Personlig profil
Kort præsentation
Janine Erler is a Group Leader at BRIC, University of Copenhagen. She graduated as BSc with Honours in Molecular Genetics from the University of Sussex (UK) in 2000 and was awarded a PhD in Molecular Pharmacology from the University of Manchester (UK) in 2003 for her research on hypoxia-regulated resistance of cancer cells to chemotherapy. Between 2004 and 2008, Dr Erler was a postdoctoral training fellow in the laboratory of Prof Amato Giaccia at Stanford University (USA), where she started working on hypoxia-regulated metastasis and identified lysyl oxidase (LOX) as a key mediator. She then started her own independent research group in 2008 at the Institute of Cancer Research in London (UK). Dr Erler moved her lab to BRIC in 2012. She has received numerous awards for her research including the BACR Translational Research Award (2009) and the BACR/AstraZeneca Young Scientist Frank Rose Award (2012), and was the first woman to receive the prestigious Novo Nordisk Hallas Møller Stipendum (2012).
Primære forskningsområder
Cancer Biology
Tumour Microenvironment
Metastasis
Translational Research
CV
EDUCATION
2000-2003 University of Manchester, UK, School of Biological Sciences
PhD Molecular Pharmacology: “The impact of tumour hypoxia on drug-induced apoptosis”
1996-2000 University of Sussex, UK, School of Biological Sciences
BSc (Hons) 1st Class, Molecular Genetics in Biotechnology (with Industrial Placement)
1989-1996 The European School, Culham, Oxfordshire, UK
European Baccalaureate: 13 subjects, 7.9 (out of 10) overal
RECENT WORK EXPERIENCE
2012-present Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark
Group Leader, tumour microenvironment
2008-2012 The Institute of Cancer Research, London, UK, Division of Cancer Biology
Team Leader, hypoxia and metastasis
2004-2008 Stanford University, USA, Department of Radiation Oncology
Postdoctoral Fellow, hypoxia and metastasis
1998-1999 AstraZeneca Pharmaceuticals, Cheshire, UK,
Cardiovascular Metabolism and Musculoskeletal Research
Industrial Placement student, researching obesity
1995 Bayer AG, Leverkusen, Germany
Summer student, biotechnology research
Samarbejde og topforskningsområder i de sidste fem år
Publikation
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Immune Cell Modulation of Patient-Matched Organoid Drug Response in Precision Cancer Medicine Platform
Kjølle, S., Presti, M., Roque, J. D. P., Bisgaard, L. H., Ramos, D. B., Zornhagen, K. W., Yde, C. W., Schmidt, A. Y., Verdys, P., Højgaard, M., Lassen, U., Svane, I. M., Rohrberg, K. S., Donia, M. & Erler, J. T., jan. 2026, I: Cells.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Immune Cell Modulation of Patient-Matched Organoid Drug Response in Precision Cancer Medicine Platform
Kjølle, S., Presti, M., Roque, J. D. P., Bisgaard, L. H., Beceiro Ramos, D., Zornhagen, K. W., Yde, C. W., Schmidt, A. Y., Verdys, P., Højgaard, M., Lassen, U., Svane, I. M., Rohrberg, K. S., Donia, M. & Erler, J. T., 29 jan. 2026, I: Cells. 15, 3Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
1 Citationer (Scopus) -
Crosstalk between tumor endothelial cells and cancer cells is important for metastasis initiation
Oria, V. O., Castro, J. L., de Pina Roque, J., Martinez, A. G., Jørgensen, F. I., Lukassen, M. V., Rib, L., Høg, M. K. G., Mygind, K. J. & Erler, J. T., 2025, I: Cell Communication and Signaling. 23, 1, 21 s., 443.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Exercise boost after surgery improves survival in model of metastatic breast cancer
Stagaard, R., Jensen, A., Schauer, T., Bay, M. L., Tavanez, A. R., Wielsøe, S., Peletier, M., Strøbech, J. E., Oria, V. O., Zornhagen, K. W., Albrechtsen, R., Christensen, J. F. & Erler, J. T., 2025, I: Frontiers in Immunology. 16, 13 s., 1533798.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil7 Citationer (Scopus)13 Downloads (Pure) -
Loss of nidogen-1 causes lung basement membrane defects and increased metastasis
Xia, T., Zornhagen, K. W., Miinalainen, I., Abramovitz, L., Madsen, C. D., Nicolau, M., Mayorca-Guiliani, A. E., Erez, N. & Erler, J. T., 2025, I: Frontiers in Immunology. 16, 10 s., 1598547.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Machine learning identifies remodeling patterns in human lung extracellular matrix
Emerson, M. J., Willacy, O., Madsen, C. D., Reuten, R., Brøchner, C. B., Lund, T. K., Dahl, A. B., Jensen, T. H. L., Erler, J. T. & Mayorca-Guiliani, A. E., 2025, I: Acta Biomaterialia. 195, s. 94-103 10 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
2 Citationer (Scopus) -
Murine Cell Line Models for Vascular Mimicry: The Role of YAP/TAZ Signaling
Righetti, M., Primorac, A. M., Erler, J. T. & Oria, V. O., 2025, I: International Journal of Molecular Sciences. 26, 18, 17 s., 9129.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins
Mygind, K. J., Nikodemus, D., Gnosa, S., Kweder, R., Albrechtsen, N. J. W., Kveiborg, M., Erler, J. T. & Albrechtsen, R., 2024, I: International Journal of Molecular Sciences. 25, 11, 15 s., 5871.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil5 Citationer (Scopus)31 Downloads (Pure)