Publikationer pr. år
Publikationer pr. år
Blegdamsvej 3B, 2200 København N
Publikationer pr. år
Cancer develops in a complex mutational landscape. Cancer cells accumulate ‘driver mutations’ that are causally linked to disease, and ‘passenger mutations’ that, although present, have limited impact on disease. In recent years, factors encoded by cancer genes have become targets for successful anticancer drug development. Although cancer genome sequence data provide an unparalleled depth of information about the mutations present in different cancer genomes, identification of genetic alterations contributing to tumorigenesis and metastasis calls for the use of simple genetic model systems.
We have engineered Drosophila strains that activate different cancer-driver mutations. These flies allow, with a single genetic cross, the introduction of new mutations to identify genes that, when combined with driver mutations, lead to tumor formation and metastasis.
Specific aims
(1) understand how different mutations cooperate during the process of cellular transformation
(2) study the oncogenic potential of epithelial tetraploid cells that result from cytokinesis failure
(3) better understand how the metabolic changes taking place in cancer cells contribute to cellular transformation and metastasis
(4) determine the role that miRNAs play in growth control during normal development and cancer
Analysis of gene functions in development and disease, using Drosophila
Héctor Herranz, PhD
Department of Cellular and Molecular Medicine (ICMM) University of Copenhagen, Denmark
[email protected]
Education
2002 PhD. University Autónoma of Madrid, Spain 1997 Degree in Biochemistry. University of Salamanca, Spain 1996 Degree in Biology. University of Salamanca, Spain
Research Appointments
2014- | Associate Professor, Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen, Denmark |
2010-2014 | Research Fellow, Institute of Molecular and Cell Biology, Singapore |
2010 | Research Fellow, Temasek Life Sciences, Singapore |
2004-2009 | Postdoctoral Fellow, Institute for Research in Biomedicine, Spain |
2002-2004 | Postdoctoral Fellow, Molecular Biology Centre (CBM)/University Autónoma of Madrid, Spain |
1997-2002 | PhD studies, Centre of Molecular Biology (CBM)/University Autónoma of Madrid, Spain |
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Leder › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review