A genome-wide association study of social trust in 33,882 Danish blood donors

Celia Burgos Sequeros, Thomas Folkmann Hansen, David Westergaard, Ioannis Louloudis, Sebastian Kalamajski, Timo Röder, Palle Duun Rohde, Michael Schwinn, Line Harder Clemmensen, Maria Didriksen, Mette Nyegaard, Henrik Hjalgrim, Kaspar René Nielsen, Mie Topholm Bruun, Sisse Rye Ostrowski, Christian Erikstrup, Susan Mikkelsen, Erik Sørensen, Ole Birger Vestager Pedersen, Søren BrunakKarina Banasik, Giuseppe Nicola Giordano, DBDS Genomic Consortium

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Abstract

Social trust is a heritable trait that has been linked with physical health and longevity. In this study,
we performed genome‑wide association studies of self‑reported social trust in n = 33,882 Danish
blood donors. We observed genome‑wide and local evidence of genetic similarity with other brain‑
related phenotypes and estimated the single nucleotide polymorphism‑based heritability of trust to
be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one
significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a
gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in
an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta‑
analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer
region. Overall, our work confirms that social trust is heritable, and provides an initial look into the
genetic factors that influence it
OriginalsprogEngelsk
Artikelnummer1402
TidsskriftScientific Reports
Vol/bind14
Antal sider12
ISSN2045-2322
DOI
StatusUdgivet - 2024

Bibliografisk note

© 2024. The Author(s).

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