Michal Tomasz Marzec

Søgeresultater

• 2024

  NOS2 Polymorphism in Aspect of Left and Right-Sided Colorectal Cancer

  Klusek, J., Lewitowicz, P., Oblap, R., Orlewska, E., Witczak, B., Marzec, M. T., Kozłowska-Geller, M., Nawacki, Ł., Wawszczak-Kasza, M., Kocańda, K., Jóźwik, A. & Głuszek, S., 2024, I: Journal of Clinical Medicine. 13, 4, 11 s., 937.

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  1 Citationer (Scopus)

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• 2023

  FK506-Binding Protein 2 Participates in Proinsulin Folding

  Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 flere, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, T. & Marzec, M. T., 2023, I: Biomolecules. 13, 1, 20 s., 152.

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  3 Citationer (Scopus)

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• Glutathione S-Transferase P1 Genetic Variant’s Influence on the HbA1c Level in Type Two Diabetic Patients

  Orlewska, K., Klusek, J., Głuszek, S., Klusek, J., Witczak, B., Wawszczak, M., Madej, Ł., Marzec, M. T. & Orlewska, E., 2023, I: International Journal of Environmental Research and Public Health. 20, 2, 9 s., 1520.

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  2 Citationer (Scopus)

  127 Downloads (Pure)

• IDF2022-0254 Glutathione S-transferase P1 genetic variants influence the HbA1c level in diabetic patients

  Klusek, J., Głuszek, S., Orlewska, K., Marzec, M. T., Wawszczak-kasza, M., Madej, Ł., Klusek, J., Witczak, B. & Orlewska, E., 2023, I: Diabetes Research and Clinical Practice. 197, Suppl. 1, 1 s., 110268.

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• Immunometabolism in type 2 diabetes mellitus: tissue-specific interactions

  Pinheiro-Machado, E., Convey, E. G. & Marzec, M. T., 2023, I: Archives of Medical Science. 19, 4, 17 s.

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  8 Citationer (Scopus)

  12 Downloads (Pure)
• 2022

  Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells

  Khilji, M. S., Faridi, P., Pinheiro-Machado, E., Hoefner, C., Dahlby, T., Aranha, R., Buus, S., Nielsen, M., Klusek, J., Mandrup-Poulsen, T., Pandey, K., Purcell, A. W. & Marzec, M. T., 2022, I: Biomedicines. 10, 4, 814.

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  3 Citationer (Scopus)

  38 Downloads (Pure)
• 2021

  MCPIP1 is a novel link between diabetogenic conditions and impaired insulin secretory capacity

  Tyka, K., Joerns, A., Dunst, A., Tang, Y., Bryde, T. H., Mehmeti, I., Walentinsson, A., Marselli, L., Cnop, M., Tyrberg, B., Marzec, M. T. & Gurgul-Convey, E., 2021, I: B B A - Molecular Basis of Disease. 1867, 10, 12 s., 166199.

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  4 Citationer (Scopus)

• Peanut-shaped gold nanoparticles with shells of ceragenin csa-131 display the ability to inhibit ovarian cancer growth in vitro and in a tumor xenograft model

  Piktel, E., Oscilowska, I., Suprewicz, Ł., Depciuch, J., Marcińczyk, N., Chabielska, E., Wolak, P., Głuszek, K., Klimek, J., Zieliński, P. M., Marzec, M. T., Savage, P. B., Parlińska-Wojtan, M. & Bucki, R., 2021, I: Cancers. 13, 21, s. 1-26 5424.

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  11 Citationer (Scopus)

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• 2020

  Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in beta-Cells

  Dahlby, T., Simon, C., Backe, M. B., Dahllof, M. S., Holson, E., Wagner, B. K., Boni-Schnetzler, M., Marzec, M. T., Lundh, M. & Mandrup-Poulsen, T., 2020, I: International Journal of Molecular Sciences. 21, 21, 18 s., 8016.

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  6 Citationer (Scopus)

  32 Downloads (Pure)

• Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production

  Argon, Y., Bresson, S. E., Marzec, M. T. & Grimberg, A., 2020, I: Cells. 9, 8, 12 s., 1844.

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  15 Citationer (Scopus)

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• In silico approach to predict pancreatic β-cells classically secreted proteins

  Pinheiro-Machado, E., Sandberg, T. O. M., Pihl, C., Hägglund, P. M. & Marzec, M. T., 1 jan. 2020, I: Bioscience Reports. 40, 2, 13 s., BSR20193708.

