Personlig profil
Kort præsentation
The overarching goals for Clausen Group and Copenhagen Center for Glycomics (CCG) are to identify diseases caused by defects in glycosylation and to uncover novel functions of glycosylation.
Technical barriers have left the glycomics field under-explored with a huge potential for discovery and biomedical applications. In Clausen group we are developing novel enabling technologies to overcome these barriers using a genetic approach to glycomics. Our unique strategies to glycomics are based on a genetic entry point and designed for open-ended and opportunistic Ome-wide discovery. The grand idea is to transform glycosciences from a field largely only approachable to specialists into a mainstream “Omics” field approachable to non-specialists with an ease comparable to the genome and proteome fields today. Our specific discovery programs GlycoDisplay, GlycoCRISPR, GlycoDesign, and GlycoView are developing unique reagents, tools and community resources that will help bring glycosciences into a new phase where studying the biology of glycans becomes as intuitive as building with “Lego”.
Emneord
- Det Sundhedsvidenskabelige Fakultet
- Glycobiology
- Glycoproteomics
- Gene precise editing
- Molcular biology
Samarbejde og topforskningsområder i de sidste fem år
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Discovery of a secreted <i>Bacteroides fragilis</i> mucinase that cleaves mucins with bis-T O-glycans through a carbohydrate binding module-dependent mechanism
Narimatsu, Y., Pleguezuelos-Manzano, C., Hornikx, D., Goerdeler, F., Jaroentomeechai, T., Flores, K., Narimatsu, S., Boot, C., Hansen, L., Durbesson, F., Vincentelli, R., Comstock, L., Clevers, H., Taleb, V., Corzana, F., Henrissat, B., Clausen, H., Hurtado-Guerrero, R. & Bull, C., 2026, I: Gut Microbes. 18, 1, 25 s., 2644983.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Plant fucosyltransferase FUT11 distorts the sugar acceptor to catalyze via a transient oxocarbenium intermediate mechanism
Taleb, V., Sanz-Martínez, I., Serna, S., Bort-Griñó, M., Narimatsu, Y., Furukawa, S., Reichardt, N. C., Clausen, H., Merino, P. & Hurtado-Guerrero, R., 2026, I: Nature Communications. 17, 1, 18 s., 1960.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Presentation Is Essential for Glycan-Lectin Recognition at the Molecular and Cellular Levels: The Interaction of Tumor-Associated O-Glycans with the Macrophage Galactose-Type Lectin
Grosso, A. S., Diniz, A., Soares, C. O., Goerdeler, F., Gimeno, A., Coelho, P., Coelho, H., Lima, C. D. L., Pinheiro, B., Lete, M. G., Garcia-Martin, F., Jaroentomeechai, T., Gomes, J., Reis, C. A., Westerlind, U., Corzana, F., Palma, A. S., Clausen, H., Jimenez-Barbero, J. & Van Vliet, S. J. & 2 flere, , 2026, I: JACS Au. 6, 1, s. 82-94Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells
Li, Z., Chawla, H., Di Vagno, L., Ni Cheallaigh, A., Critcher, M., Sammon, D., Gonzalez-Rodriguez, E., Briggs, D. C., Chung, N., Chang, V., Mahoney, K. E., Cioce, A., Bineva-Todd, G., Wang, P.-Y., Liu, Y.-C., Murphy, L. D., Chen, Y.-H., Narimatsu, Y., Miller, R. L. & Willems, L. I. & 5 flere, , 2026, I: Nature Chemical Biology. 22, s. 612-621Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Apoptotic signaling by TNFR1 is inhibited by the α2-6 sialylation, but not α2-3 sialylation, of the TNFR1 N-glycans
Hwang, J., Rao, T. C., Tao, J., Sha, B., Narimatsu, Y., Clausen, H., Mattheyses, A. L. & Bellis, S. L., 2025, I: Journal of Biological Chemistry. 301, 1, 18 s., 108043.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Cell-based sialoglycan arrays for directly comparing influenza A virus receptor requirements for binding and infection
Liu, M., Wu, X., van de Garde, M. D. B., Narimatsu, Y., van Kuppeveld, F. J. M., Clausen, H., de Haan, C. A. M. & de Vries, E., 2025, I: iScience. 28, 6, 19 s., 112549.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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Differential O-glucose elongation on a specific EGF repeat within the canonical ligand binding domain negatively regulates DLL1-NOTCH1 signaling
Tsukamoto, Y., Aoki, K., Kama, Y., Hosokawa, H., Saiki, W., Tsukamoto, N., Kato, K., Hosokawa, Y., Sato, R., Uesugi, N., Fujita, Y., Fukazawa, K., Funada, D., Suzuki, F., Kurebayashi, Y., Urata, Y., Uchiyama, S., Wang, W., Minami, A. & Takahashi, T. & 4 flere, , 2025, I: Glycobiology. 35, 11, s. 25-25 P3-047.Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review
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Differential O-glucose elongation on a specific EGF repeat within the canonical ligand–binding domain regulates DLL1/4-NOTCH1 signaling
Tsukamoto, Y., Aoki, K., Kama, Y., Hosokawa, H., Saiki, W., Tsukamoto, N., Kato, K., Hosokawa, Y., Sato, R., Uesugi, N., Fujita, Y., Fukazawa, K., Funada, D., Suzuki, F., Kurebayashi, Y., Urata, Y., Uchiyama, S., Wang, W., Minami, A. & Takahashi, T. & 4 flere, , 2025, I: Proceedings of the National Academy of Sciences of the United States of America. 122, 43, 11 s., e2504827122.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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