Billede af Meike Burow
  • Thorvaldsensvej 40, 1871 Frederiksberg C

  • Thorvaldsensvej 40

    1871 Frederiksberg C

  • Kilde: Scopus
20022024

Publikationer pr. år

Personlig profil

Kort præsentation

Head of Section for Molecular Plant Biology

 

Research focus: Metabolic and Regulatory Networks

Plant metabolism relies on interconnected regulatory feedback loops and balanced investments of resources into growth and defense. Different taxa, species and even chemotypes within a species have evolved different biosynthetic pathways leading to structurally highly diverse specialized metabolites. These pathways require different precursors as metabolic input, and typically specific cell types and microenvironments for production and storage of the compounds. Yet, as the functions of specialized metabolites generally depend on their accumulation in the right tissue at the right time, their biosynthetic pathways must share tight coordination with primary metabolism and development as a common feature.

To ultimately understand how plants integrate internal and external signals to orchestrate metabolic and developmental processes, we study transcriptional regulation (transcription factors, DNA methylation, chromatin modification), post-transcriptional regulation (regulatory RNAs, RNA stability), and post-translational regulation (protein modification, protein stability, protein-protein interactions, metabolite sensing) and how all these regulatory levels are coordinated on the molecular level.

Arabidopsis thaliana and its primary defense compounds, the glucosinolates, have been identified as a prime model system to study regulatory networks. Particularly, the chemically diverse methionine-derived glucosinolates have been recognized for their complex and dynamic regulatory network. Three closely related R2R3 MYB transcription factors have been characterized as direct regulators that cooperatively interact to shape the profile of methionine-derived glucosinolates which changes dynamically in time and space. Additional regulatory mechanisms which appear to contribute to controlling glucosinolate levels in the plant include metabolite sensing, RNA-mediated regulation and protein-protein interactions between biosynthetic enzymes to facilitate efficient channeling of pathway intermediates.

 

 

CV

Research Experience

Since 2020        

Professor, Department of Plant and Environmental Sciences, UCPH, Denmark

2011 - 2020            

Associate Professor, Department for Plant and Environmental Sciences, UCPH, Denmark

2008 – 2011             

Postdoc / Assistant Professor, Department for Plant Biology and Biotechnology, UCPH, Denmark

2006 – 2007             

Post-doctoral researcher, Institut für Pharmazeutische Biologie, TU Braunschweig, Germany

2001 – 2006             

PhD student, Max Planck Insitute for Chemical Ecology, Jena, Germany

 

Educational Record      

Dipl. Biol. (with excellence), University of Hannover, Germany, Sep. 2001

Dr. rer. nat. (summa cum laude), Friedrich Schiller Universität, Jena, Germany, March 2008 

 

Teaching

Head of studies for the BSc program in Biotechnology

Introduktion til bioteknologi (BSc level)

Experimental Molecular Biology / Project in Experimental Molecular Biology (BSc level, course coordinator)

Big Data in Biotechnology (MSc level)

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