Abstract
The production of biochemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Weizmannia coagulans species. So far, the genomes of 47 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of Carbohydrate-Active enZymes (CAZymes), secretion systems, and resistance mechanisms to environmental challenges. Moreover, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated (Cas) genes, was also analyzed. Overall, this study expands our understanding of the strain’s genomic diversity of W. coagulans to fully exploit its potential in biotechnological applications.
Originalsprog | Engelsk |
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Artikelnummer | 3135 |
Tidsskrift | International Journal of Molecular Sciences |
Vol/bind | 23 |
Udgave nummer | 6 |
Antal sider | 23 |
ISSN | 1661-6596 |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:Funding: This work was supported by PRIN 2017-PANACEA CUP:E69E19000530001 and by Good-byWaste: ObtainGOOD products–exploit BY-products–reduce WASTE, MIUR 2017-JTNK78.006, Italy. Novo Nordisk Foundation/Hallas-Moeller Ascending Investigator Grant to X.P. (NNF17OC0031154).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.