A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Till Bartke; Anja Groth

doi:10.1080/23723556.2019.1605820

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

Till Bartke, Anja Groth

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

176 Downloads (Pure)

Abstract

Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

Originalsprog	Engelsk
Artikelnummer	1605820
Tidsskrift	Molecular & Cellular Oncology
Vol/bind	6
Udgave nummer	4
Antal sider	3
ISSN	2372-3556
DOI	https://doi.org/10.1080/23723556.2019.1605820
Status	Udgivet - 2019

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10.1080/23723556.2019.1605820Licens: CC BY-NC-ND

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaksForlagets udgivne version, 1,22 MBLicens: CC BY-NC-ND

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abstract = "Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.",

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AB - Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

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