Curriculum Vitae for Kresten Lindorff-Larsen (May 2023)

Google Scholar ID: IQ59QNUAAAAJ; ORCID: 0000-0002-4750-6039; Researcher ID: K-6469-2014

Positions held

07/2016 –    Professor, Structural Biology and NMR Laboratory, Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen (UCPH)

2011–16      Assoc. Prof., Structural Biology and NMR Laboratory, Dept. Bio., UCPH

2007–11      Senior Scientist, D. E. Shaw Research, New York, U.S.A.

2005–07      Assistant Professor, Department of Biochemistry, UCPH

2004–05      EMBO Research Fellow, Dept. of Protein Chem., UCPH

2001            Protein chemist, Maxygen Aps, Denmark

Education

2001–4        Ph.D. studies at the University of Cambridge and St. John’s College, U.K. Supervisor: Sir Christopher M Dobson

1994–2000  Studies in Biochemistry (cand. scient.). UCPH.

Selected Awards and Grants

2023            ERC Synergy Grant DynaPLIX (One of three PIs)

2022            Integrative Structural Biology course—Novo Nordisk Foundation (PI)

2022            Twinning for Excellence: TWIN2PIPSA (Horizon Europe; co-PI)

2019            PRISM centre (Novo Nordisk Foundation Challenge Programme) (Director)

2019            Infrastructure for NMR and Computing (Novo Nordisk Foundation) (co-PI)

2016            BRAINSTRUC (Lundbeck Foundation initiative) (Director since 2017)

2012            Sapere Aude Starting Grant—Danish Council for Independent Research (PI)

2011            Hallas-Møller Stipend —Novo Nordisk foundation (PI)

2009            Co-recipient of the 2009 Gordon Bell Prize

2006            Danish Independent Research Councils’ Young Researchers’ Award

Selected University Administration

2013–now   Head of Biocomputing Core Facility, Dept. Bio., UCPH

2015–18      Member of the Strategic Research Unit, Dept. Bio., UCPH (Chair 2017–18)

2013–18      Member of the Departmental Council, Dept. Bio., UCPH

Selected Organisational Work

2020–now   Panel Member Independent Research Fund Denmark | Natural Sciences

2020–now   Panel Member DeiC Science Forum and Computerome science panel

2018–2021  Panel Member ERC Advanced Grant

2011–now   Grant and promotion evaluations for multiple international universities and organizations

2011–16      Founding member of the Young Academy of Denmark

2013–now   Organizer of several international conferences (Berlin, Zürich, Boston)

Teaching and Supervision

2005–now   Teaching and course organization at all levels in protein chemistry and biophysics

2005–now   Supervisor and mentor for ca. 100 B.Sc., M.Sc., PhD students, and post docs

Research Focus

I am an interdisciplinary scientist and our research combines biochemistry, biophysics and structural biology to tackle fundamental problems in biology. We focus on developing and applying methods that combine experiments with computational modelling. Our research topics bridge from basic to applied science, and I have experience working both in academia and industry.

We have established a unique and highly cross-disciplinary research environment, where we currently focus on two research areas. First, we integrate molecular simulations with structural biology to study the structure and dynamics of proteins. Second, we combine high-throughput experiments and methods from cell biology with computational biophysics and data science to problems in genomic medicine. We focus on developing mechanistic models and understanding of variant effects in disease.

Our work bridges across scientific disciplines. Within the field of structural biology, we use molecular simulations to interpret biophysical experiments on protein structure and dynamics. including combining experiments and simulations to study disordered proteins. We have also helped establish approaches to link biophysics, machine learning, cell biology and genomics. Common to these areas is a drive to understand biology at the molecular level, with the goal to solve problems of practical importance.

Publications, Conferences and Outreach

• Co-author of 185 peer-reviewed scientific publications. Full list here.
• Invited speaker at >50 international conferences and ca. 50 seminars.
• Popular science articles e.g. on Parkinson’s disease (2006), genome editing (2017), effects of mutations (2021), protein structure prediction (2021) and interviews
• Popular science lectures e.g. “Mød Videnskaben” (2012; UCPH/Politiken), “DUA Peptalk” (2014; Young Academy of Denmark), “Forskningens Døgn” (2014; Royal Danish Academy of Sciences;), “Fra protein-struktur og folding til patientdiagnose” (2017; DeiC Conference)

Kresten Lindorff-Larsen trained as a biochemist at the University of Copenhagen and Carlsberg Laboratory, and completed his Ph.D. at the University of Cambridge in 2004 under the supervision of Prof. Christopher M. Dobson. He then moved on to become an assistant professor in Copenhagen before joining D. E. Shaw Research in New York in 2007. He returned to Copenhagen in 2011, where he now serves as a Professor of Computational Protein Biophysics at the Linderstrøm-Lang Centre For Protein Science. He received the Danish Independent Research Councils’ Young Researchers’ Award in 2006, was a co-recipient of the 2009 Gordon Bell Prize and has received several prestigious grants including a Hallas-Møller stipend (2011), a Sapere Aude starting grant (2012), and most recently a Novo Nordisk Foundation challenge programme grant (2019). He was the director of the Lundbeck Foundation BRAINSTRUC initiative in structural biology and is the director the Novo Nordisk Foundation PRISM (Protein Interactions and Stability in Medicine and Genomics) centre. He is also PI in the ERC Synergy grant DynaPLIX (2023). Current research interests include developing and applying computational methods for integrative structural biology and protein dynamics, and the integration of biophysics and genomics research.