Personlig profil
Kort præsentation
Henrik Semb's research focus on elucidating basic mechanism in morphogenesis and how tissue architecture controls cell lineage commitment by using a combination of in vivo and in vitro genetic and cell biological experimental tools. Pancreas organogenesis in the mouse is used as model. We also use human pluripotent stem cells (hESCs/hiPSCs) as tools to study human pancreatic beta cell development and beta cell dysfunction in vitro as well as a source for transplantable beta cells in type 1 diabetes therapy.
For more information please visit the following webpages:
About Henrik Semb: http://danstem.ku.dk/people/semb_staff/semb/
Emneord
- Det Sundhedsvidenskabelige Fakultet
Samarbejde og topforskningsområder i de sidste fem år
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Real-time imaging reveals new mechanisms for pancreatic ductal establishment and remodeling
Jackson, A. L., Heilmann, S., Agerskov, R., Ebeid, C., Krivokapic, J. M., Romero Herrera, J. A., Semb, H. & Nyeng, P., 2026, I: The Journal of Cell Biology. 225, 3, 40 s., e202409022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation
Ebeid, C., Rump, A., Tian, C., Mamidi, A., De Arcangelis, A., Gradwohl, G. & Semb, H., 2025, I: EMBO Reports. 26, s. 5877–5904Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics
Tiemann, U., Tian, C., Hermann, F., Proks, M., Skovgaard, E., Kulik, I., Di, Y., Sedzinski, J. & Semb, T. H., 2025, I: Developmental Cell. 60, 13, s. 1871-1883, e1-e5Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Protocol for in vitro modeling of specification and morphogenesis of early pancreas development using human pluripotent stem cell-based organoid differentiation
Tian, C., Tiemann, U., Hermann, F. & Semb, H., 2025, I: STAR Protocols. 6, 2, 17 s., 103834.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage
Tian, C., Rump, A., Ebeid, C., Mamidi, A. & Semb, H., 2025, I: Stem Cell Reports. 20, 4, 10 s., 102444.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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An insulin hypersecretion phenotype precedes pancreatic β cell failure in MODY3 patient-specific cells
Hermann, F. M., Kjærgaard, M. F., Tian, C., Tiemann, U., Jackson, A., Olsen, L. R., Kraft, M., Carlsson, P. O., Elfving, I. M., Kettunen, J. L. T., Tuomi, T., Novak, I. & Semb, H., 2023, I: Cell Stem Cell. 30, 1, s. 38-51.e8 23 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Flow cytometry detection of surface and intracellular antigens in pancreas from a single mouse embryo
Nyeng, P., Dela Cruz, G. V. & Semb, T. H., 2021, I: STAR Protocols. 2, 3, 21 s., 100636.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Quantifying spatial position in a branched structure in immunostained mouse tissue sections
Heilmann, S., Semb, T. H. & Nyeng, P., 2021, I: STAR Protocols. 2, 4, 31 s., 100806.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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