Personlig profil
Mulige interessekonflikter
- I have received travel grants from the following funder: Otto Mønsted Foundation (10,000 DKK), Oticon Foundation (9,500 DKK), Engineer Valdemar Selmer Trane and Mrs. Elisa Trane Foundation (5,000 DKK), DTU Travel Grant (3,000 DKK), Lundbeck Travel Stipends (12,000 DKK), Valdemar Selmer Trane and Mrs. Elisa Trane Foundation (6,000 DKK), Augustinus Fonden (14,000 DKK), Knud Højgaards Fond (13,000 DKK), Borgervennen (10,000 DKK)
Kort præsentation
I work as an associate professor in the Department of Food Science at the University of Copenhagen, where I specialize in developing bacteriophage-based therapies for treating gut-related diseases. With a recently awarded early-career grant (6 million DKK), I am currently working on starting my own research with in this area.
Interesseområder
I'm especially interested to increase the understanding of how the complex interactions between the gut microbiota and the mammalian host influences physical parameters. It is generally accepted that imbalances in the gut microbiota are associated to various diseases.
So in my research I have had a special focus on how bacteriophages (phages, viruses that infect bacteria) harbor the potential as a therapeutic tool to reshape an unhealthy gut microbiota into a healthy gut microbiota that is beneficial for the host. In general, I believe that phages ability to infect and kill specific bacteria have an unused potential to solve several challenges within the medical as well as food sciences, of which is the area of research that I desire to explore even more.
Aktuel forskning
Our gut microbiome consists primarily of bacteria and bacterial viruses (bacteriophages). An imbalance in the gut microbiome is linked to various diseases such as colorectal cancer, obesity, depression, and inflammatory bowel disease. Treating these conditions by restoring the balance in the gut microbiome, often through fecal transplantation (transfer of feces from a healthy donor to a patient), has been attempted, but widespread use is unlikely due to varying effectiveness and the risk of infections. However, recent studies indicate that bacteriophages play a crucial role in the success of fecal transplantation. PhageX is based on the bold hypothesis that treatment with bacteriophages can not only be more effective than fecal transplantation, but can also be transformed into a reproducible bacteriophage therapy, ensuring a low risk of infection from harmful microbes in the donor.
https://dff.dk/en/apply/supported-research/research-leaders/research-leader-2023/torben-solbeck-rasmussen
Undervisnings- og vejledningsområder
I'm currently contributing to teaching and supervising in the following courses:
- The Human Microbiome
- Fødevareproduktion, samfund og sundhed
- Designing Nutritious Future Dairy Products and Alternatives
- Main supervisor for 1 PhD student and co-supervising 2 PhDs
- Several master students performing their thesis
Uddannelse (Akademiske kvalifikationer)
Microbiology, PhD, Bacteriophages – A key component in shaping a healthy gut microbiome, Københavns Universitet
okt. 2016 → jul. 2020
Dimissionsdato: 3 jul. 2020
Biotechnology, Msc - Engineer, Characterisation and control of the optical response of different Flavobacterium col44 strains
30 aug. 2011 → 30 jun. 2016
Dimissionsdato: 30 jun. 2016
Classical guitar (Chord instruments), BA mus.
Dimissionsdato: 30 jun. 2011
Eksterne ansættelser
Committee member, The Young Academy of Technology, science, and Innovation (YATSI)
sep. 2024 → sep. 2029
Early Career Team Member , Copenhagen Gut Microbiome Hub
jun. 2023 → …
Emneord
- Det Natur- og Biovidenskabelige Fakultet
- Bacteriophage-host interactions
- Fecal microbiota transplantation
- Bacteriophage therapy
- Animal models
Samarbejde og topforskningsområder i de sidste fem år
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Overcoming donor variability and risks associated with fecal microbiota transplants through bacteriophage-mediated treatments
Rasmussen, T. S., Mao, X., Forster, S., Larsen, S. B., Von Münchow, A., Tranæs, K. D., Brunse, A., Larsen, F., Mejia, J. L. C., Adamberg, S., Hansen, A. K., Adamberg, K., Hansen, C. H. F. & Nielsen, D. S., 2024, I: Microbiome. 12, 24 s., 119.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil26 Citationer (Scopus)51 Downloads (Pure) -
Reproducible chemostat cultures to minimize eukaryotic viruses from fecal transplant material
Adamberg, S., Rasmussen, T. S., Larsen, S. B., Mao, X., Nielsen, D. S. & Adamberg, K., 2024, I: iScience. 27, 8, 15 s., 110460.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil1 Citationer (Scopus)24 Downloads (Pure) -
Transfer of modified gut viromes improves symptoms associated with metabolic syndrome in obese male mice
Mao, X., Larsen, S. B., Zachariassen, L. S. F., Brunse, A., Adamberg, S., Mejia, J. L. C., Larsen, F., Adamberg, K., Nielsen, D. S., Hansen, A. K., Hansen, C. H. F. & Rasmussen, T. S., 2024, I: Nature Communications. 15, 19 s., 4704.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil22 Citationer (Scopus)41 Downloads (Pure) -
Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model
Rasmussen, T. S., Mentzel, C. M. J., Kot, W., Castro-Mejiá, J. L., Zuffa, S., Swann, J. R., Hansen, L. H., Vogensen, F. K., Hansen, A. K. & Nielsen, D. S., 2020, I: Gut. 69, 12, s. 2122-2130 9 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
205 Citationer (Scopus) -
Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice
Rasmussen, T. S., Mentzel, C. M. J., Danielsen, M. R., Jakobsen, R. R., Zachariassen, L. S. F., Castro Mejia, J. L., Brunse, A., Hansen, L. H., Hansen, C. H. F., Hansen, A. K. & Nielsen, D. S., 2023, I: Gut Microbes. 15, 1, 21 s., 2208504.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil26 Citationer (Scopus)95 Downloads (Pure) -
CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice
Rasmussen, T. S., Koefoed, A. K., Deng, L., Muhammed, M. K., Rousseau, G. M., Kot, W., Sprotte, S., Neve, H., Franz, C. M. A. P., Hansen, A. K., Vogensen, F. K., Moineau, S. & Nielsen, D. S., 2023, I: ISME Journal. 17, s. 432–442Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Fil4 Citationer (Scopus)84 Downloads (Pure) -
Mucofilm: a nexus for phage-microbiome interactions in gut ecology
Mortensen, A. S., Nielsen, D. S., Røder, H. L. & Rasmussen, T. S., 2025, I: Applied and Environmental Microbiology. 91, 11, 6 s., e01269-25.Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
Åben adgangFil8 Downloads (Pure) -
The Impact of Human Milk Oligosaccharides on Antibiotic-Induced Microbial Dysbiosis and Gut Inflammation in Mice: Antibiotics
Christensen, K. R., Rasmussen, T. S., Mentzel, C. M. J., Lanng, S. K., Meloni, E. T. G., Bertram, H. C., Hansen, C. H. F. & Kornerup Hansen, A., 2025, I: Antibiotics. 14, 5, 22 s., 488.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
Åben adgangFil7 Downloads (Pure)
Priser
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Sapere Aude - PhageX: Next-generation bacteriophage therapy for treating gut-related diseases
Rasmussen, T. S. (Modtager), 1 dec. 2023
Pris: Priser, stipendier, udnævnelser