Lennart Bunch

Publikation

Publikationer pr. år 2001 2009 2011 2012 2013 2014 2015 2016 2017 2020 2022 2024

• 2316 Citationer
• 76 Tidsskriftartikel
• 4 Review
• 2 Bidrag til bog/antologi
• 2 Kommentar/debat
• 2 Mere
  • 1 Letter
  • 1 Patent

Publikationer pr. år

Publikationer pr. år

Søgeresultater

• 2024

  Design, Synthesis, Pharmacology, and In Silico Studies of (1S,2S,3S)-2-((S)-Amino(carboxy)methyl)-3-(carboxymethyl)cyclopropane-1-carboxylic Acid (LBG30300): A Picomolar Potency Subtype-Selective mGlu₂ Receptor Agonist

  Liu, N., Eshak, F., Malhaire, F., Brabet, I., Prézeau, L., Renard, E., Pin, J. P., Acher, F. C., Staudt, M. & Bunch, L., 2024, I: Journal of Medicinal Chemistry. 67, 2, s. 1314–1326

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  1 Citationer (Scopus)

• Domoic Acid as a Lead for the Discovery of the First Selective Ligand for Kainate Receptor Subtype 5 (GluK5)

  Buschbom-Helmke, S., Wang, P., Alcaide, A., Miguez-Cabello, F., Carta, M., Viotti, J. S., Nielsen, B., Mulle, C., Bowie, D., Jørgensen, F. S., Pickering, D. S. & Bunch, L., 2024, (Accepteret/In press) I: Journal of Medicinal Chemistry.

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• Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists

  Staudt, M., Liu, N., Malhaire, F., Doroudian, Y., Prézeau, L., Renard, E., Hasanpour, Z., Pin, J. P. & Bunch, L., 2024, I: European Journal of Medicinal Chemistry. 266, 11 s., 116157.

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  11 Downloads (Pure)
• 2023

  Convenient access to β-substituted cysteines and β- and γ-mercapto prolines

  Hansen, J. C., Rabuffetti, M. & Bunch, L., 2023, I: Canadian Journal of Chemistry. 101, 5, s. 326-333

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• In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

  Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, L., Clausen, R. P. & Wünsch, B., 2023, I: Biological Chemistry. 404, 4, s. 255-265

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  2 Citationer (Scopus)
• 2022

  (S)-2-Mercaptohistidine: A First Selective Orthosteric GluK3 Antagonist

  Poulie, C. B. M., Larsen, Y., Leteneur, C., Barthet, G., Bjorn-Yoshimoto, W. E., Malhaire, F., Nielsen, B., Pin, J. P., Mulle, C., Pickering, D. S. & Bunch, L., 2022, I: ACS Chemical Neuroscience. 13, 10, s. 1580–1587

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• Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

  Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, I: Journal of Medicinal Chemistry. 65, 1, s. 734-746

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  5 Citationer (Scopus)

• Discovery of (R)-2-amino-3-triazolpropanoic acid derivatives as NMDA receptor glycine site agonists with GluN2 subunit-specific activity

  Zhao, F., Mazis, G., Yi, F., Lotti, J. S., Layeux, M. S., Schultz, E. P., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, I: Frontiers in Chemistry. 10, 13 s., 1008233.

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  2 Citationer (Scopus)

  15 Downloads (Pure)

• Synthesis of phenol derivatives from cyclopentenones with arynes as key intermediates

  Telese, D., Staudt, M. & Bunch, L., 2022, I: Results in Chemistry. 4, 7 s., 100412.

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• Transition Metal-Free Synthesis of meta-Bromo- and meta-Trifluoromethylanilines from Cyclopentanones by a Cascade Reaction

  Staudt, M., Cetin, A. & Bunch, L., 2022, I: Chemistry: A European Journal. 28, 10, 5 s., 202102998.

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  19 Downloads (Pure)
• 2021

  Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential

  Hasanpour, Z., Salehi, P., Bunch, L., Khoramjouy, M., Bararjanian, M., Stærk, D. & Faizi, M., 2021, I: Canadian Journal of Chemistry. 99, 11, s. 910-919

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  2 Citationer (Scopus)

• Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring-Opening

  Staudt, M., Sølling, T. I. & Bunch, L., 2021, I: Chemistry - A European Journal. 27, 42, s. 10941–10947 7 s.

