Abstract
In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Forensic science international. Genetics |
| Vol/bind | 12 |
| Sider (fra-til) | 12-23 |
| Antal sider | 12 |
| DOI | |
| Status | Udgivet - sep. 2014 |
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A global analysis of Y-chromosomal haplotype diversity for 23 STR loci. / Purps, Josephine; Siegert, Sabine; Willuweit, Sascha; Nagy, Marion; Alves, Cíntia; Salazar, Renato; Angustia, Sheila M T; Santos, Lorna H; Anslinger, Katja; Bayer, Birgit; Ayub, Qasim; Wei, Wei; Xue, Yali; Tyler-Smith, Chris; Bafalluy, Miriam Baeta; Martínez-Jarreta, Begoña; Egyed, Balazs; Balitzki, Beate; Tschumi, Sibylle; Ballard, David; Court, Denise Syndercombe; Barrantes, Xinia; Bäßler, Gerhard; Wiest, Tina; Berger, Burkhard; Niederstätter, Harald; Parson, Walther; Davis, Carey; Budowle, Bruce; Burri, Helen; Borer, Urs; Koller, Christoph; Carvalho, Elizeu F; Domingues, Patricia M; Chamoun, Wafaa Takash; Coble, Michael D; Hill, Carolyn R; Corach, Daniel; Caputo, Mariela; D'Amato, Maria E; Davison, Sean; Decorte, Ronny; Larmuseau, Maarten H D; Ottoni, Claudio; Rickards, Olga; Lu, Di; Jiang, Chengtao; Dobosz, Tadeusz; Jonkisz, Anna; Frank, William E; Furac, Ivana; Gehrig, Christian; Castella, Vincent; Grskovic, Branka; Haas, Cordula; Wobst, Jana; Hadzic, Gavrilo; Drobnic, Katja; Honda, Katsuya; Hou, Yiping; Zhou, Di; Li, Yan; Hu, Shengping; Chen, Shenglan; Immel, Uta-Dorothee; Lessig, Rüdiger; Jakovski, Zlatko; Ilievska, Tanja; Klann, Anja E; García, Cristina Cano; de Knijff, Peter; Kraaijenbrink, Thirsa; Kondili, Aikaterini; Miniati, Penelope; Vouropoulou, Maria; Kovacevic, Lejla; Marjanovic, Damir; Lindner, Iris; Mansour, Issam; Al-Azem, Mouayyad; Andari, Ansar El; Marino, Miguel; Furfuro, Sandra; Locarno, Laura; Martín, Pablo; Luque, Gracia M; Alonso, Antonio; Miranda, Luís Souto; Moreira, Helena; Mizuno, Natsuko; Iwashima, Yasuki; Neto, Rodrigo S Moura; Nogueira, Tatiana L S; Silva, Rosane; Nastainczyk-Wulf, Marina; Edelmann, Jeanett; Kohl, Michael; Nie, Shengjie; Wang, Xianping; Cheng, Baowen; Núñez, Carolina; Pancorbo, Marian Martínez de; Olofsson, Jill Katharina; Morling, Niels; Onofri, Valerio; Tagliabracci, Adriano; Pamjav, Horolma; Volgyi, Antonia; Barany, Gusztav; Pawlowski, Ryszard; Maciejewska, Agnieszka; Pelotti, Susi; Pepinski, Witold; Abreu-Glowacka, Monica; Phillips, Christopher; Cárdenas, Jorge; Rey-Gonzalez, Danel; Salas, Antonio; Brisighelli, Francesca; Capelli, Cristian; Toscanini, Ulises; Piccinini, Andrea; Piglionica, Marilidia; Baldassarra, Stefania L; Ploski, Rafal; Konarzewska, Magdalena; Jastrzebska, Emila; Robino, Carlo; Sajantila, Antti; Palo, Jukka U; Guevara, Evelyn; Salvador, Jazelyn; Ungria, Maria Corazon De; Rodriguez, Jae Joseph Russell; Schmidt, Ulrike; Schlauderer, Nicola; Saukko, Pekka; Schneider, Peter M; Sirker, Miriam; Shin, Kyoung-Jin; Oh, Yu Na; Skitsa, Iulia; Ampati, Alexandra; Smith, Tobi-Gail; Calvit, Lina Solis de; Stenzl, Vlastimil; Capal, Thomas; Tillmar, Andreas; Nilsson, Helena; Turrina, Stefania; De Leo, Domenico; Verzeletti, Andrea; Cortellini, Venusia; Wetton, Jon H; Gwynne, Gareth M; Jobling, Mark A; Whittle, Martin R; Sumita, Denilce R; Wolańska-Nowak, Paulina; Yong, Rita Y Y; Krawczak, Michael; Nothnagel, Michael; Roewer, Lutz.
