Billede af Lars Erik Larsen
  • Kilde: Scopus
20002024

Publikationer pr. år

Personlig profil

Kort præsentation

Lars Erik Larsen (født 1963) er professor i veterinær virologi og har arbejdet med virusinfektioner i produktionsdyr i de sidste 20 år. Han har været involveret i forskning i svinevira (diagnostiske værktøjer, molekylær epidemiologi, vaccinologi og basal patogenese) i de sidste 15 år. Lars har deltaget i adskillige nationale og europæiske projekter om enzootiske svinevirus med fokus på PRRSV, PCV-2 og svineinfluenzavirus. Han er leder af forskningsgruppen for enzootisk / zoonotisk virus ved UCPH og er videnskabeligt ansvarlig for det nationale overvågningsprogram for virus af aviær influenza og svin og er formand for det danske ekspertudvalg for aviær influenza og Newcastle Disease. Lars er også ansvarlig for undervisningen af ​​veterinærstuderende i veterinær virologi og er vejleder for en række ph.d.-, kandidat- og bachelorstuderende. Lars er i øjeblikket bestyrelsesmedlem i Dansk Selskab for Virologi. Han har offentliggjort mere end 100 internationale peer review-artikler om veterinær virologi og har medforfatter til mere end 300 andre publikationer.

Aktuel forskning

 

Gruppens forskningsmæssige kerneområde er influenzavirus i fugle og svin. Forskningen er fokuseret på udredningen af de faktorer, der afgør om et givet influenza-isolat kan smitte mennesker (zoonotiske aspekter), og hvilke virale determinanter, der er ansvarlig for, at virus kan forårsage alvorlig sygdom. 

Gruppen var således de første til at demonstrere distributionen og sammensætningen af influenza A virus receptorer i svin. Gruppen deltager endvidere i EU og nationale projekter vedrørende andre vigtige virusinfektioner som PRRSV, Hepatitis E, diarre hos svin, virus hos kalve, fjerkræ, mink og vildt samt innovationsprojekter vedrørende udvikling anvendelse af vacciner til forebyggelse af sygdomme hos produktionsdyr

Forskningsaktiviteterne foregår både i cellekulturer og i dyremodeller. Et reverse genetic system til manipulation af influenzavirus er etableret, og gruppen anvender såvel konventionel som NGS (Next Generation Sequencing) til detaljerede analyser af virusevolution.

Forskningen inden for influenzavirus er essentiel for forskningsmæssigt at understøtte et forudseende veterinært beredskab og en opdateret diagnostisk portefølje i Dansk veterinær Konsortium samtidig med at resultaterne bidrager med vigtig ny viden, der kan anvendes direkte i vurderingen af den zoonotiske risiko af fremtidige nye influenzavirus.

Forskningen indenfor almindeligt forekommende (enzootisk) virusinfektioner foregår i tæt samarbejde med og delvist finansieret af organisationerne Landbrug & Fødevarer, SEGES samt Danish Fur og bidrager til at fastholde Danmarks konkurrenceevne inden for den animale produktion ligesom forskningen bidrager til forbedret dyrevelfærd, højere produktivitet, samt en bedre fødevaresikkerhed.

CV

Personal information

Name:             Lars Erik Larsen

Born:               February 18, 1963 in Horsens; Denmark

Private:            Home address: Parkvej 7a 3550 Slangerup

Private status              Two kids (Simon from 1996 and Stefan from 1998)

Nationality:                 Danish

Current position:         Professor

Work address:          Department of Veterinary and Animal Sciences

Faculty of Health and Medical Sciences

University of Copenhagen

Dyrlægevej 88

1870 Frederiksberg C

Education (Academic Qualifications)

1991                D.V.M.; The Royal Veterinary and Agricultural University, Denmark

1998                Ph.D.; The Royal Veterinary and Agricultural University, Denmark

2008                 Diplomate of European College of Porcine Health Management (Dipl. ESPHM)

Awards

2002                O. Jensen's Memorial Award for work on BRSV in calves

2008                European PCV2 Award; Boehringer Ingelheim, Germany

2019                European PRRSV Award;      Boehringer Ingelheim, Germany       

 

Employment

Jan 1991 - Aug 1991            Visiting Research Scientist, Iowa State University; USA

Aug 1991 - Oct 1993           Study director, Scantox A/S, Ll. Shendsved; Denmark

Oct 1993 - Oct 2004            Senior Scientist Nycomed Imaging, Oslo, Norway

Nov 1994 - Dec 1997           Ph.d. Scholarship: Department of Veterinary Microbiology, RVAU, DK

Dec 1997 - Dec 2000           Research Scientist, Danish Veterinary Laboratory, Copenhagen, Denmark

Jan 2001 - May 2003           Senior Research Scientist, Danish Veterinary Laboratory, Copenhagen, DK

May 2003 - Dec 2003           Senior Scientist, Department of Virology, Novonordisk A/S, Bagsværd, DK

Jan 2004 - Jan 2009             Head of Section, National Veterinary Institute, DK

Aug 2010 - 2019                  Professor, National Veterinary Institute; DTU, DK

2019- present                      Professor, IVH, KU, DK

Teaching Experience and Censorships

2001-    Member of evaluation committees at minimum 15 bachelor, master and PhD exams at KU-LIFE

2001-    Co-advisor for 25 master students at DTU-VET and KU

2005-    Member of PhD evaluation committees in Sweden; Spain, Norway and Belgium

2006-    Main supervisor for 10 PhD students

2010-    Study responsible and main teacher of ”Virology for Veterinary Students”

 

Publications

103 peer reviewed; more than 300 others. H index:  27 (5 years calculated by Scholar august 2018). Total citations 1041 (938 without self citations). 19 citations/paper on average (Scorpus 2018). Research areas: Viral pathogenesis; Molecular epidemiology; vaccine development and assessment; development of diagnostic methods. Wild birds, poultry, swine, cattle, mink.