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• 2020

  A Diversity Oriented Synthesis Approach to New 2,3-trans-Substituted l-Proline Analogs as Potential Ligands for the Ionotropic Glutamate Receptors

  Kayser, S., Temperini, P., Poulie, C. B. M., Staudt, M., Nielsen, B., Pickering, D. S. & Bunch, L., 4 mar. 2020, I: ACS Chemical Neuroscience. 11, s. 702-714 13 s.

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  7 Citationer (Scopus)

• Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT_2A/mGlu₂ Receptor Complex

  Poulie, C. B. M., Liu, N., Jensen, A. A. & Bunch, L., 2020, I: Journal of Medicinal Chemistry. 63, 17, s. 9928-9949 22 s.

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  12 Citationer (Scopus)

• From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Receptors

  Wang, P-F., Jensen, A. A. & Bunch, L., 2020, I: ACS Chemical Neuroscience. 11, 24, s. 4362-4375

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  10 Citationer (Scopus)

• Stereoselective Synthesis of New (2S,3R)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp3)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors

  Kayser, S., Hansen, J. C., Staudt, M., Moroz, A., Larsen, Y., Temperini, P., Yi, F., Syrenne, J. T., Krogsgaard-Larsen, N., Iliadis, S., Nielsen, B., Hansen, K. B., Pickering, D. S. & Bunch, L., 2020, I: ACS Chemical Neuroscience. 11, s. 674-701 28 s.

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  8 Citationer (Scopus)

• β-Indolyloxy Functionalized Aspartate Analogs as Inhibitors of the Excitatory Amino Acid Transporters (EAATs)

  Liu, N., Jensen, A. A. & Bunch, L., 2020, I: ACS Medicinal Chemistry Letters. 11, 11, s. 2212-2220 9 s.

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  1 Citationer (Scopus)
• 2019

  Design and Synthesis of 2,3-trans-Proline Analogs as Ligands for the Ionotropic Glutamate Receptors and the Excitatory Amino Acid Transporters

  Poulie, C. B. M., Alcaide Lopez, A., Krell-Jørgensen, M. P., Larsen, Y., Astier, E., Bjørn-Yoshimoto, W. E., Yi, F., Syrenne, J. T., Storgaard, M., Nielsen, B., Frydenvang, K. A., Jensen, A. A., Hansen, K. B., Pickering, D. S. & Bunch, L., 19 jun. 2019, I: A C S Chemical Neuroscience. 10, 6, s. 2989-3007 19 s.

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  4 Citationer (Scopus)

• Identification and Structure-Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

  Wu, P., Bjørn-Yoshimoto, W. E., Staudt, M., Jensen, A. A. & Bunch, L., 2019, I: ACS Chemical Neuroscience. 10, s. 4414-4429

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  10 Citationer (Scopus)

• The Screening and Design of Allosteric Kinase Inhibitors

  Wu, P., Dinér, P. & Bunch, L., 2019, Kinase Drug Discovery: Modern Approaches. 1. udg. Royal Society of Chemistry, s. 34-60

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  2 Citationer (Scopus)
• 2018

  Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors

  Fu, H., Zhang, J., Tepper, P. G., Bunch, L., Jensen, A. A. & Poelarends, G. J., 13 sep. 2018, I: Journal of Medicinal Chemistry. 61, 17, s. 7741-7753

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  16 Citationer (Scopus)

  221 Downloads (Pure)

• Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors

  Olander, E. R., Madjroh, N., Bunch, L., Söderhielm, P. C. & Jensen, A. A., 2018, I: Biochemical Pharmacology. 150, s. 305-319

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  7 Citationer (Scopus)

• Functionalization of Oxazolo[4,5-b]pyrazines by Deprotometallation

  Bisballe, N., Hedidi, M., Demmer, C. S., Chevallier, F., Roisnel, T., Dorcet, V., Halauko, Y. S., Ivashkevich, O. A., Matulis, V. E., Bentabed-Ababsa, G., Bunch, L. & Mongin, F., 7 aug. 2018, I: European Journal of Organic Chemistry. 29, s. 3904-3913

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  5 Citationer (Scopus)
• 2017

  Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist

  Gynther, M., Proietti Silvestri, I., Hansen, J. C., Hansen, K. B., Malm, T., Ishchenko, Y., Larsen, Y., Han, L., Kayser, S., Auriola, S., Petsalo, A., Nielsen, B., Pickering, D. S. & Bunch, L., 14 dec. 2017, I: Journal of Medicinal Chemistry. 60, 23, s. 9885-9904 20 s.