I: Forensic science international. Genetics, Bind 12, 09.2014, s. 12-23.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - A global analysis of Y-chromosomal haplotype diversity for 23 STR loci
AU - Purps, Josephine
AU - Siegert, Sabine
AU - Willuweit, Sascha
AU - Nagy, Marion
AU - Alves, Cíntia
AU - Salazar, Renato
AU - Angustia, Sheila M T
AU - Santos, Lorna H
AU - Anslinger, Katja
AU - Bayer, Birgit
AU - Ayub, Qasim
AU - Wei, Wei
AU - Xue, Yali
AU - Tyler-Smith, Chris
AU - Bafalluy, Miriam Baeta
AU - Martínez-Jarreta, Begoña
AU - Egyed, Balazs
AU - Balitzki, Beate
AU - Tschumi, Sibylle
AU - Ballard, David
AU - Court, Denise Syndercombe
AU - Barrantes, Xinia
AU - Bäßler, Gerhard
AU - Wiest, Tina
AU - Berger, Burkhard
AU - Niederstätter, Harald
AU - Parson, Walther
AU - Davis, Carey
AU - Budowle, Bruce
AU - Burri, Helen
AU - Borer, Urs
AU - Koller, Christoph
AU - Carvalho, Elizeu F
AU - Domingues, Patricia M
AU - Chamoun, Wafaa Takash
AU - Coble, Michael D
AU - Hill, Carolyn R
AU - Corach, Daniel
AU - Caputo, Mariela
AU - D'Amato, Maria E
AU - Davison, Sean
AU - Decorte, Ronny
AU - Larmuseau, Maarten H D
AU - Ottoni, Claudio
AU - Rickards, Olga
AU - Lu, Di
AU - Jiang, Chengtao
AU - Dobosz, Tadeusz
AU - Jonkisz, Anna
AU - Frank, William E
AU - Furac, Ivana
AU - Gehrig, Christian
AU - Castella, Vincent
AU - Grskovic, Branka
AU - Haas, Cordula
AU - Wobst, Jana
AU - Hadzic, Gavrilo
AU - Drobnic, Katja
AU - Honda, Katsuya
AU - Hou, Yiping
AU - Zhou, Di
AU - Li, Yan
AU - Hu, Shengping
AU - Chen, Shenglan
AU - Immel, Uta-Dorothee
AU - Lessig, Rüdiger
AU - Jakovski, Zlatko
AU - Ilievska, Tanja
AU - Klann, Anja E
AU - García, Cristina Cano
AU - de Knijff, Peter
AU - Kraaijenbrink, Thirsa
AU - Kondili, Aikaterini
AU - Miniati, Penelope
AU - Vouropoulou, Maria
AU - Kovacevic, Lejla
AU - Marjanovic, Damir
AU - Lindner, Iris
AU - Mansour, Issam
AU - Al-Azem, Mouayyad
AU - Andari, Ansar El
AU - Marino, Miguel
AU - Furfuro, Sandra
AU - Locarno, Laura
AU - Martín, Pablo
AU - Luque, Gracia M
AU - Alonso, Antonio
AU - Miranda, Luís Souto
AU - Moreira, Helena
AU - Mizuno, Natsuko
AU - Iwashima, Yasuki
AU - Neto, Rodrigo S Moura
AU - Nogueira, Tatiana L S
AU - Silva, Rosane
AU - Nastainczyk-Wulf, Marina
AU - Edelmann, Jeanett
AU - Kohl, Michael
AU - Nie, Shengjie
AU - Wang, Xianping
AU - Cheng, Baowen
AU - Núñez, Carolina
AU - Pancorbo, Marian Martínez de
AU - Olofsson, Jill Katharina
AU - Morling, Niels
AU - Onofri, Valerio
AU - Tagliabracci, Adriano
AU - Pamjav, Horolma
AU - Volgyi, Antonia
AU - Barany, Gusztav
AU - Pawlowski, Ryszard
AU - Maciejewska, Agnieszka
AU - Pelotti, Susi
AU - Pepinski, Witold
AU - Abreu-Glowacka, Monica
AU - Phillips, Christopher
AU - Cárdenas, Jorge
