11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue and prospective changes in body weight and insulin resistance

Juraj Koska, Barbora de Courten, Deborah J Wake, Saraswathy Nair, Brian R Walker, Joy C Bunt, Paska A Permana, Robert S Lindsay, P Antonio Tataranni

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17 Citationer (Scopus)

Abstract

Increased mRNA and activity levels of 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) in human adipose tissue (AT) are associated with obesity and insulin resistance. The aim of our study was to investigate whether 11betaHSD1 expression or activity in abdominal subcutaneous AT of non-diabetic subjects are associated with subsequent changes in body weight and insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)].
OriginalsprogEngelsk
TidsskriftObesity
Vol/bind14
Udgave nummer9
Sider (fra-til)1515-22
Antal sider8
ISSN1930-7381
DOI
StatusUdgivet - 1 sep. 2006

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