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  28 Citationer (Scopus)

• Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, I: Journal of Medicinal Chemistry. 60, 1, s. 441-457 17 s.

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  6 Citationer (Scopus)

• Revisiting the Quinoxalinedione scaffold in the Construction of New Ligands for the Ionotropic Glutamate Receptors.

  Demmer, C. S., Rombach, D., Liu, N., Nielsen, B., Pickering, D. S. & Bunch, L., 1 dec. 2017, I: A C S Chemical Neuroscience. 8, 11, s. 2477-2495 19 s.

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  16 Citationer (Scopus)

• Tetrabutylammonium Fluoride (TBAF) as a Mild and Versatile Reagent for Cleaving Boroxazolidones to their Corresponding Free α-Amino Acids

  Poulie, C. B. M. & Bunch, L., mar. 2017, I: European Journal of Organic Chemistry. 11, s. 1475-1478

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  3 Citationer (Scopus)
• 2016

  Beta-Sulfonamido Functionalized Aspartate Analogs as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype-Selectivity Profiles Arising from Subtle Structural Differences

  Hansen, J. C., Bjørn-Yoshimoto, W. E., Bisballe, N., Nielsen, B., Jensen, A. A. & Bunch, L., 2016, I: Journal of Medicinal Chemistry. 59, s. 8771-8786 16 s.

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  10 Citationer (Scopus)

• Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)

  Haym, I., Huynh, T. H. V., Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, I: ChemMedChem. 11, 4, s. 403-419 17 s.

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  9 Citationer (Scopus)

• Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity-Relationship Study

  Hansen, S. W., Erichsen, M. N., Fu, B., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Hansen, J. C., Jensen, A. A. & Bunch, L., 2016, I: Journal of Medicinal Chemistry. 59, 19, s. 8757-8770 14 s.

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  11 Citationer (Scopus)

• New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III

  Huynh, T. H. V., Erichsen, M. N., Tora, A. S., Goudet, C., Sagot, E., Assaf, Z., Thomsen, C., Brodbeck, R., Stensbol, T. B., Bjorn-Yoshimoto, W. E., Nielsen, B., Pin, J-P., Gefflaut, T. & Bunch, L., 2016, I: Journal of Medicinal Chemistry. 59, 3, s. 914-924 11 s.

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  13 Citationer (Scopus)

• New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102

  Hansen, S. W., Erichsen, M. N., Huynh, T. H. V., Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Hansen, J., Storgaard, M., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, I: ChemMedChem. 11, 4, s. 382-402 21 s.

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  4 Citationer (Scopus)

• Synthesis and Pharmacological Characterization of the Selective GluK1 Radioligand (S)-2-Amino-3-(6-[3H]-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)propanoic acid ([3H]-NF608)

  Alcaide, A., Marconi, L., Marek, A., Haym, I., Nielsen, B., Møllerud, S., Jensen, M., Conti, P., Pickering, D. S. & Bunch, L., 2016, I: MedChemComm. 7, s. 2136-2144 9 s.

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  19 Citationer (Scopus)
• 2015

  A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude)

  Hammer, H., Bader, B. M., Ehnert, C., Bundgaard, C., Bunch, L., Hoestgaard-Jensen, K., Schroeder, O. H-U., Bastlund, J. F., Gramowski-Voß, A. & Jensen, A. A., 2015, I: Molecular Pharmacology. 88, 2, s. 401-420 20 s.

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  48 Citationer (Scopus)

• Benzoxazoles and oxazolopyridines in medicinal chemistry studies

  Demmer, C. S. & Bunch, L., 2015, I: European Journal of Medicinal Chemistry. 97, s. 778-785 8 s.

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  127 Citationer (Scopus)

• Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

  Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, D. S., Nielsen, B., Bowie, D., Frydenvang, K., Kastrup, J. S. & Bunch, L., 9 apr. 2015, I: A C S Chemical Neuroscience. 6, s. 845-854 10 s.

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  17 Citationer (Scopus)

• Blood-brain barrier permeability and brain uptake mechanism of kainic Acid and dihydrokainic Acid

  Gynther, M., Petsalo, A., Hansen, S. H., Bunch, L. & Pickering, D. S., mar. 2015, I: Neurochemical Research. 40, 3, s. 542-549 8 s.

