ß(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

Henning Bundgaard; Chia-Chi Liu; Alvaro Garcia; Elisha J Hamilton; Yifei Huang; Karin K M Chia; Stephen N Hunyor; Gemma A Figtree; Helge Kildahl Rasmussen

doi:10.1161/CIRCULATIONAHA.110.964619

ß(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

Henning Bundgaard, Chia-Chi Liu, Alvaro Garcia, Elisha J Hamilton, Yifei Huang, Karin K M Chia, Stephen N Hunyor, Gemma A Figtree, Helge Kildahl Rasmussen

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

81 Citationer (Scopus)

Abstract

inhibition of L-type Ca(2+) current contributes to negative inotropy of ß(3) adrenergic receptor (ß(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the ß(3) AR in heart failure.

Originalsprog	Engelsk
Tidsskrift	Circulation
Vol/bind	122
Udgave nummer	25
Sider (fra-til)	2699-708
Antal sider	10
DOI	https://doi.org/10.1161/CIRCULATIONAHA.110.964619
Status	Udgivet - 2010

Adgang til dokumentet

10.1161/CIRCULATIONAHA.110.964619

Citationsformater

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title = "{\ss}(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification",

abstract = "inhibition of L-type Ca(2+) current contributes to negative inotropy of {\ss}(3) adrenergic receptor ({\ss}(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the {\ss}(3) AR in heart failure.",

author = "Henning Bundgaard and Chia-Chi Liu and Alvaro Garcia and Hamilton, {Elisha J} and Yifei Huang and Chia, {Karin K M} and Hunyor, {Stephen N} and Figtree, {Gemma A} and Rasmussen, {Helge Kildahl}",

year = "2010",

doi = "10.1161/CIRCULATIONAHA.110.964619",

language = "English",

volume = "122",

pages = "2699--708",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - ß(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification

AU - Bundgaard, Henning

AU - Liu, Chia-Chi

AU - Garcia, Alvaro

AU - Hamilton, Elisha J

AU - Huang, Yifei

AU - Chia, Karin K M

AU - Hunyor, Stephen N

AU - Figtree, Gemma A

AU - Rasmussen, Helge Kildahl

PY - 2010

Y1 - 2010

N2 - inhibition of L-type Ca(2+) current contributes to negative inotropy of ß(3) adrenergic receptor (ß(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the ß(3) AR in heart failure.

AB - inhibition of L-type Ca(2+) current contributes to negative inotropy of ß(3) adrenergic receptor (ß(3) AR) activation, but effects on other determinants of excitation-contraction coupling are not known. Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the ß(3) AR in heart failure.

U2 - 10.1161/CIRCULATIONAHA.110.964619

DO - 10.1161/CIRCULATIONAHA.110.964619

M3 - Journal article

SN - 0009-7322

SN - 1524-4539

SN - 1524-4571

VL - 122

SP - 2699

EP - 2708

JO - Circulation

JF - Circulation

IS - 25

ER -