus
Priser
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Moses Schanfield Young Investigator Award
Claessens, F. A. J. (Modtager), jun. 2024
Pris: Priser, stipendier, udnævnelser