Kort præsentation

G protein-coupled receptors (GPCRs) relay signals from the outside to the inside of the cell by coupling to G proteins and other intracellular mediators. GPCRs are the targets of around 30% of approved drugs and development of new and therapies is a major focus of academic groups and companies worldwide. In the Gustavsson group, we aim to understand the molecular details of receptor function and regulation and translate our findings to receptor physiology.

We combine characterization of receptor pharmacology in cells and reconstituted systems with characterization of receptor structure and dynamics. Our key methods are:

• Protein expression and purification in prokaryotic and eukaryotic systems
• Functional characterization by binding and signaling assays (BRET, FRET, radioligand binding, SPR etc)
• Receptor structure and dynamics (cryo-EM, NMR, FRET etc.)

Read more about the Gustavsson Group by clicking here

Primære forskningsområder

• Structural biology
• Receptor pharmacology and signaling
• G protein-coupled receptors
• Chemokine receptors

CV

• 2022- : Associate Professor. Department of Biomedical Sciences, University of Copenhagen.
• 2019-2022: Tenure-track Assistant Professor. Department of Biomedical Sciences, University of Copenhagen
• 2013-2019: Postdoctoral scholar. Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California San Diego, La Jolla, USA. Supervisor: Professor Tracy Handel
• 2007-2012: PhD in Biochemistry, Molecular Biology and Biophysics. University of Minnesota, Minneapolis, USA. Supervisor: Professor Gianluigi Veglia              
• 2002-2007: Master of Science in Chemical Biology. Linköping University, Linköping, Sweden

Funding

• 2019: Carlsberg Foundation Research Infrastructure. Project title: “Uncovering the structural basis for RAMP regulation of G protein-coupled receptors”
• 2019-2024: VILLUM Young Investigator Grant. Project title: “Allosteric control of G protein-coupled receptors”
• 2014-2016: Robertson Foundation/Cancer Research Institute. Irvington Postdoctoral Fellowship. Project title: “Structural basis of CXCR7/ACKR3 ligand binding and signaling”
• 2010-2012: Predoctoral Fellowship, American Heart Association. Project title: “Engineering a pH-Dependent Activity Switch in Phospholamban to Relieve Ca2+-ATPase Inhibition”