Kort præsentation

My name is Lasse Krog, and I’m a nanoscientist/biophysicist by training and a PhD student in the Structured Biointerfaces group at the Department of Pharmacy, University of Copenhagen, led by Professor Ben Boyd. In the group, we are interested in the interactions at the interface of particles with both endogenous and exogenous molecules in the gut, including lipids, and how these materials change over time. Lipids also self-assemble in water to form ordered structures with implications for their interactions with the gut environment. Low-frequency Raman (LFR) spectroscopy has in recent years gained momentum for the characterization of the solid-state properties of pharmaceuticals. Raman scattering is a phenomenon where incoming light interacts with the sample, changing the energy of the outcoming light, hence in-elastic scattering with changes in energy. The LFR regime holds information about structure, hence I am specifically interested in its potential for structural characterization of ordered soft matter. Our publication in ACS Physical Chemistry B reports the use of LFR to probe ordered lipid systems, in this case focussing on the kinetics of hydration of lipid systems. This is to our knowledge, the first time these mesophase systems have been probed by LFR spectroscopy and opens the laboratory to the in-situ characterization of ordered lipid systems, which has typically required the use of high-end facilities such as synchrotron X-ray scattering. If you are interested in the kinetics of lipid phase transformations, you should check out our publication. You can find our article here: https://doi.org/10.1021/acs.jpcb.2c08150