Full list of publications: ORCID: 0000-0003-0730-5555.

 Management experience/education

In 2004, I was appointed Head of Section of Pathology, Molecular Microbiology and Virology at the Division of Veterinary Diagnostic and Research. From 2004-2006, I was responsible for personnel management, budgets, work safety etc. of 27 employees including 6 senior scientists, 8 post docs/PhD students and 13 lab technicians. This position constituted 50% of my time, including participation in the management team of the division.

In 2007-2008, the pathology group constituting 9 employees was transferred to another section. From 2009, I was responsible for the virus research and diagnostic development group which constituted me, 3 post docs/scientists; 3 PhD students and 5 lab technicians. From August 2014, I have been responsible for the research group, which presently consist of one post doc, one molecular biologist, three PhD students and lab technicians. 

In addition to my practical experience with (line) management, I have passed the exam of the first two courses of the certified Danish “Diploma in Management” education.

I have several years of experience as scientific project manager of small and large research projects with participation from several different institutions and countries. In addition, I have had the scientific responsibility for the virus group at DTU-VET since 1998. Finally, I have completed a formal education in project management provided by the former Ministry of Food and Agriculture.

Mulige interessekonflikter

 

 

 

Nedenfor er en liste over mit samarbejde med private firmaer og interesseorganisationer

 

Title and sponsor

(private entities in bold)

Activity

Participants

(private entities in bold)

Period

A plant-produced immunoenhanced pig vaccine against PRRS PIGVAC. Danish Strategic Research Council

 

Research project

University of Århus (AU); SEGES Innovation; Boehringer Ingleheim AH, Germany; DTU; IVI, Switzerland;

2014- 2018

Viral diseases in mink. Danish Fur.

Research project

Danish Fur, DTU

2014-2015

Control of PRRSV in Denmark. SEGES

Research project

SEGES INNOVATION

2014-2015

Control of highly virulent/pathogenic European porcine reproductive and respiratory syndrome viruses – KilleuPRRS. ANIWHA

Research project

University of Gent, Belgium; IVI, Switzerland;  VLA, UK

2015-2018

Objective surveillance of swine diseases. Svineafgiftsfonden

Research project

SEGES INNOVATION, KU, DTU

2015- 2017

ADV – epidemiology and infection dynamics. Minkafgiftsfonden

Research project

DTU, Danish Fur

2016- 2017

Swine influenza – impact and control. IDT; CEVA and SEGES

Research project

DTU, IDT (Germany); SEGES INNOVATION

2016-2020

PCV2, PCV3 and PRRSV in Danish swine. SEGES and CEVA AH, France

Research project

DTU, SEGES INNOVATION, CEVA AH, France

2016-2017

Sekvensanalyse af patogener hos kvæg. SEGES

Research project

SEGES INNOVATION

2018

Influenza in mink – pathogenesis and control. Minkafgiftsfonden

Research project

Danish Fur

2018-2019

OUA project. GUDP

Research project

Danish Crown, SEGES INNOVATION, DTU, SSI

2017-2021

Robuste kalve. KAF

Research project

SEGES INNOVATION, AU, DTU

2018-2021

PRRSV control. Boehringer Ingleheim AH, Germany

Research project

Boehringer Ingleheim AH, Germany; DTU

2019

PPV sequencing and cross reactivity. Boehringer Ingleheim AH, Germany

Collaborative project

Boehringer Ingleheim AH, Germany; DTU

2019

PRRSV mass vaccination.

Svineafgiftsfondet

Research project

SEGES INNOVATION, DTU, MSD Animal Health

2019-2020

PRRSV award. Boehringer Ingleheim AH, Germany;

Research Award

Boehringer Ingleheim AH, Germany; DTU

2020

Zoonotic impact of swine influenza viruses. NNF

Research project

SSI, DTU, St. Jude hospital, Memphis, US

2020-2025

Invited participation in national and international meetings on viral infections sponsored by private entities

Presentations; scientific discussions

Boehringer Ingleheim AH, Germany; CEVA Animal Health, France; MSD AH, US; HIPRA, Spain; Zoetis AH, Spain

2015-

Meetings on viral infections in swine. SEGES

Presentations; scientific discussions; written assessments

SEGES

2015-

PRRSV expert panel member. Pig333 website (Hipra, Spain)

Answer of questions raised by veterinarians globally

Hipra, Spain

2016-

Aktuel forskning

Udvalgte aktuelle projekter:

FluZooMark - zoonotic aspects of swine influenza viruses - 2020-2025 - Novo Nordisk Foundation - 60 mill. DKK

PRRSV - sequencing, opathogeneses, vaccine strategies- 2020 - SEGES - 400.000 DKK

PRRSV - impact of mass vaccination - Svine levy foundation/European PRRSV award - 450.000 DKK

Svine influenza virus -  diversity, diagnostics,  control - 2020 - 490.000 DKK

Emneord

  • Det Sundhedsvidenskabelige Fakultet
  • Virologi
  • Zoonoser

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