• Kilde: Scopus
20072024

Publikationer pr. år

Personlig profil

Kort præsentation

The Kloverpris laboratory is interested in the mechanisms underlying gut immune reconstitution following injury or damage after HIV infection. To perform these studies, we have developed unique and well-characterized human tissue cohorts in areas of South Africa home to the highest HIV prevalence in the world.

Primære forskningsområder

The gut has the largest outward-facing surface area in the body. It is home to the majority of our immune and bacteria cells that exist in a complex interplay with our tissue cells. Gut homeostasis, critical for overall health, is disrupted in people living with HIV (PLWH) and plays an essential role in HIV-associated pathology not restored by long-term antiretroviral therapy (ART). Although ART significantly reduces mortality and prolongs the life of PLWH, the ageing worldwide population on ART is entering higher-risk age groups for non-communicable diseases (NCDs), including diabetes and hypertension. This represents a looming new healthcare burden, particularly in countries with limited healthcare resources.

Throughout my career, I have worked at the interface of clinical medicine and basic science and established a research programme that take advantage of the unique patient and research cohorts to generate high-impact, clinically relevant discovery science. At the Africa Health Research Institute (AHRI) in Durban, South Africa and at the University of Copenhagen, we utilise these unique and well-defined cohorts to study intestinal mucosal and lymphoid tissues in participants from areas with the highest HIV prevalence in the world. This is a great opportunity to make discoveries in PLWH that genuinely impact our understanding of health and disease in low-middle income settings. The Kloverpris lab collaborates globally and has made a series of findings on the effect of HIV infection on gut homeostasis and immune function focused on optimising immune reconstitution in PLWH.

CV

EDUCATION

2007 – 2011
PhD Immunology (HIV)
Medical Sciences Division,Oxford University, UK
Health Sciences, Immunology and Microbiology, University of Copenhagen, DK

2004 – 2007
MSc, Immunology, Health Sciences, Immunology and Microbiology, University of Copenhagen, DK

2001 – 2003
BSc Microbiology, Natural Sciences, Biochemistry, University of Copenhagen, DK

 

POSITIONS
2021 – present
Faculty, Africa Health Research Institute (AHRI), South Africa

2016 – present
Associate Professor, University of Copenhagen, Immunology and Microbiology, DK

2016 – present
Sir Henry Dale Wellcome Trust, University College London (UCL), UK

2017 – 2021
Junior Faculty, Africa Health Research Institute (AHRI), South Africa

2013 – 2016
Post Doc, Africa Health Research Institute (AHRI), South Africa

2011 – 2013
Post Doc, Medical Sciences Division, Oxford University, UK

 

AWARDS
2016 – 2022
Wellcome Trust, Henry Dale Wellcome Trust Fellow, UK

2015 – 2016
Danish Council for Independent Research, Sapere Aude, DK

2012 – 2015
Danish Council for Independent Research, DK. Post doc fellowship.

 

GRANTS
2021 – 2026
NIH (UM1AI164566) Co-I (PI Deborah Persaud), John Hopkins, US. Title: ‘Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory’.

2020 – 2025
NIH (R01DK126545) NIDDK Co-PI (33%) (PI Douglas Kwon) MIT, US. Title: ‘Mechanisms of HIV-associated epithelial intestinal stem cell (ISC) dysfunction’.

2019 – 2022
AHRI grant (R63) PI Title: Feasibility of gut biopsy collection from participants in the Somkhele surveillance area to determine intestinal microbiome and immune dysregulation associated with HIV infection.

2016 – 2019
South African Network for TB&HIV Excellence (SANTHE) PI Title: Function of HIV specific killer T-cells in human tissue from infected people to achieve HIV cure

2013 – 2015
Lundbeck Foundation, Denmark PI Title: Acute HIV specific CD8+ T-cell responses in durable immune control.

2009 – 2018
MAERSK (8 awards)

 

INVITED SPEAKER
2022
Australian Centre for HIV and Hepatitis Virology, Canberra, Australia (Keynote)
PERSIMUNE – Basic and Translational, Copenhagen HIV Programme (CHIP), DK
Human Cell Atlas (HCA), Africa Symposium
ENT Symposium, Inkosi Albert Luthuli Central Hospital, Durban, South Africa

2021
Research Day, University of Kentucky, US

2020
Human Cell Atlas (HCA), Africa Symposium
Wellcome Trust Meeting, Sanger Institute, Hinxton, UK

2019
Annual assembly on viral infections, SSI, Denmark (Keynote), DK

2018
Annual Meeting Immunology and Infectious Diseases, Helsingør, DK

2016
Irsi Caxia, HIV research center, Barcelona, Spain
US military HIV research program, Bethesda, US
Institute for HIV Research, Professor Hendrik Streeck, Essen, Germany

2015
A-Star, Science Technology and Research, Biopolis, Immunos, Singapore

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