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  1 Citationer (Scopus)

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• The inducible beta 5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets

  Khilji, M. S., Bresson, S. E., Verstappen, D., Pihl, C., Andersen, P. A. K., Agergaard, J. B., Dahlby, T., Bryde, T. H., Klindt, K., Nielsen, C. K., Walentinsson, A., Zivkovic, D., Bousquet, M-P., Tyrberg, B., Richardson, S. J., Morgan, N. G., Mandrup-Poulsen, T. & Marzec, M. T., 2020, I: American Journal of Physiology: Endocrinology and Metabolism. 318, 6, s. E892-E900

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  8 Citationer (Scopus)

• The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β

  Khilji, M. S., Verstappen, D., Dahlby, T., Prause, M. C. B., Pihl, C., Bresson, S. E., Bryde, T. H., Andersen, P. A. K., Klindt, K., Zivkovic, D., Bousquet-Dubouch, M. P., Tyrberg, B., Mandrup-Poulsen, T. & Marzec, M. T., 2020, I: PLoS ONE. 15, 2, 21 s., e0222432.

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  13 Citationer (Scopus)

  103 Downloads (Pure)
• 2019

  Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

  Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, C., Bresson, S. E., Khilji, M. S., Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, T. & Marzec, M. T., apr. 2019, I: Diabetes. 68, 4, s. 747-760 14 s.

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  48 Citationer (Scopus)

• MCPIP1 regulates insulin biosynthesis and glucose-stimulated insulin secretion: [Meeting Abstract]

  Tyka, K., Brydde, T. H., Wilamowski, M., Jura, J., Marzec, T. & Gurgul-Convey, E., 2019, I: FEBS Open Bio. 9, S1, s. 87-87 P-01-064.

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• 2018

  Students’ supervision and introduction during the initial period in the research laboratory: does it matter?

  Marzec, M. T., 2018, Improving University Science Teaching and Learning: Pedagogical Projects 2018. Department of Science Education, University of Copenhagen, Denmark, s. 107-114 8 s. (Improving University Science Teaching and Learning - Pedagogical Projects, Bind 12).

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• 2017

  Unexpected profile of sphingolipid contents in blood and bone marrow plasma collected from patients diagnosed with acute myeloid leukemia

  WAtek, M., Wollny, T., Pasiarski, M., Gozdz, S., Durnas, B., Wolak, P., Bucki, R., Marzec, M., Chabowska, A. & Zendzian-Piotrowska, M., 2017, I: Lipids in Health and Disease. 16, 1

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  23 Citationer (Scopus)
• 2016

  A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

  Marzec, M., Hawkes, C. P., Eletto, D., Boyle, S., Rosenfeld, R. G., Hwa, V., Wit, J. M., van Duyvenvoorde, H. A., Oostdijk, W., Losekoot, M., Pedersen, O., Yeap, B. B., Flicker, L., Barzilai, N., Atzmon, G., Grimberg, A. & Argon, Y., maj 2016, I: Endocrinology. 157, 5, s. 1914-1928 15 s.

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  11 Citationer (Scopus)

• Utility of blood procalcitonin concentration in the management of cancer patients with infections

  Durnas, B., Watek, M., Wollny, T., Niemirowicz, K., Marzec, M., Bucki, R. & Gozdz, S., 2016, I: OncoTargets and Therapy. 9, s. 469-475

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  36 Citationer (Scopus)
• 2014

  Variation in GRP94 Activity Impacts Production of Igfs and Human Growth

  Argon, Y., Grimberg, A., Rosenfeld, R. G. & Marzec, M., 2014, I: Endocrine Reviews. 35, 3

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• 2013

  Decreased lactate concentration and glycolytic enzyme expression reflect inhibition of mTOR signal transduction pathway in B-cell lymphoma.

  Lee, S-C., Marzec, M., Liu, X., Wehrli, S., Kantekure, K., Ragunath, P. N., Nelson, D. S., Delikatny, E. J., Glickson, J. D. & Wasik, M. A., 2013, I: NMR in Biomedicine. 26, 1, s. 106-114 9 s.

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  28 Citationer (Scopus)

• Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming

  Marzec, M., Halasa, K., Liu, X., Wang, H. Y., Cheng, M., Baldwin, D., Tobias, J. W., Schuster, S. J., Andersen, A. W., Zhang, Q., Turner, S. D., Ødum, N. & Wasik, M. A., 15 dec. 2013, I: Journal of immunology (Baltimore, Md. : 1950). 191, 12, s. 6200-7 8 s.

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  21 Citationer (Scopus)
• 2012

  GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

  Marzec, M., Eletto, D. & Argon, Y., mar. 2012, I: B B A - Reviews on Cancer. 1823, 3, s. 774-87 14 s.

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  324 Citationer (Scopus)

• Prediction and Early Detection of Response by NMR Spectroscopy and Imaging

  Lee, S-C., Arias-Mendoza, F., Poptani, H., Delikatny, E. J., Wasik, M., Marzec, M., Schuster, S. J., Nasta, S. D., Svoboda, J., O'Connor, O. A., Smith, M. R. & Glickson, J. D., jan. 2012, I: PET Clinics. 7, 1, s. 119-26 8 s.

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  1 Citationer (Scopus)
• 2011

  Oncogenic kinase NPM/ALK induces expression of HIF1 alpha mRNA

  Marzec, M. T., Liu, X., Wong, W., Yang, Y., Pasha, T., Kantekure, K., Zhang, P., Andersen, A. W., Cheng, M., Ødum, N. & Wasik, M. A., 2011, I: Oncogene. 30, 11, s. 1372-1378 7 s.

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  33 Citationer (Scopus)

• Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells

  Marzec, M. T., Liu, X., Wysocka, M., Rook, A. H., Ødum, N. & Wasik, M. A., 16 sep. 2011, I: PLoS ONE. 6, 9, 8 s., e24849.

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  49 Citationer (Scopus)

  157 Downloads (Pure)
• 2010

  Plasma gelsolin modulates cellular response to sphingosine 1-phosphate

  Bucki, R., Kulakowska, A., Byfield, F. J., Zendzian-Piotrowska, M., Baranowski, M., Marzec, M., Winer, J. P., Ciccarelli, N. J., Gorski, J., Drozdowski, W., Bittman, R. & Janmey, P. A., 2010, I: American Journal of Physiology: Cell Physiology. 299, 6, s. C1516-23

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  50 Citationer (Scopus)
• 2009

  Activation of mTORC1 signaling pathway in AIDS-related lymphomas.

  El-Salem, M., Raghunath, P. N., Marzec, M., Liu, X., Kasprzycka, M., Robertson, E. & Wasik, M. A., 2009, I: American Journal of Pathology. 175, 2, s. 817-824 8 s.

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  15 Citationer (Scopus)

• Anaplastic lymphoma kinase (ALK)-induced malignancies: novel mechanisms of cell transformation and potential therapeutic approaches

  Wasik, M. A., Zhang, Q., Marzec, M., Kasprzycka, M., Wang, H. Y. & Liu, X., 2009, I: Seminars in Oncology. 36, 2 Suppl 1, s. S27-35

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  38 Citationer (Scopus)
• 2008

  Differential Effects of Interleukin-2 and Interleukin-15 versus Interleukin-21 on CD4+ Cutaneous T-Cell Lymphoma Cells

  Marzec, M., Halasa, K., Kasprzycka, M., Wysocka, M., Liu, X., Tobias, J. W., Baldwin, D., Zhang, Q., Ødum, N., Rook, A. H. & Wasik, M. A., 2008, I: Cancer Research. 68, 4, s. 1083-91 8 s.

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  73 Citationer (Scopus)

• Expression of FOXP3(+) regulatory T-cell phenotype in neoplastic and reactive cells in early mycosis fungoides

  Witkiewicz, A. K., Potoczek, M., Kasprzycka, M., Marzec, M. & Wasik, MA., jan. 2008, I: Modern Pathology. 21, s. 103A-103A

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• gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4(+) T lymphocytes

  Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., 15 aug. 2008, I: Journal of Immunology. 181, 4, s. 2506-2512

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• IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes

  Marzec, M., Liu, X., Kasprzycka, M., Witkiewicz, A., Raghunath, P. N., El-Salem, M., Robertson, E., Ødum, N. & Wasik, M. A., 2008, I: Blood. 111, 4, s. 2181-9 8 s.

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  58 Citationer (Scopus)

• Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

  Marzec, M., Zhang, Q., Goradia, A., Raghunath, P. N., Liu, X., Paessler, M., Wang, H. Y., Wysocka, M., Cheng, M., Ruggeri, B. A. & Wasik, M. A., 30 dec. 2008, I: Proceedings of the National Academy of Sciences of the United States of America. 105, 52, s. 20852-7 6 s.

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  624 Citationer (Scopus)

• γc-Signaling Cytokines Induce a Regulatory T Cell Phenotype in Malignant CD4+ T Lymphocytes.

  Kasprzycka, M., Zhang, Q., Witkiewicz, A., Marzec, M., Potoczek, M., Liu, X., Wang, H. Y., Milone, M., Basu, S., Mauger, J., Choi, J. K., Abrams, J. T., Hou, J. S., Rook, A. H., Vonderheid, E., Woetmann, A., Odum, N. & Wasik, M. A., 2008, I: Journal of Immunology. 181, 4, s. 2506-2512 7 s.

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• 2007

  Constitutive activation of mTOR signaling pathway in post-transplant lymphoproliferative disorders.

  El-Salem, M., Raghunath, P. N., Marzec, M., Wlodarski, P., Tsai, D., Hsi, E. & Wasik, M. A., 2007, I: Laboratory Investigation. 87, 1, s. 29-39 11 s.

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  43 Citationer (Scopus)

• Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf.

  Marzec, M., Kasprzycka, M., Liu, X., Raghunath, P. N., Wlodarski, P. & Wasik, M. A., 2007, I: Oncogene. 26, 6, s. 813-821 9 s.

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  74 Citationer (Scopus)

• Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

  Marzec, M., Kasprzycka, M., Liu, X., El-Salem, M., Halasa, K., Raghunath, P. N., Bucki, R., Wlodarski, P. & Wasik, M. A., 2007, I: Oncogene. 26, 38, s. 5606-5614 9 s.

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  88 Citationer (Scopus)

• PU.1 activates transcription of SHP-1 gene in hematopoietic cells.

  Wlodarski, P., Zhang, Q., Liu, X., Kasprzycka, M., Marzec, M. & Wasik, M. A., 2007, I: Journal of Biological Chemistry. 282, 9, s. 6316-6323 8 s.

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  27 Citationer (Scopus)
• 2006

  Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.

  Kasprzycka, M., Majewski, M., Wang, Z-J., Ptasznik, A., Wysocka, M., Zhang, Q., Marzec, M., Gimotty, P., Crompton, M. R. & Wasik, M. A., 2006, I: American Journal of Pathology. 168, 5, s. 1631-1641 11 s.

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  34 Citationer (Scopus)

• Jak3 contributes to the activation of ALK and Stat3 in ALK + anaplastic large cell lymphoma. Response.

  Wasik, M. A. & Marzec, M., 2006, I: Laboratory Investigation. 86, 4, s. 420-421 2 s.

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• Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity

  Marzec, M., Kasprzycka, M., Lai, R., Gladden, A. B., Wlodarski, P., Tomczak, E., Nowell, P., DePrimo, S. E., Sadis, S., Eck, S., Schuster, S. J., Diehl, J. A. & Wasik, M. A., 1 sep. 2006, I: Blood. 108, 5, s. 1744-1750

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  134 Citationer (Scopus)

• Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing

  Nagasawa, T., Zhang, Q., Raghunath, P. N., Wong, H. Y., El-Salem, M., Szallasi, A., Marzec, M., Gimotty, P., Rook, A. H., Vonderheid, E. C., Odum, N. & Wasik, M. A., 2006, I: Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis. 30, 3, s. 303-12 9 s.

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  28 Citationer (Scopus)

• Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

  Kasprzycka, M., Marzec, M., Liu, X., Zhang, Q. & Wasik, M. A., 27 jun. 2006, I: Proceedings of the National Academy of Sciences of the United States of America. 103, 26, s. 9964-9969

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  140 Citationer (Scopus)

• Peroxisome Proliferator-Activated Receptor γ Promotes Lymphocyte Survival through Its Actions on Cellular Metabolic Activities.

  Jo, S-H., Yang, C., Miao, Q., Marzec, M., Wasik, M. A., Lu, P. & Wang, Y. L., 2006, I: Journal of Immunology. 177, 6, s. 3737-3745 9 s.

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  35 Citationer (Scopus)
• 2005

  Activation of Mammalian Target of Rapamycin in Transformed B Lymphocytes Is Nutrient Dependent but Independent of Akt, Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase, Insulin Growth Factor-I, and Serum.

  Wlodarski, P., Kasprzycka, M., Liu, X., Marzec, M., Robertson, E. S., Slupianek, A. & Wasik, M. A., 2005, I: Cancer Research. 65, 17, s. 7800-7808 9 s.

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  74 Citationer (Scopus)

• Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3

  Marzec, M., Kasprzycka, M., Ptasznik, A., Wlodarski, P., Zhang, Q., Ødum, N. & Wasik, M. A., 2005, I: Laboratory Investigation. 85, 12, s. 1544-54 10 s.

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  62 Citationer (Scopus)

• STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.

  Zhang, Q., Wang, H. Y., Marzec, M., Raghunath, P. N., Nagasawa, T. & Wasik, M. A., 2005, I: Proceedings of the National Academy of Sciences of the United States of America. 102, 19, s. 6948-6953 6 s.

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  224 Citationer (Scopus)