Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Cardiothoracic and Vascular Anesthesia |
| Vol/bind | 23 |
| Udgave nummer | 2 |
| Sider (fra-til) | 195-9 |
| Antal sider | 4 |
| ISSN | 1053-0770 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Acute-Phase Proteins; Aged; Biological Markers; Body Mass Index; Cohort Studies; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoblotting; Kidney Function Tests; Lipocalins; Male; Proto-Oncogene Proteins; Risk Factors; Stroke VolumeAdgang til dokumentet
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I: Journal of Cardiothoracic and Vascular Anesthesia, Bind 23, Nr. 2, 2009, s. 195-9.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - A comparison of urinary neutrophil gelatinase-associated lipocalin in patients undergoing on- versus off-pump coronary artery bypass graft surgery
AU - Wagener, Gebhard
AU - Gubitosa, Gina
AU - Wang, Shuang
AU - Borregaard, Niels
AU - Kim, Mihwa
AU - Lee, H Thomas
N1 - Keywords: Acute-Phase Proteins; Aged; Biological Markers; Body Mass Index; Cohort Studies; Coronary Artery Bypass; Coronary Artery Bypass, Off-Pump; Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoblotting; Kidney Function Tests; Lipocalins; Male; Proto-Oncogene Proteins; Risk Factors; Stroke Volume
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery. DESIGN: A matched cohort study. SETTING: A tertiary university hospital. PARTICIPANTS: Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump) matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine, Parsonnet score, ejection fraction, body mass index, and number of coronary artery grafts. INTERVENTIONS: None, observational. MEASUREMENTS AND MAIN RESULTS: Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before and immediately after surgery and then 3, 18, and 24 hours later. There were no differences in urinary NGAL at any time point between patients subjected to off-pump or on-pump CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery was 94.7 +/- 30.9 ng/mL compared with 122.7 +/- 57.0 ng/mL in patients with on-pump CABG surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were not different between the groups. CONCLUSIONS: Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery despite a very good match between the groups with respect to pre- and intraoperative risk factors.
AB - OBJECTIVE: The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery. DESIGN: A matched cohort study. SETTING: A tertiary university hospital. PARTICIPANTS: Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump) matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine, Parsonnet score, ejection fraction, body mass index, and number of coronary artery grafts. INTERVENTIONS: None, observational. MEASUREMENTS AND MAIN RESULTS: Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before and immediately after surgery and then 3, 18, and 24 hours later. There were no differences in urinary NGAL at any time point between patients subjected to off-pump or on-pump CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery was 94.7 +/- 30.9 ng/mL compared with 122.7 +/- 57.0 ng/mL in patients with on-pump CABG surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were not different between the groups. CONCLUSIONS: Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery despite a very good match between the groups with respect to pre- and intraoperative risk factors.
U2 - 10.1053/j.jvca.2008.11.018
DO - 10.1053/j.jvca.2008.11.018
M3 - Journal article
C2 - 19201208
SN - 1053-0770
VL - 23
SP - 195
EP - 199
JO - Journal of Cardiothoracic and Vascular Anesthesia
JF - Journal of Cardiothoracic and Vascular Anesthesia
IS - 2
ER -