A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros; Thomas Folkmann Hansen; David Westergaard; Ioannis Louloudis; Sebastian Kalamajski; Timo Röder; Palle Duun Rohde; Michael Schwinn; Line Harder Clemmensen; Maria Didriksen; Mette Nyegaard; Henrik Hjalgrim; Kaspar René Nielsen; Mie Topholm Bruun; Sisse Rye Ostrowski; Christian Erikstrup; Susan Mikkelsen; Erik Sørensen; Ole Birger Vestager Pedersen; Søren Brunak; Karina Banasik; Giuseppe Nicola Giordano; DBDS Genomic Consortium

doi:10.1038/s41598-024-51636-0

A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros, Thomas Folkmann Hansen, David Westergaard, Ioannis Louloudis, Sebastian Kalamajski, Timo Röder, Palle Duun Rohde, Michael Schwinn, Line Harder Clemmensen, Maria Didriksen, Mette Nyegaard, Henrik Hjalgrim, Kaspar René Nielsen, Mie Topholm Bruun, Sisse Rye Ostrowski, Christian Erikstrup, Susan Mikkelsen, Erik Sørensen, Ole Birger Vestager Pedersen, Søren BrunakKarina Banasik, Giuseppe Nicola Giordano, DBDS Genomic Consortium

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study,
we performed genome‑wide association studies of self‑reported social trust in n = 33,882 Danish
blood donors. We observed genome‑wide and local evidence of genetic similarity with other brain‑
related phenotypes and estimated the single nucleotide polymorphism‑based heritability of trust to
be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one
significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a
gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in
an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta‑
analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer
region. Overall, our work confirms that social trust is heritable, and provides an initial look into the
genetic factors that influence it

Originalsprog	Engelsk
Artikelnummer	1402
Tidsskrift	Scientific Reports
Vol/bind	14
Antal sider	12
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-024-51636-0
Status	Udgivet - 2024

Bibliografisk note

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10.1038/s41598-024-51636-0Licens: CC BY

FulltextForlagets udgivne version, 1,54 MBLicens: CC BY

Citationsformater

Sequeros, C. B., Hansen, T. F., Westergaard, D., Louloudis, I., Kalamajski, S., Röder, T., Rohde, P. D., Schwinn, M., Clemmensen, L. H., Didriksen, M., Nyegaard, M., Hjalgrim, H., Nielsen, K. R., Bruun, M. T., Ostrowski, S. R., Erikstrup, C., Mikkelsen, S., Sørensen, E., Pedersen, O. B. V., ... DBDS Genomic Consortium (2024). A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports, 14, [1402]. https://doi.org/10.1038/s41598-024-51636-0

A genome-wide association study of social trust in 33,882 Danish blood donors. / Sequeros, Celia Burgos ; Hansen, Thomas Folkmann; Westergaard, David; Louloudis, Ioannis; Kalamajski, Sebastian; Röder, Timo; Rohde, Palle Duun; Schwinn, Michael; Clemmensen, Line Harder; Didriksen, Maria; Nyegaard, Mette; Hjalgrim, Henrik; Nielsen, Kaspar René; Bruun, Mie Topholm; Ostrowski, Sisse Rye; Erikstrup, Christian; Mikkelsen, Susan; Sørensen, Erik; Pedersen, Ole Birger Vestager ; Brunak, Søren ; Banasik, Karina; Giordano, Giuseppe Nicola; DBDS Genomic Consortium.

I: Scientific Reports, Bind 14, 1402, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sequeros, CB , Hansen, TF, Westergaard, D, Louloudis, I, Kalamajski, S, Röder, T, Rohde, PD, Schwinn, M, Clemmensen, LH, Didriksen, M, Nyegaard, M, Hjalgrim, H, Nielsen, KR, Bruun, MT, Ostrowski, SR, Erikstrup, C, Mikkelsen, S, Sørensen, E, Pedersen, OBV , Brunak, S , Banasik, K, Giordano, GN & DBDS Genomic Consortium 2024, 'A genome-wide association study of social trust in 33,882 Danish blood donors', Scientific Reports, bind 14, 1402. https://doi.org/10.1038/s41598-024-51636-0

Sequeros, Celia Burgos ; Hansen, Thomas Folkmann ; Westergaard, David ; Louloudis, Ioannis ; Kalamajski, Sebastian ; Röder, Timo ; Rohde, Palle Duun ; Schwinn, Michael ; Clemmensen, Line Harder ; Didriksen, Maria ; Nyegaard, Mette ; Hjalgrim, Henrik ; Nielsen, Kaspar René ; Bruun, Mie Topholm ; Ostrowski, Sisse Rye ; Erikstrup, Christian ; Mikkelsen, Susan ; Sørensen, Erik ; Pedersen, Ole Birger Vestager ; Brunak, Søren ; Banasik, Karina ; Giordano, Giuseppe Nicola ; DBDS Genomic Consortium. / A genome-wide association study of social trust in 33,882 Danish blood donors. I: Scientific Reports. 2024 ; Bind 14.

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abstract = "Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.",

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AU - Sequeros, Celia Burgos

AU - Hansen, Thomas Folkmann

AU - Westergaard, David

AU - Louloudis, Ioannis

AU - Kalamajski, Sebastian

AU - Röder, Timo

AU - Rohde, Palle Duun

AU - Schwinn, Michael

AU - Clemmensen, Line Harder

AU - Didriksen, Maria

AU - Nyegaard, Mette

AU - Hjalgrim, Henrik

AU - Nielsen, Kaspar René

AU - Bruun, Mie Topholm

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

AU - Mikkelsen, Susan

AU - Sørensen, Erik

AU - Pedersen, Ole Birger Vestager

AU - Brunak, Søren

AU - Banasik, Karina

AU - Giordano, Giuseppe Nicola

AU - DBDS Genomic Consortium

PY - 2024

Y1 - 2024

N2 - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

AB - Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.

KW - Humans

KW - Genome-Wide Association Study

KW - Blood Donors

KW - Trust

KW - Phenotype

KW - Denmark

KW - Polymorphism, Single Nucleotide

KW - Genetic Predisposition to Disease

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DO - 10.1038/s41598-024-51636-0

M3 - Journal article

C2 - 38228779

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JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 1402

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