Personlig profil
Kort præsentation
- Born in 1979 in Sousse, Tunisia. I am half Tunisian and half Danish. I have lived in Denmark since 1998.
- Married. 2 Children born in 2011 and 2015.
- Academic degreees: BSc in Biology, MSc and PhD
For almost 15 years in academia, I have been involved in fundamental research within ion channel physiology and for the past 5 years, in ion channel pharmacology and drug screening as part-time Research Scientist at the Danish biotech company Acesion Pharma.
I am involved in diverse projects in the ion channel group by contributing mainly with my knowledge in ion channel electrophysiology as well my technical skills and hands on experience with conventional and automated patch clamp technique. My main focus is studying the role of specific potassium channels in cardiac fibrosis during atrial fibrillation by using different in vitro techniques such as electrophysiology, cell culture, protein biochemistry and proliferation assays.
Primære forskningsområder
Ion channel regulation, Heart arrhythmias, cardiac fibrosis, electrophysiology, drug screening, in vitro pharmacology.
CV
Work and Education
March 2018-present Assistant professor (half time position), Ion channel group, Department of Biomedical Sciences
2013-present Research Scientist (half time position) in the Danish Biotech company Acesion Pharma
2013-2018 Postdoc (half time position) in The Ion Channel Group, Department of Biomedical Sciences
2012-2013 Research Assistant in the Ion Channel Group
March 2011 Research Assistant at the Department of Neuroscience Drug Discovery, Lundbeck, Copenhagen, Denmark
January 2011 Research Assistant NeuroSearch A/S
2007-2010 PhD at the Department of Biology, Faculty of Science, University of Copenhagen
2003-2007 MSc at Department of Biology, Faculty of Science, University of Copenhagen.
1999-2003 Bachelor degree in Biology, University of Copenhagen
1998 Scientific graduate from high school in Tunisia (1998)
Abroad stay
2006 Three months at Centro Estudios Cientificos de Santiago (C.E.C.S) at the Department of Biophysics and Molecular Biology, Valdivia, Chile as part of my master’s thesis. Supervisor: Prof. Ramon Latorre.
2004-2005 Erasmus student in Paris ”Laboratoire de Biologie Moleculaire et Cellulaire de la Secretion”, Centre Nationale de Recherche Scientifique, CNRS. Supervisor: Prof. Claire Desnos.
Grants & Awards
2013 Travel Grant from “Hjerteforeningen” to participate in the 45th Sandbjerg meeting on Membrane Transport (May 27-29)
2007-2010 Ph.D. stipend, Faculty of science, University of Copenhagen.
2007 Conference Grant (for oral presentation at FASEB Summer research Conference in Snowmass, Colorado: Ion channel regulation 2007).
2005-2006 The Oticon Foundation (100.000 DKK for master program)
2004 Knud Højgårds fond and the Oticon foundation (Travel grants for the abroad study in Paris 20.000 DKK)
Emneord
- Det Sundhedsvidenskabelige Fakultet
- Ion kanaler og deres regulering
- elektrofysiologi
- farmakologi
- hjertearrytmi
- fibrose i hjertet
Samarbejde og topforskningsområder i de sidste fem år
Publikation
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NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide
Yan, Y., Abildgaard, L., Skarsfeldt, M. A., Bomholtz, S. H., Sørensen, U., Holst, A. G., Grunnet, M., Diness, J. G. & Bentzen, B. H., 2025, I: IJC Heart and Vasculature. 59, 8 s., 101699.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil20 Downloads (Pure) -
Whole-Exome Sequencing Implicates Neuronal Calcium Channel with Familial Atrial Fibrillation
Vad, O. B., Yan, Y., Denti, F., Ahlberg, G., Refsgaard, L., Bomholtz, S. H., Santos, J. L., Rasmussen, S., Haunsø, S., Svendsen, J. H., Christophersen, I. E., Schmitt, N., Olesen, M. S. & Bentzen, B. H., 2022, I: Frontiers in Genetics. 13, 8 s., 806429.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil3 Citationer (Scopus)59 Downloads (Pure) -
Functional phenotype variations of two novel Kv 7.1 mutations identified in patients with Long QT syndrome
Hammami Bomholtz, S., Refaat, M., Buur Steffensen, A., David, J.-P., Espinosa, K., Nussbaum, R., Wojciak, J., Hjorth Bentzen, B., Scheinman, M. & Schmitt, N., 2020, I: Pacing and Clinical Electrophysiology. 43, 2, s. 210-216 7 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
5 Citationer (Scopus) -
Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia
Diness, J. G., Abildgaard, L., Bomholtz, S. H., Skarsfeldt, M. A., Edvardsson, N., Sørensen, U. S., Grunnet, M. & Bentzen, B. H., 2020, I: Frontiers in Pharmacology. 11, 10 s., 749.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil4 Citationer (Scopus)84 Downloads (Pure) -
Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man
Bentzen, B. H., Bomholtz, S. H., Simó-Vicens, R., Folkersen, L., Abildgaard, L., Speerschneider, T., Muthukumarasamy, K. M., Edvardsson, N., Sørensen, U. S., Grunnet, M. & Diness, J. G., 2020, I: Frontiers in Pharmacology. 11, 610.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil23 Citationer (Scopus)126 Downloads (Pure) -
The KCa2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts
Kirchhoff, J. E., Skarsfeldt, M., Muthukumarasamy, K. M., Simó-Vicens, R., Bomholtz, S. H., Abildgaard, L., Jespersen, T., Sørensen, U. S., Grunnet, M., Bentzen, B. H. & Diness, J. G., 2019, I: Frontiers in Pharmacology. 10, 13 s., 668.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil11 Citationer (Scopus)217 Downloads (Pure) -
2,6-Bis(2-Benzimidazolyl)Pyridine (BBP) Is a Potent and Selective Inhibitor of Small Conductance Calcium-Activated Potassium (SK) Channels
Simó-Vicens, R., Bomholtz, S. H., Sørensen, U. S. & Bentzen, B. H., 3 dec. 2018, I: Frontiers in Pharmacology. 9, 1409.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil4 Citationer (Scopus)293 Downloads (Pure) -
Atrium-specific ion channels in the zebrafish: A role of Iin atrial repolarization
Skarsfeldt, M. A., Bomholtz, S. H., Lundegaard, P. R., Lopez-Izquierdo, A., Tristani-Firouzi, M. & Bentzen, B. H., jul. 2018, I: Acta Physiologica (Print). 223, 3, 17 s., e13049.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
12 Citationer (Scopus)