Publikationer pr. år
Publikationer pr. år
Professor
Stigbøjlen 4
1870 Frederiksberg C
Publikationer pr. år
Lars Erik Larsen (født 1963) er professor i veterinær virologi og har arbejdet med virusinfektioner i produktionsdyr i de sidste 20 år. Han har været involveret i forskning i svinevira (diagnostiske værktøjer, molekylær epidemiologi, vaccinologi og basal patogenese) i de sidste 15 år. Lars har deltaget i adskillige nationale og europæiske projekter om enzootiske svinevirus med fokus på PRRSV, PCV-2 og svineinfluenzavirus. Han er leder af forskningsgruppen for enzootisk / zoonotisk virus ved UCPH og er videnskabeligt ansvarlig for det nationale overvågningsprogram for virus af aviær influenza og svin og er formand for det danske ekspertudvalg for aviær influenza og Newcastle Disease. Lars er også ansvarlig for undervisningen af veterinærstuderende i veterinær virologi og er vejleder for en række ph.d.-, kandidat- og bachelorstuderende. Lars er i øjeblikket bestyrelsesmedlem i Dansk Selskab for Virologi. Han har offentliggjort mere end 100 internationale peer review-artikler om veterinær virologi og har medforfatter til mere end 300 andre publikationer.
Gruppens forskningsmæssige kerneområde er influenzavirus i fugle og svin. Forskningen er fokuseret på udredningen af de faktorer, der afgør om et givet influenza-isolat kan smitte mennesker (zoonotiske aspekter), og hvilke virale determinanter, der er ansvarlig for, at virus kan forårsage alvorlig sygdom.
Gruppen var således de første til at demonstrere distributionen og sammensætningen af influenza A virus receptorer i svin. Gruppen deltager endvidere i EU og nationale projekter vedrørende andre vigtige virusinfektioner som PRRSV, Hepatitis E, diarre hos svin, virus hos kalve, fjerkræ, mink og vildt samt innovationsprojekter vedrørende udvikling anvendelse af vacciner til forebyggelse af sygdomme hos produktionsdyr
Forskningsaktiviteterne foregår både i cellekulturer og i dyremodeller. Et reverse genetic system til manipulation af influenzavirus er etableret, og gruppen anvender såvel konventionel som NGS (Next Generation Sequencing) til detaljerede analyser af virusevolution.
Forskningen inden for influenzavirus er essentiel for forskningsmæssigt at understøtte et forudseende veterinært beredskab og en opdateret diagnostisk portefølje i Dansk veterinær Konsortium samtidig med at resultaterne bidrager med vigtig ny viden, der kan anvendes direkte i vurderingen af den zoonotiske risiko af fremtidige nye influenzavirus.
Forskningen indenfor almindeligt forekommende (enzootisk) virusinfektioner foregår i tæt samarbejde med og delvist finansieret af organisationerne Landbrug & Fødevarer, SEGES samt Danish Fur og bidrager til at fastholde Danmarks konkurrenceevne inden for den animale produktion ligesom forskningen bidrager til forbedret dyrevelfærd, højere produktivitet, samt en bedre fødevaresikkerhed.
