Personlig profil
Kort præsentation
Manufacturing and clinical use of PET radiopharmaceuticals - Huynh Group
Our group is located at the Department of Nuclear Medicine, Herlev Hospital, University of Copenhagen, Denmark. We develop and manufacture PET radiopharmaceuticals in close collaboration with the physicians for diagnosis of cancers and neurological diseases, and to investigate abnormalities in organs. In addition, development of radiopharmaceuticals for treatment of prostate cancer is also conducted in the group.
Primære forskningsområder
Research Focus
Our projects focus primarily on research and development of radiopharmaceuticals for clinical applications, using mainly carbon-11 and fluorine-18 PET nuclides for labeling.
- Development of PET tracers for diagnosis of Alzheimer’s disease, primary hyperaldosteronism, and parathyroid adenoma.
- Optimization of PET tracers for imaging and treatment of prostate cancer.
- New methodologies with clinical relevance to the field of PET radiochemistry.
- Production of radioisotopes.
If you are looking for a master project within the mentioned projects and would like to work in a hospital and close to patients, you are welcome to contact me.
Undervisnings- og vejledningsområder
GMP in Practice
Production of radiopharmaceuticals for human use is performed under Good Manufacturing Practice (GMP). GMP experience is therefore highly relevant, and many companies require this competence from their employees. Thus, if you are interested in a GMP internship to learn about GMP in practice, then you are welcome to contact me.
Uddannelse (Akademiske kvalifikationer)
Medicinal Chemistry, M.Sc., Design and Synthesis of Beta-Amyloid Fibril-Binding Compounds, Aarhus Universitet
Dimissionsdato: 1 aug. 2008
Medicinal Chemistry, phd., Design and synthesis of subtype selective ligands for the human excitatory amino acid transporters (EAATs)
1 jan. 2009 → 1 jan. 2012
Dimissionsdato: 1 jan. 1970
Eksterne ansættelser
Ledende radiokemiker, Copenhagen University Hospital - Herlev and Gentofte
1 sep. 2013 → …
Emneord
- Det Sundhedsvidenskabelige Fakultet
- Radiopharmaceuticals
- PET Tracers
- Cancers
- Medicinal Chemistry
- Dementia
- Radioisotopes
- Good Manufacturing Practice (GMP)
- Good Clinical Practice
- Clinical Development
- Production
- Qualified Person
Samarbejde og topforskningsområder i de sidste fem år
Publikation
- 16 Tidsskriftartikel
-
Multicenter Experience with Good Manufacturing Practice Production of [11C]PiB for Amyloid Positron Emission Tomography Imaging
Andersen, A. B. A., Lehel, S., Grove, E. K., Langkjaer, N., Fuglø, D. & Huynh, T. H. V., 2024, I: Pharmaceuticals. 17, 2, 217.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgangFil16 Downloads (Pure) -
GMP production of 6-[18F]Fluoro-L-DOPA for PET/CT imaging by different synthetic routes: a three center experience
Andersen, V. L., Soerensen, M. A., Dam, J. H., Langkjaer, N., Petersen, H., Bender, D. A., Fugloe, D. & Huynh, T. H. V., 2021, I: EJNMMI Radiopharmacy and Chemistry. 6, 21.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Åben adgang11 Citationer (Scopus) -
Automated synthesis of 68Ga/177Lu-PSMA on the Trasis miniAllinOne
Sørensen, M. A., Andersen, V. L., Hendel, H. W., Vriamont, C., Warnier, C., Masset, J. & Huynh, T. H. V., 2020, I: Journal of Labelled Compounds and Radiopharmaceuticals. 63, 8, s. 393-403 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
17 Citationer (Scopus) -
68 Ga-PSMA-PET/CT in comparison with 18 F-fluoride-PET/CT and whole-body MRI for the detection of bone metastases in patients with prostate cancer: a prospective diagnostic accuracy study
Dyrberg, E., Hendel, H. W., Huynh, T. H. V., Klausen, T. W., Løgager, V. B., Madsen, C., Pedersen, E. M., Pedersen, M. & Thomsen, H. S., 2019, I: European Radiology. 29, 3, s. 1221-1230 10 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
82 Citationer (Scopus) -
Design and Synthesis of a Series of L-trans-4-Substituted Prolines as Selective Antagonists for the Ionotropic Glutamate Receptors Including Functional and X-ray Crystallographic Studies of New Subtype Selective Kainic Acid Receptor Subtype 1 (GluK1) Antagonist (2S,4R)-4-(2-Carboxyphenoxy)pyrrolidine-2-carboxylic Acid
Krogsgaard-Larsen, N., Delgar, C., Koch, K., Brown, P. M. G. E., Møller, C., Han, L., Huynh, T. H. V., Hansen, S. W., Nielsen, B., Bowie, D., Pickering, D. S., Kastrup, J. S. J., Frydenvang, K. A. & Bunch, L., 2017, I: Journal of Medicinal Chemistry. 60, 1, s. 441-457 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
6 Citationer (Scopus) -
Bioavailability studies and in vitro profiling of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-102)
Haym, I., Huynh, T. H. V., Hansen, S. W., Pedersen, M. H. F., Ruiz, J. A., Erichsen, M. N., Gynther, M., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Bastlund, J. F., Bundgaard, C., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, I: ChemMedChem. 11, 4, s. 403-419 17 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
13 Citationer (Scopus) -
New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
Huynh, T. H. V., Erichsen, M. N., Tora, A. S., Goudet, C., Sagot, E., Assaf, Z., Thomsen, C., Brodbeck, R., Stensbol, T. B., Bjorn-Yoshimoto, W. E., Nielsen, B., Pin, J.-P., Gefflaut, T. & Bunch, L., 2016, I: Journal of Medicinal Chemistry. 59, 3, s. 914-924 11 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
14 Citationer (Scopus) -
New insights into the structure-activity-relationship of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitors UCPH-101 and UCPH-102
Hansen, S. W., Erichsen, M. N., Huynh, T. H. V., Ruiz, J. A., Haym, I., Bjørn-Yoshimoto, W. E., Abrahamsen, B., Hansen, J., Storgaard, M., Eriksen, A. L., Jensen, A. A. & Bunch, L., 2016, I: ChemMedChem. 11, 4, s. 382-402 21 s.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
5 Citationer (Scopus)