Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
The research interest of H Nielsen group is RNA biology with emphasis on catalytic RNA and epitranscriptomics.
Primære forskningsområder
Epitranscriptomics with emphasis on specialized ribosomes in the immune system, during development, and in cancer. Ribozymes, RNA splicing and small non-coding RNA molecules.
Aktuel forskning
- The flexibility and evolutionary adaptability of RNA-guided nucleotide modifications
- Specialized ribosomes (including cancer ribosomes)
- The role of helicases in ribosome biogenesis
- New RNA cap structures
- The lariat capping ribozyme
- Characterization of the circularization pathway in group I introns
CV
Name: Henrik Nielsen Born: November 25, 1955 in Copenhagen, Denmark
Address: Stenløsevej 18, 2700 Brønshøj, Denmark
education/degrees
• Cand. scient. (Masters) in Molecular Biology, University of Copenhagen (1983). • Lic. scient. (PhD) in Molecular Biology, University of Copenhagen (1990).
honors
"Teacher of the year 1998" at the Health Science Faculty, University of Copenhagen.
positions/fellowships:
| Aug. 1984 - Febr. 1991 | University fellowships and fellowship from the Danish Research at Dept. of Biochemistry,Univ.of Copenhagen. |
| Aug. 1988 - Nov. 1988 | Scientific adviser on TV-production ("Den Nye Arv"), DR-TV and Univ. of Copenhagen. |
| Febr. 1991 - Jan. 1995 | Assistant Professor, Dept. of Biochemistry,Univ.of Copenhagen. |
| Febr. 1995 – Sept. 2009 | Associate Professor, Dept. of Biochemistry (now Dept. of Cellular and Molecular Medicine),Univ.ofCopenhagen. |
| July 2004 - June 2008 | Associate Professor 2, Dept. of Molecular Biotechnology, Univ. of Tromsø, Norway |
| October 2009 - | Professor MSO, Dept. of Cellular and Molecular Medicine, Univ. of Copenhagen. |
| November 2009 - December 2021 | Professor 2, Universities in Tromsø and Bodø, Norway (totaling 9 years). |
Key research topics: Epitranscriptomics with emphasis on specialized ribosomes in the immune system, during development, and in cancer. Ribozymes, RNA splicing and small non-coding RNA molecules.
Present networks: InnControl funded by The Research council of Norway and COST network Translacore.
Main collaborators: Anders Lund (BRIC, Copenhagen), Kirsten Grønbæk and Fazila Asmar (Copenhagen), Markus Bohnsack (Göttingen), Jérôme Cavaillé (Toulouse), Carsten Geisler (Copenhagen), Steinar D. Johansen (Bodø), Peter Brodersen (Copenhagen), and Ferdinand von Walden (Stockholm).
Emneord
- Det Sundhedsvidenskabelige Fakultet
- RNA biology
- Functional genomics
- Epitranscriptomics
- Ribozymes
- Lariat capping
Samarbejde og topforskningsområder i de sidste fem år
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GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners
Kanwal, N., Krogh, N., Memet, I., Lemus-Diaz, N., Thomé, C. C., Welp, L. M., Mizi, A., Hackert, P., Papantonis, A., Urlaub, H., Nielsen, H., Bohnsack, K. E. & Bohnsack, M. T., 2024, I: Nucleic Acids Research. 52, 4, s. 1953-1974 22 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic stimulus
Cui, M., Jannig, P., Halladjian, M., Figueiredo, V. C., Wen, Y., Vechetti, I. J., Krogh, N., Jude, B., Edman, S., Lanner, J., McCarthy, J., Murach, K. A., Sejersen, T., Nielsen, H. & von Walden, F., 2024, I: American Journal of Physiology - Cell Physiology. 327, 3, s. C516-C524 9 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Making ends meet: a universal driver of large ribosomal subunit biogenesis
Bohnsack, K. E., Henras, A. K., Nielsen, H. & Bohnsack, M. T., 2023, I: Trends in Biochemical Sciences. 48, 3, s. 213-215Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Ribosomal RNA 2′-O-methylation dynamics impact cell fate decisions
Häfner, S. J., Jansson, M. D., Altinel, K., Andersen, K. L., Abay-Nørgaard, Z., Ménard, P., Fontenas, M., Sørensen, D. M., Gay, D. M., Arendrup, F. S., Tehler, D., Krogh, N., Nielsen, H., Kraushar, M. L., Kirkeby, A. & Lund, A. H., 2023, I: Developmental Cell. 58, 17, s. 1593-1609.e9Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Fil18 Citationer (Scopus)38 Downloads (Pure) -
Fractional 2'-O-methylation in the ribosomal RNA of Dictyostelium discoideum supports ribosome heterogeneity in Amoebozoa
Diesend, J., Birkedal, U., Kjellin, J., Zhang, J., Jablonski, K. P., Söderbom, F., Nielsen, H. & Hammann, C., 2022, I: Scientific Reports. 12, 1952.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Stool Microbiota Diversity Analysis of Blastocystis-Positive and Blastocystis-Negative Individuals
Stensvold, C. R., Sorland, B. A., Berg, R. P. K. D., Andersen, L. OB., van der Giezen, M., Bowtell, J. L., El-Badry, A. A., Belkessa, S., Kurt, O. & Nielsen, H. V., 2022, I: Microorganisms. 10, 2, 6 s., 326.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Regulation of translation by site-specific ribosomal RNA methylation
Jansson, M. D., Häfner, S. J., Altinel, K., Tehler, D. E., Krogh, N., Jakobsen, E., Andersen, J. V., Andersen, K. L., Schoof, E., Ménard, P., Nielsen, H. & Lund, A. H., 2021, I: Nature Structural and Molecular Biology. 28, 11, s. 889-899Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Fil55 Citationer (Scopus)48 Downloads (Pure) -
RNA helicase-mediated regulation of snoRNP dynamics on pre-ribosomes and rRNA 2'-O-methylation
Aquino, G. R. R., Krogh, N., Hackert, P., Martin, R., Gallesio, J. D., van Nues, R. W., Schneider, C., Watkins, N. J., Nielsen, H., Bohnsack, K. E. & Bohnsack, M. T., 2021, I: Nucleic Acids Research. 49, 7, s. 4066-4084 19 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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