AU - Rey-Gonzalez, Danel
AU - Salas, Antonio
AU - Brisighelli, Francesca
AU - Capelli, Cristian
AU - Toscanini, Ulises
AU - Piccinini, Andrea
AU - Piglionica, Marilidia
AU - Baldassarra, Stefania L
AU - Ploski, Rafal
AU - Konarzewska, Magdalena
AU - Jastrzebska, Emila
AU - Robino, Carlo
AU - Sajantila, Antti
AU - Palo, Jukka U
AU - Guevara, Evelyn
AU - Salvador, Jazelyn
AU - Ungria, Maria Corazon De
AU - Rodriguez, Jae Joseph Russell
AU - Schmidt, Ulrike
AU - Schlauderer, Nicola
AU - Saukko, Pekka
AU - Schneider, Peter M
AU - Sirker, Miriam
AU - Shin, Kyoung-Jin
AU - Oh, Yu Na
AU - Skitsa, Iulia
AU - Ampati, Alexandra
AU - Smith, Tobi-Gail
AU - Calvit, Lina Solis de
AU - Stenzl, Vlastimil
AU - Capal, Thomas
AU - Tillmar, Andreas
AU - Nilsson, Helena
AU - Turrina, Stefania
AU - De Leo, Domenico
AU - Verzeletti, Andrea
AU - Cortellini, Venusia
AU - Wetton, Jon H
AU - Gwynne, Gareth M
AU - Jobling, Mark A
AU - Whittle, Martin R
AU - Sumita, Denilce R
AU - Wolańska-Nowak, Paulina
AU - Yong, Rita Y Y
AU - Krawczak, Michael
AU - Nothnagel, Michael
AU - Roewer, Lutz
N1 - Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
PY - 2014/9
Y1 - 2014/9
N2 - In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.
AB - In a worldwide collaborative effort, 19,630 Y-chromosomes were sampled from 129 different populations in 51 countries. These chromosomes were typed for 23 short-tandem repeat (STR) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385ab, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, GATAH4, DYS481, DYS533, DYS549, DYS570, DYS576, and DYS643) and using the PowerPlex Y23 System (PPY23, Promega Corporation, Madison, WI). Locus-specific allelic spectra of these markers were determined and a consistently high level of allelic diversity was observed. A considerable number of null, duplicate and off-ladder alleles were revealed. Standard single-locus and haplotype-based parameters were calculated and compared between subsets of Y-STR markers established for forensic casework. The PPY23 marker set provides substantially stronger discriminatory power than other available kits but at the same time reveals the same general patterns of population structure as other marker sets. A strong correlation was observed between the number of Y-STRs included in a marker set and some of the forensic parameters under study. Interestingly a weak but consistent trend toward smaller genetic distances resulting from larger numbers of markers became apparent.
U2 - 10.1016/j.fsigen.2014.04.008
DO - 10.1016/j.fsigen.2014.04.008
M3 - Journal article
C2 - 24854874
VL - 12
SP - 12
EP - 23
JO - Forensic Science International: Genetics
JF - Forensic Science International: Genetics
SN - 1872-4973
ER -