Rasmus Prætorius Clausen

Rasmus Prætorius Clausen offentligt CV

Fastnet+4535336566
E-mailracsund.kudk
Webstedhttps://drug.ku.dk/

Universitetsparken 2
2100 København Ø

Kort præsentation

neuromedicinalkemi
biostrukturbaserede SAR-studier
organisk syntese
udvikling af NMDA receptor ligander

Uddannelse (Akademiske kvalifikationer)

PhD, Organisk Kemi, Silicon in Organic Chemistry: New Tri- and Tetraalkoxysilanes, Aarhus Universitet

Dimissionsdato: 28 okt. 1999

Cand. Scient., Kemi-Cellebiologi, Syddansk Universitet (SDU)

Dimissionsdato: 19 sep. 1994

102 Tidsskriftartikel
11 Bidrag til bog/antologi
10 Konferenceabstrakt i tidsskrift
5 Review
Mere

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
Leurs, U., Klein, A. B., McSpadden, E. D., Griem-Krey, N., Solbak, S. M. Ø., Houlton, J., Villumsen, I. S., Vogensen, S. B., Hamborg, L., Gauger, S. J., Palmelund, L. B., Larsen, A. S. G., Shehata, M. A., Kelstrup, C. D., Olsen, J. V., Bach, A., Burnie, R. O., Kerr, D. S., Gowing, E. K. & Teurlings, S. M. W. & 9 flere, Chi, C. C., Gee, C. L., Frølund, B., Kornum, B. R., van Woerden, G. M., Clausen, R. P., Kuriyan, J., Clarkson, A. N. & Wellendorph, P., 2021, I: Proceedings of the National Academy of Sciences of the United States of America. 118, 31, 9 s., e2108079118.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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39 Citationer (Scopus)
Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity
Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Rouzbeh, N., Liu, N., Bunch, L., Hansen, K. B. & Clausen, R. P., 2022, I: Journal of Medicinal Chemistry. 65, 1, s. 734-746
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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10 Citationer (Scopus)
Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists
Maolanon, A., Papangelis, A., Kawiecki, D., Mou, T. C., Syrenne, J. T., Yi, F., Hansen, K. B. & Clausen, R. P., 2021, I: European Journal of Medicinal Chemistry. 212, 17 s., 113099.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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3 Citationer (Scopus)

51 Downloads (Pure)
Improved synthetic route for the GluN2-specific NMDA receptor glycine site agonist AICP
Zhao, F., Rouzbeh, N., Hansen, K. B. & Clausen, R. P., 31 mar. 2020, I: Tetrahedron Letters. 61, 12, 4 s., 151653.
Publikation: Bidrag til tidsskrift › Letter › peer review

6 Citationer (Scopus)
Novel binding mode for negative allosteric NMDA receptor modulators
Lotti, J. S., Syrenne, J. T., Benton, A. J., Al-Mousawi, A., Cornelison, L. E., Trolinder, C. J., Yi, F., Zhang, Z., Yates-Hansen, C. K., McClelland, L. J., Bosco, J., Rau, A. R., Clausen, R. P. & Hansen, K. B., 2026, I: The Journal of general physiology. 158, 1, 22 s., e202513872.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Design of (R)-3-(5-Thienyl)carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity
Zhao, F., Atxabal, U., Mariottini, S., Yi, F., Lotti, J. S., Layeux, M. S., Currier, C. C., Maderia, M. P., Cornelison, L. E., Anderson, C. M., Schultz, E. P., Zhang, Z., Jiang, L., Gao, Z., Liu, N., Woodahl, E. L., Bunch, L., Hansen, K. B. & Clausen, R. P., 2025, I: Journal of Medicinal Chemistry. 68, 3, s. 3572–3590
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Evaluation of allosteric NMDA receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling
Lotti, J. S., Jones, J., Farnsworth, J. C., Yi, F., Zhao, F., Menniti, F. S., Volkmann, R. A., Clausen, R. P. & Hansen, K. B., 2025, I: Molecular Pharmacology. 106, 5, 17 s., 100004.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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1 Citationer (Scopus)

26 Downloads (Pure)
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs
Bechthold, E., Grey, L., Diamant, E., Schmidt, J., Steigerwald, R., Zhao, F., Hansen, K. B., Bunch, L., Clausen, R. P. & Wünsch, B., 2023, I: Biological Chemistry. 404, 4, s. 255-265
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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3 Citationer (Scopus)

Rasmus Prætorius Clausen

Personlig profil

Kort præsentation

Uddannelse (Akademiske kvalifikationer)

Samarbejde og topforskningsområder i de sidste fem år

Dyk ned i detaljerne

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

Stereoselective synthesis of novel 2′-(S)-CCG-IV analogues as potent NMDA receptor agonists

Improved synthetic route for the GluN2-specific NMDA receptor glycine site agonist AICP

Novel binding mode for negative allosteric NMDA receptor modulators

Design of (R)-3-(5-Thienyl)carboxamido-2-aminopropanoic Acid Derivatives as Novel NMDA Receptor Glycine Site Agonists: Variation in Molecular Geometry to Improve Potency and Augment GluN2 Subunit-Specific Activity

Evaluation of allosteric NMDA receptor modulation by GluN2A-selective antagonists using pharmacological equilibrium modeling

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

Rasmus Prætorius Clausen

Personlig profil

Kort præsentation

Uddannelse (Akademiske kvalifikationer)

Samarbejde og topforskningsområder i de sidste fem år

Publikation