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  17 Citationer (Scopus)

• Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities

  Jensen, A. A., Fahlke, C., Bjørn-Yoshimoto, W. E. & Bunch, L., 2015, I: Current Opinion in Pharmacology. 20, s. 116-123 8 s.

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  77 Citationer (Scopus)

• Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid

  Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., Monrad, R. N., Nielsen, B., Tapken, D., Pickering, D. S., Kastrup, J. S., Frydenvang, K. & Bunch, L., 2015, I: Journal of Medicinal Chemistry. 58, 15, s. 6131-50 20 s.

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  20 Citationer (Scopus)

• Synthesis and Selective Functionalization of [1,2,4]Triazolo[4,3-a]pyrazines

  Demmer, C. S., Jorgensen, M., Kehler, J., Bunch, L. & Rasmussen, L. K., 2015, I: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 26, 4, s. 519-524 6 s.

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  10 Citationer (Scopus)

• The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

  Cuesta, E. P., Christensen, S., Jensen, A. A., Jensen, N. F., Bunch, L., Rømer, M. U. K., Brünner, N., Stenvang, J. & Pedersen, S. H. F., 2015, I: B M C Cancer. 15, 1, 17 s., 411.

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  386 Downloads (Pure)
• 2014

  Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

  Venskutonyte, R., Larsen, A. P., Frydenvang, K. A., Gajhede, M., Gefflaut, T., Pickering, D. S., Bunch, L. & Kastrup, J. S. J., 2014, I: ChemMedChem. 9, 10, s. 2254-2259 6 s.

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  7 Citationer (Scopus)

• New Palladium-Catalyzed Domino Reaction with Intramolecular Ring Closure of an N-(2-Chloro-3-heteroaryl) arylamide: First Synthesis of Oxazolo[4,5-b] pyrazines

  Demmer, C. S., Hansen, J. C., Kehler, J. & Bunch, L., 24 mar. 2014, I: Advanced Synthesis & Catalysis. 356, 5, s. 1047-1055 9 s.

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  9 Citationer (Scopus)

• Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: Design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

  Erichsen, M. N., Hansen, J., Artacho Ruiz, J., Demmer, C. S., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Jensen, A. A. & Bunch, L., 2014, I: Neurochemical Research. 39, 10, s. 1964-1979 16 s.

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  6 Citationer (Scopus)

• Profiling substrate specificity of two series of phenethylamine analogs at monoamine oxidase A and B

  Heuson, E., Storgaard, M., Huynh, T. H. V., Charmantray, F., Gefflaut, T. & Bunch, L., 2014, I: Organic & Biomolecular Chemistry. 12, 43, s. 8689-8695 7 s.

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  7 Citationer (Scopus)

• Study of Oxidative Cyclization Using PhI(OAc)(2) in the Formation of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazoles and Related Heterocycles - Scope and Limitations

  Demmer, C. S., Jorgensen, M., Kehler, J. & Bunch, L., jun. 2014, I: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis. 25, 9, s. 1279-1282 4 s.

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  9 Citationer (Scopus)

• Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

  Pinto, A., Tamborini, L., Mastronardi, F., Ettari, R., Safoz, Y., Bunch, L., Nielsen, B., Jensen, A. A., De Micheli, C. & Conti, P., 2014, I: European Journal of Medicinal Chemistry. 75, s. 151-158 8 s.

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  4 Citationer (Scopus)
• 2013

  Allosteric modulation of an excitatory amino acid transporter: The subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain

  Abrahamsen, B., Schneider, N., Erichsen, M. N., Huynh, T. H. V., Fahlke, C., Bunch, L. & Jensen, A. A., 2013, I: Journal of Neuroscience. 33, 3, s. 1068-1087

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  53 Citationer (Scopus)

• Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

  Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, B., Gajhede, M., Kastrup, J. S., Jensen, A. A., Pickering, D. S., Frydenvang, K., Gefflaut, T. & Bunch, L., 2013, I: Journal of Medicinal Chemistry. 56, 4, s. 1614-1628

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  38 Citationer (Scopus)

• Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

  Venskutonyte, R., Frydenvang, K., Gajhede, M., Bunch, L., Pickering, D. S. & Kastrup, J. S., nov. 2013, I: Journal of Structural Biology. 184, 2, s. 381 1 s.

  Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
  1 Citationer (Scopus)