Melanie Blasius

Fastnet+4535334455
E-mailblasiussund.kudk
Webstedhttps://icmm.ku.dk/

Blegdamsvej 3
2200 København N.

Publikationer pr. år

Kort præsentation

The overarching aim for the group (Bekker-Jensen Group) is to understand the molecular details of cellular stress responses and how they contribute to human diseases such as cancer and aging-related maladies. We are especially interested in understanding the mechanisms by which the MAP kinases p38 and JNK become activated in response to cellular stress insults such as ribosomal impairment, oxidative stress and high osmolarity, and how such signaling drives or protect against pathological cellular changes. Importantly, the same signaling pathways are crucial for inflammatory responses, adding to the relevance of our work for a range of human diseases.

268 Citationer
9 Tidsskriftartikel
1 Review

Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Johansen, V. B. I., Snieckute, G., Vind, A. C., Blasius, M. & Bekker-Jensen, S., 2023, I: Cells. 12, 6, 969.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Fil

2 Citationer (Scopus)

32 Downloads (Pure)
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Ryder, L., Arendrup, F. S., Martínez, J. F., Snieckute, G., Pecorari, C., Shah, R. A., Lund, A. H., Blasius, M. & Bekker-Jensen, S., 2023, I: Cell Death & Disease. 14, 7, 10 s., 467.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Fil

5 Citationer (Scopus)

21 Downloads (Pure)
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 flere, Lund, A. H., Treebak, J. T., Olsen, J. V., Poulsen, S. S., Pownall, M. E., Jensen, B. A. H., Clemmensen, C., Gerhart-Hines, Z., Gatfield, D. & Bekker-Jensen, S., 2023, I: Science (New York, N.Y.). 382, 6675, 14 s., eadf3208.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Fil

21 Citationer (Scopus)

52 Downloads (Pure)
Run, Ribosome, Run: From Compromised Translation to Human Health
Vind, A. C., Snieckute, G., Bekker-Jensen, S. & Blasius, M., 2023, I: Antioxidants & Redox Signaling. 39, 4-6, s. 336-350 15 s.
Publikation: Bidrag til tidsskrift › Review › Forskning › peer review

Åben adgang
Fil

5 Citationer (Scopus)

7 Downloads (Pure)
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Snieckute, G., Genzor, A. V., Vind, A. C., Ryder, L., Stoneley, M., Chamois, S., Dreos, R., Nordgaard, C., Sass, F., Blasius, M., López, A. R., Brynjólfsdóttir, S. H., Andersen, K. L., Willis, A. E., Frankel, L. B., Poulsen, S. S., Gatfield, D., Gerhart-Hines, Z., Clemmensen, C. & Bekker-Jensen, S., 2022, I: Cell Metabolism. 34, 12, s. 2036-2046.e8 20 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Fil

28 Citationer (Scopus)

47 Downloads (Pure)
ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
Nordgaard, C., Vind, A. C., Stonadge, A., Kjøbsted, R., Snieckute, G., Antas, P., Blasius, M., Reinert, M. S., Del Val, A. M., Bekker-Jensen, D. B., Haahr, P., Miroshnikova, Y. A., Mazouzi, A., Falk, S., Perrier-Groult, E., Tiedje, C., Li, X., Jakobsen, J. R., Jørgensen, N. O., Wojtaszewski, J. & 12 flere, Mallein-Gerin, F., Andersen, J. L., Pennisi, C. P., Clemmensen, C., Kassem, M., Jafari, A., Brummelkamp, T., Li, V. S., Wickström, S. A., Olsen, J. V., Blanco, G. & Bekker-Jensen, S., 2022, I: E M B O Journal. 41, 17, 19 s., e111650.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Fil

16 Citationer (Scopus)

69 Downloads (Pure)
Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses
Nordgaard, C., Tollenaere, M. A. X., Del Val, A. M., Bekker-Jensen, D. B., Blasius, M., Olsen, J. V. & Bekker-Jensen, S., 2021, I: International Journal of Molecular Sciences. 22, 17, 23 s., 9595.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Åben adgang
Fil

8 Citationer (Scopus)

37 Downloads (Pure)
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
Vind, A. C., Snieckute, G., Blasius, M., Tiedje, C., Krogh, N., Bekker-Jensen, D. B., Andersen, K. L., Nordgaard, C., Tollenaere, M. A. X., Lund, A. H., Olsen, J. V., Nielsen, H. & Bekker-Jensen, S., 2020, I: Molecular Cell. 78, 4, s. 700-713.E7
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

83 Citationer (Scopus)

Melanie Blasius

Personlig profil

Kort præsentation

Samarbejde og topforskningsområder i de sidste fem år

Dyk ned i detaljerne

Computational and Functional Analysis of Structural Features in the ZAKα Kinase

Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms

ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

Run, Ribosome, Run: From Compromised Translation to Human Health

Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle

Regulation of the golgi apparatus by p38 and JNK kinases during cellular stress responses

ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains