Billede af Peter Waaben Thulstrup

Peter Waaben Thulstrup

Cand. scient., Ph.D.

  • Universitetsparken 5, 772-02-2-C208

    2100 København Ø

    Danmark

  • Universitetsparken 5, 2100 København Ø, 73 Højhus 73, 73-5-T557

  • Universitetsparken 5

    2100 København Ø

  • Kilde: Scopus
19992024

Publikationer pr. år

Personlig profil

Kort præsentation

Protein and nucleic acid structures and development of their synthetic modification as tools to investigate aspects of biological chemistry

 

Scientific interests and techniques:

Bioinorganic, inorganic and physical chemistry; in particular:

  • Understanding the chemistry, function, and structural dynamics of biological macromolecules with particular regard to the role of metal ions
  • Metal ion uptake and regulation in biological systems
  • Peptide and protein (mis-)folding and self-assembly
  • Ordered systems and chirality
  • Circular and linear dichroism spectroscopy
  • Absorbance, fluorescence, and NMR spectroscopy including X nuclei
  • Small molecule dynamics and photophysics and applied computational chemistry

 

Main scientific equipment:

 Jasco J-815 spectropolarimeter with capabilities for CD, fluorescence, MCD (1.5 T), stopped-flow kinetics, automated titration, and flow linear dichroism spectroscopy.

  • Jasco FP-6300 Spectrofluorometer, Shimadzu UV-2401PC UV-VIS and Shimadzu UV-3600 UV-VIS-NIR, liquid nitrogen cryostats and an extensive collection of optical cells for various purposes.
  • Nicolet FT-IR for solid, liquid and gas analysis and other instruments for vibrational spectroscopy.
  • Joint facilities with the research group include GMO and radiochemistry laboratories.

Kort præsentation

Protein and nucleic acid structures and development of their synthetic modification as tools to investigate aspects of biological chemistry

 

Scientific interests and techniques:

Bioinorganic, inorganic and physical chemistry; in particular:

  • Understanding the chemistry, function, and structural dynamics of biological macromolecules with particular regard to the role of metal ions
  • Metal ion uptake and regulation in biological systems
  • Peptide and protein (mis-)folding and self-assembly
  • Ordered systems and chirality
  • Circular and linear dichroism spectroscopy
  • Absorbance, fluorescence, and NMR spectroscopy including X nuclei
  • Small molecule dynamics and photophysics and applied computational chemistry

 

Main scientific equipment:

 Jasco J-815 spectropolarimeter with capabilities for CD, fluorescence, MCD (1.5 T), stopped-flow kinetics, automated titration, and flow linear dichroism spectroscopy.

  • Jasco FP-6300 Spectrofluorometer, Shimadzu UV-2401PC UV-VIS and Shimadzu UV-3600 UV-VIS-NIR, liquid nitrogen cryostats and an extensive collection of optical cells for various purposes.
  • Nicolet FT-IR for solid, liquid and gas analysis and other instruments for vibrational spectroscopy.
  • Joint facilities with the research group include GMO and radiochemistry laboratories.

CV

Present affiliation and contact information:

 

Associate Professor, Biological Chemistry Section

Department of Chemistry, Faculty of Science

University of Copenhagen

Universitetsparken 5, DK-2100 Copenhagen Ø, Denmark

E-mail: [email protected], Phone: +45 31126051, Office: C208

 

1993

1999

BSc studies in chemistry and environmental biology at Roskilde University, Denmark.

MSc degree in chemistry and environmental biology (double major) from The Department of Life Sciences and Chemistry at Roskilde University. Thesis work involving application of optical spectroscopy in biological systems; FT-IR, Raman and linear dichroism of small-molecule – DNA interactions.

2003

August 29th awarded Ph.D. degree in bioinorganic chemistry from the Chemistry Department at the Royal Veterinary and Agricultural University. Supervised by Professor Erik Larsen in the Bioinorganic Chemistry Group on the application of spectroscopy and theoretical methods (DFT and TD-DFT) in the study of structure and function of proteins and model compounds of metalloproteins and other optically active compounds. Experimental synchrotron radiation (SR) based circular dichroism (CD) spectroscopy carried out visiting the Institute for Storage Ring Facilities, Aarhus University, Denmark.

2003

Post doc researcher at the Danish Veterinary Institute; funding by DJVF. Molecular modeling and docking studies of β-lactamase enzymes and inhibitors.

2004

Assistant research professor at the Quantum Protein Centre, Physics Department, Technical University of Denmark. Research on vibrational circular dichroism (VCD) spectroscopy.

2004

Assistant professor at Department of Natural Sciences, Royal Veterinary and Agricultural University in the Bioinorganic Chemistry Group. Research on absorption, CD and MCD spectroscopy of (metallo)-protein, model compounds and natural products, as well as SR-CD and VCD spectroscopy, and application of DFT methods for prediction of structure and spectroscopic properties.

2005

Diploma in Educational Studies for assistant professors, Royal Veterinary and Agricultural University.

2007

Associate professor at the Department of Natural Sciences, Faculty of Life Sciences, University of Copenhagen in the Bioinorganic Chemistry Group. Multiple research visits to the synchrotron ASTRID at Aarhus University for SR-CD and SR-LD spectroscopy. Continuous involvement in the establishment of a laboratory at CERN with a total of eight visits to the ISOLDE facility at CERN, Switzerland, to establish and utilize perturbed angular correlation spectroscopy for bioinorganic chemistry.

2008

Co-applicant for the NP3 project at LIFE for the study of the nanoscale properties of peptides and proteins in collaboration with Novo-Nordisk A/S. Involvement in the design of biomolecule variants, computational modelling, spectroscopy, and bioinorganic chemistry of the projects.

2012-

 

2016-

Associate professor in the Biophysical and of Bioinorganic Chemistry Group at the Department of Chemistry, Faculty of Science, University of Copenhagen.

Following department reorganization, now associate professor in the Section for Biological Chemistry at the Department of Chemistry, Faculty of Science, University of Copenhagen.

  

Emneord

  • Bioinformatik
  • Kemi
  • Kinetik
  • Spektroskopi
  • Det Natur- og Biovidenskabelige Fakultet
  • Fluorescence Spectroscopy
  • Bioinorganic chemistry
  • Circular Dichroism
  • Nucleic acids
  • Nanobiovidenskab og miljønanoteknologi

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