Publikationer pr. år
Publikationer pr. år
Personlig profil
Kort præsentation
My research aims to characterize the structural and functional mechanisms of human aquaporins (AQPs). AQPs are water transporting pores engulfed in the plasma membrane of the cells. AQPs can be divided into three subgroups: orthodox AQPs, aquaglyceroporins, and super AQPs. The orthodox AQPs consist of AQP0,1,2,4,5,6 and 8 and are responsible for simple water transport. The aquaglyceroporins consist of AQP3,7,9 and 10, which, besides water, are also responsible for glycerol transport among other small solutes. Lastly, the super AQPs share low sequence similarity to the other AQPs, and their function and mechanism are today the least investigated of the three subgroups, while only minimal functional data has been published. To date orthodox AQPs have been extensively investigated, but zero structures of the human aquaglyceroporins and super AQPs have been reported.
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Publikation
- 528 Citationer
- 13 Tidsskriftartikel
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The role of phosphorylation in calmodulin-mediated gating of human AQP0
Kreida, S., Roche, J. V., Missel, J. W., Al-Jubair, T., Hagströmer, C. J., Wittenbecher, V., Linse, S., Gourdon, P. & Törnroth-Horsefield, S., 2024, I: The Biochemical journal. 481, 1, s. 17-32 16 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil3 Citationer (Scopus)3 Downloads (Pure) -
Assessing water permeability of aquaporins in a proteoliposome-based stopped-flow setup
Steffen, J. H., Missel, J. W., Al-Jubair, T., Kitchen, P., Salman, M. M., Bill, R. M., Törnroth-Horsefield, S. & Gourdon, P., 2022, I: STAR Protocols. 3, 2, 11 s., 101312.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil1 Citationer (Scopus)23 Downloads (Pure) -
Characterization of human aquaporin protein-protein interactions using microscale thermophoresis (MST)
Al-Jubair, T., Steffen, J. H., Missel, J. W., Kitchen, P., Salman, M. M., Bill, R. M., Gourdon, P. & Törnroth-Horsefield, S., 2022, I: STAR Protocols. 3, 2, 8 s., 101316.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil2 Citationer (Scopus)24 Downloads (Pure) -
High-yield overproduction and purification of human aquaporins from Pichia pastoris
Al-Jubair, T., Steffen, J. H., Missel, J. W., Kitchen, P., Salman, M. M., Bill, R. M., Gourdon, P. & Törnroth-Horsefield, S., 2022, I: STAR Protocols. 3, 2, 19 s., 101298.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil2 Citationer (Scopus)22 Downloads (Pure) -
PcoB is a defense outer membrane protein that facilitates cellular uptake of copper
Li, P., Nayeri, N., Górecki, K., Becares, E. R., Wang, K., Mahato, D. R., Andersson, M., Abeyrathna, S. S., Lindkvist-Petersson, K., Meloni, G., Missel, J. W. & Gourdon, P., 2022, I: Protein Science. 31, 7, s. 1-16 e4364.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil5 Citationer (Scopus)22 Downloads (Pure) -
The role of water coordination in the pH-dependent gating of hAQP10
Truelsen, S. F., Missel, J. W., Gotfryd, K., Pedersen, P. A., Gourdon, P., Lindorff-Larsen, K. & Hélix-Nielsen, C., 2022, I: B B A - Biomembranes. 1864, 1, 13 s., 183809.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
3 Citationer (Scopus) -
Cyclohexyl-alpha maltoside as a highly efficient tool for membrane protein studies
Missel, J. W., Salustros, N., Becares, E. R., Steffen, J. H., Laursen, A. G., Garcia, A. S., Garcia-Alai, M. M., Kolar, C., Gourdon, P. & Gotfryd, K., 2021, I: Current Research in Structural Biology. 3, s. 85-94 10 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil3 Citationer (Scopus)18 Downloads (Pure) -
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema
Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., Al-Jubair, T., Winkel Missel, J., Gourdon, P., Törnroth-Horsefield, S., Conner, M. T., Ahmed, Z., Conner, A. C. & Bill, R. M., 2020, I: Cell. 181, 4, s. 784-799Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil300 Citationer (Scopus)69 Downloads (Pure)