1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection

Karoline Bragstad; Cyril Jean-Marie Martel; Bent Aasted; Lars Peter Nielsen; Anders Fomsgaard

1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection

Karoline Bragstad, Cyril Jean-Marie Martel, Bent Aasted, Lars Peter Nielsen, Anders Fomsgaard

Publikation: Konferencebidrag › Poster › Forskning

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Abstract

Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.

Originalsprog	Engelsk
Publikationsdato	2008
Status	Udgivet - 2008
Begivenhed	European Influenza Conference - Vilamoura, Portugal Varighed: 14 sep. 2008 → 17 sep. 2008 Konferencens nummer: 3

Konference

Konference	European Influenza Conference
Nummer	3
Land/Område	Portugal
By	Vilamoura
Periode	14/09/2008 → 17/09/2008

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Citationsformater

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title = "1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection",

abstract = "Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.",

keywords = "Former LIFE faculty, DNA vaccine, Ferret, 1918",

author = "Karoline Bragstad and Martel, {Cyril Jean-Marie} and Bent Aasted and Nielsen, {Lars Peter} and Anders Fomsgaard",

year = "2008",

language = "English",

note = "null ; Conference date: 14-09-2008 Through 17-09-2008",

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TY - CONF

T1 - 1918 pandemic H1N1 DNA vaccine protects ferrets against 2007 H1N1 virus infection

AU - Bragstad, Karoline

AU - Martel, Cyril Jean-Marie

AU - Aasted, Bent

AU - Nielsen, Lars Peter

AU - Fomsgaard, Anders

N1 - Conference code: 3

PY - 2008

Y1 - 2008

N2 - Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.

AB - Influenza vaccines with the ability to induce immune responses cross-reacting with drifted virus variants would be of great advantage for vaccine development against seasonal and emerging new strains. We demonstrate that gene gun administrated DNA vaccine encoding HA and NA and/or NP and M proteins of the H1N1 pandemic virus from 1918 induce protection in ferrets against infection with a H1N1 (A/New Caledonia/20/99(H1N1)) virus which was included in the conventional vaccine for the 2006-2007 season. The viruses are separated by a time interval of 89 years and differ by 21.2% in the HA1 protein. These results suggest not only a unique ability of the DNA vaccines, but perhaps also natural infection, to induce cross-protective responses against even extremely drifted virus variants.

KW - Former LIFE faculty

KW - DNA vaccine

KW - Ferret

KW - 1918

M3 - Poster

Y2 - 14 September 2008 through 17 September 2008

ER -