Kort præsentation

Technical barriers have left the glycomics field under-explored with a huge potential for discovery and biomedical applications. We are developing novel enabling technologies to overcome these barriers using a genetic approach to glycomics. Our unique strategies to glycomics are based on a genetic entry point and designed for open-ended and opportunistic Ome-wide discovery. The grand idea is to transform glycosciences from a field largely only approachable to specialists into a mainstream “Omics” field approachable to non-specialists with an ease comparable to the genome and proteome fields today. Our specific discovery programs GlycoDisplay, GlycoCRISPR, GlycoDesign, and GlycoView are developing unique reagents, tools and community resources that will help bring glycosciences into a new phase where studying the biology of glycans becomes as intuitive as building with “Lego”.

Primære forskningsområder

Henrik Clausen forsker i de sukkerstoffer der beklæder alle proteiner i naturen. Han har viden om og deltaget i udviklingen af den proces, der kan omdanne blodtyperne A, B og AB til blodtype O. Henrik Clausen har desuden viden om biomarkører for cancer, cancer-associerede kulhydrater og mikroarrays. Han leder Copenhagen Center for Glycomics, der udvikler et stort glykopeptid-bibliotek, repræsenterende cancer-associerede glykoformer af membrane glykoprotiner, som vil blive printet på mikroarray slides og anvendt til at påvise antistoffer mod cancer-antigener hos cancer patienter. Målet er at identificere autoantistof signaturer som sensitive og specifikke markører for cancer.

Aktuel forskning

Lundbeck Foundation funded program (2017-19) to develop an innovative cell-based platform to display all human glycans individually in an arrayable format. Such a library of genetically engineered cells with different glycans will enable high throughput screening and discovery of glycan functions in the natural context of the cell. The glycan cell library is sustainable and addressable by any multiplex assay format.

CV

Work address:	ICMM, Mærsk Tower, The Panum Institute, 7.10.21, University of Copenhagen Blegdamsvej 3, DK-2200, Denmark
E-mail:	[email protected]
1981:	DDS, School of Dentistry, Faculty of Health Sciences, Copenhagen
1990:	Dr.odont (D.Sc.) School of Dentistry, Faculty of Health Sciences, Copenhagen
Academic appointments
1981-82:	Intern, Danish Navy, general practitioner
1982-86:	Research fellow, School of Dentistry, Faculty of Health Sciences, Copen­hagen.
1983-86:	Visiting research fellow, Fred Hutchinson Cancer Research Center, Program of Biochemical Oncology and University of Washington, Seattle, USA.
1986-90:	Research assistant professor, University of Washington, Seattle, USA.
1986-90:	Head of Department of Immunogenetics, The Biomembrane Institute, Seattle, USA.
1990-91:	Associate professor (lektor), Department of Oral Diagnostics, School of Dentistry, Faculty of Health Sciences, Copenhagen, Denmark.
1991-04:	Senior associate professor (docent), Department of Oral Diagnostics, School of Dentistry, Faculty of Health Sciences, Copenhagen, Denmark.
1994-98:	Member of the Scientific Advisory board of Aptein Inc, USA
1998-	Member of General Scientific Advisory board of Neose Inc, USA
2000-	Consultant, ZymeQuest Inc, USA
2000-05	Visiting Lecturer on Pathology, BIDMC, Harvard Medical School, USA
2001-	Member of GlycoAdvance Scientific Advisory board of Neose Inc, USA
2001-	National representative in IGO, International Glycoconjugate Organization
2002	Consultant, Millennium Pharmaceuticals, USA
2005-	Professor, Institute of Cellular and Molecular Medicine, Copenhagen, Denmark

Prizes

• The Benzow Prize (1994)
• The Thureus Prize (1998)
• Mizutani Prize (1999)
• The Carlsberg Biotechnology Prize (2008) 

Editorial

• Editorial board of Glycoconjugate J (1995-)
• Editorial board of J. Biol.Chem. (2004-)

Organization Conferences (organiser, co-organiser, session chair)

Benzon Symposia #36, Copenhagen (1993), Nordic Glycobiology Symposia, Copenhagen (1992, 1994, 1996, 1998, 2000, 2001, 2004), International Cancer-Associated Mucin Workshop, Cambridge/Crete (1994, 1996, 1998, 2000, 2003, 2005, 2007, 2009), International workshop on mucin glycosylation, Copenhagen (1997), XIII International Symposium on Glycoconjugates, Zürich (1997), Symposium on carbohydrate and immunity, Lesbos (1997, 1999), Congress of the International Society of Blood Transfusion, Oslo (1998), International Workshop on Glycosylation and Immunity, Greece (2001), Glycosyltransferases in the New Millennium, Toronto (2000), Gordon Conference on Glycobiology, Ventura, Los Angeles (2001), International Glycosyltransferase Symposium, Stockholm (2002), International Glycosyltransferase Symposium, Le Touquet (2004), International Glycosyltransferase Symposium, Tsukuba, Japan (2006). International Glycosyltransferase Symposium, Atlanta, USA(2008).Benzon Symposium #54, Copenhagen (2007).