Personal information
Name: Lars Erik Larsen
Born: February 18, 1963 in Horsens; Denmark
Private: Home address: Parkvej 7a 3550 Slangerup
Private status Two kids (Simon from 1996 and Stefan from 1998)
Nationality: Danish
Current position: Professor
Work address: Department of Veterinary and Animal Sciences
Faculty of Health and Medical Sciences
University of Copenhagen
Dyrlægevej 88
1870 Frederiksberg C
Education (Academic Qualifications)
1991 D.V.M.; The Royal Veterinary and Agricultural University, Denmark
1998 Ph.D.; The Royal Veterinary and Agricultural University, Denmark
2008 Diplomate of European College of Porcine Health Management (Dipl. ESPHM)
Awards
2002 O. Jensen's Memorial Award for work on BRSV in calves
2008 European PCV2 Award; Boehringer Ingelheim, Germany
2019 European PRRSV Award; Boehringer Ingelheim, Germany
Employment
Jan 1991 - Aug 1991 Visiting Research Scientist, Iowa State University; USA
Aug 1991 - Oct 1993 Study director, Scantox A/S, Ll. Shendsved; Denmark
Oct 1993 - Oct 2004 Senior Scientist Nycomed Imaging, Oslo, Norway
Nov 1994 - Dec 1997 Ph.d. Scholarship: Department of Veterinary Microbiology, RVAU, DK
Dec 1997 - Dec 2000 Research Scientist, Danish Veterinary Laboratory, Copenhagen, Denmark
Jan 2001 - May 2003 Senior Research Scientist, Danish Veterinary Laboratory, Copenhagen, DK
May 2003 - Dec 2003 Senior Scientist, Department of Virology, Novonordisk A/S, Bagsværd, DK
Jan 2004 - Jan 2009 Head of Section, National Veterinary Institute, DK
Aug 2010 - 2019 Professor, National Veterinary Institute; DTU, DK
2019- present Professor, IVH, KU, DK
Teaching Experience and Censorships
2001- Member of evaluation committees at minimum 15 bachelor, master and PhD exams at KU-LIFE
2001- Co-advisor for 25 master students at DTU-VET and KU
2005- Member of PhD evaluation committees in Sweden; Spain, Norway and Belgium
2006- Main supervisor for 10 PhD students
2010- Study responsible and main teacher of ”Virology for Veterinary Students”
Publications
103 peer reviewed; more than 300 others. H index: 27 (5 years calculated by Scholar august 2018). Total citations 1041 (938 without self citations). 19 citations/paper on average (Scorpus 2018). Research areas: Viral pathogenesis; Molecular epidemiology; vaccine development and assessment; development of diagnostic methods. Wild birds, poultry, swine, cattle, mink.
Full list of publications: ORCID: 0000-0003-0730-5555.
Management experience/education
In 2004, I was appointed Head of Section of Pathology, Molecular Microbiology and Virology at the Division of Veterinary Diagnostic and Research. From 2004-2006, I was responsible for personnel management, budgets, work safety etc. of 27 employees including 6 senior scientists, 8 post docs/PhD students and 13 lab technicians. This position constituted 50% of my time, including participation in the management team of the division.
In 2007-2008, the pathology group constituting 9 employees was transferred to another section. From 2009, I was responsible for the virus research and diagnostic development group which constituted me, 3 post docs/scientists; 3 PhD students and 5 lab technicians. From August 2014, I have been responsible for the research group, which presently consist of one post doc, one molecular biologist, three PhD students and lab technicians.
In addition to my practical experience with (line) management, I have passed the exam of the first two courses of the certified Danish “Diploma in Management” education.
I have several years of experience as scientific project manager of small and large research projects with participation from several different institutions and countries. In addition, I have had the scientific responsibility for the virus group at DTU-VET since 1998. Finally, I have completed a formal education in project management provided by the former Ministry of Food and Agriculture.
Nedenfor er en liste over mit samarbejde med private firmaer og interesseorganisationer
Title and sponsor (private entities in bold) |
Activity |
Participants (private entities in bold) |
Period |
A plant-produced immunoenhanced pig vaccine against PRRS PIGVAC. Danish Strategic Research Council |
Research project |
University of Århus (AU); SEGES Innovation; Boehringer Ingleheim AH, Germany; DTU; IVI, Switzerland; |
2014- 2018 |
Viral diseases in mink. Danish Fur. |
Research project |
Danish Fur, DTU |
2014-2015 |
Control of PRRSV in Denmark. SEGES |
Research project |
SEGES INNOVATION |
2014-2015 |
Control of highly virulent/pathogenic European porcine reproductive and respiratory syndrome viruses – KilleuPRRS. ANIWHA |
Research project |
University of Gent, Belgium; IVI, Switzerland; VLA, UK |
2015-2018 |
Objective surveillance of swine diseases. Svineafgiftsfonden |
Research project |
SEGES INNOVATION, KU, DTU |
2015- 2017 |
ADV – epidemiology and infection dynamics. Minkafgiftsfonden |
Research project |
DTU, Danish Fur |
2016- 2017 |
Swine influenza – impact and control. IDT; CEVA and SEGES |
Research project |
DTU, IDT (Germany); SEGES INNOVATION |
2016-2020 |
PCV2, PCV3 and PRRSV in Danish swine. SEGES and CEVA AH, France |
Research project |
DTU, SEGES INNOVATION, CEVA AH, France |
2016-2017 |
Sekvensanalyse af patogener hos kvæg. SEGES |
Research project |
SEGES INNOVATION |
2018 |
Influenza in mink – pathogenesis and control. Minkafgiftsfonden |
Research project |
Danish Fur |
2018-2019 |
OUA project. GUDP |
Research project |
Danish Crown, SEGES INNOVATION, DTU, SSI |
2017-2021 |
Robuste kalve. KAF |
Research project |
SEGES INNOVATION, AU, DTU |
2018-2021 |
PRRSV control. Boehringer Ingleheim AH, Germany |
Research project |
Boehringer Ingleheim AH, Germany; DTU |
2019 |
PPV sequencing and cross reactivity. Boehringer Ingleheim AH, Germany |
Collaborative project |
Boehringer Ingleheim AH, Germany; DTU |
2019 |
PRRSV mass vaccination. Svineafgiftsfondet |
Research project |
SEGES INNOVATION, DTU, MSD Animal Health |
2019-2020 |
PRRSV award. Boehringer Ingleheim AH, Germany; |
Research Award |
Boehringer Ingleheim AH, Germany; DTU |
2020 |
Zoonotic impact of swine influenza viruses. NNF |
Research project |
SSI, DTU, St. Jude hospital, Memphis, US |
2020-2025 |
Invited participation in national and international meetings on viral infections sponsored by private entities |
Presentations; scientific discussions |
Boehringer Ingleheim AH, Germany; CEVA Animal Health, France; MSD AH, US; HIPRA, Spain; Zoetis AH, Spain |
2015- |
Meetings on viral infections in swine. SEGES |
Presentations; scientific discussions; written assessments |
SEGES |
2015- |
PRRSV expert panel member. Pig333 website (Hipra, Spain) |
Answer of questions raised by veterinarians globally |
Hipra, Spain |
2016- |
Udvalgte aktuelle projekter:
FluZooMark - zoonotic aspects of swine influenza viruses - 2020-2025 - Novo Nordisk Foundation - 60 mill. DKK
PRRSV - sequencing, opathogeneses, vaccine strategies- 2020 - SEGES - 400.000 DKK
PRRSV - impact of mass vaccination - Svine levy foundation/European PRRSV award - 450.000 DKK
Svine influenza virus - diversity, diagnostics, control - 2020 - 490.000 DKK
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Andet › Udgivelser på nettet - Net-publikation › Formidling
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Carsten Kirkeby (Redaktør), Lene Jung Kjær (Deltager), Anette Ella Boklund (Deltager), Yangfan Liu (Deltager), Lars Erik Larsen (Deltager), Yuan Liang (Deltager), Charlotte Kristiane Hjulsager (Deltager) & Helene Ane Jensen (Deltager)
Aktivitet: Andre aktivitetstyper › Andet
Lene Jung Kjær (Andet), Charlotte Hjulsager (Andet), Lars Erik Larsen (Andet), Anette Ella Boklund (Andet), Tariq Halasa (Andet), Michael P. Ward (Andet) & Carsten Kirkeby (Andet)
Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
Lene Jung Kjær (Andet), Carsten Kirkeby (Andet), Anette Ella Boklund (Andet), Lars Erik Larsen (Andet), Charlotte Kristiane Hjulsager (Andet), Tariq Halasa (Andet) & Michael P. Ward (Andet)
Aktivitet: Tale eller præsentation - typer › Foredrag og mundtlige bidrag
10/03/2020
1 element af Mediedækning, 1 Mediebidrag
Presse/medie