A model of physical factors in the structural adaptation of microvascular networks in normotension and hypertension.

Jens Christian Brings Jacobsen; Finn Gustafsson; N.-H. Holstein-Rathlou

A model of physical factors in the structural adaptation of microvascular networks in normotension and hypertension.

Jens Christian Brings Jacobsen, Finn Gustafsson, N.-H. Holstein-Rathlou

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

23 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Nov

Originalsprog	Engelsk
Tidsskrift	Physiological Measurement
Vol/bind	24
Udgave nummer	4
Sider (fra-til)	891-912
Antal sider	21
ISSN	0967-3334
Status	Udgivet - 2003

Bibliografisk note

Keywords: Adaptation, Physiological; Algorithms; Biomechanics; Capillaries; Computer Simulation; Endothelium, Vascular; Hemodynamics; Humans; Hypertension; Microcirculation; Models, Biological; Perfusion

Citationsformater

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title = "A model of physical factors in the structural adaptation of microvascular networks in normotension and hypertension.",

abstract = "Adequate function of the microcirculation is vital to any tissue. To maintain an optimal function, microvascular networks must be able to adapt structurally to changes in the physical environment. Here we present a mathematical network model based on vessel wall mechanics. We assume based on experimental observations that longstanding change in transmural pressure elicits a change in the vascular wall-to-lumen ratio for maintaining circumferential wall stress at a certain level. In addition, experimental observations show that chronic change in fluid shear stress at the vascular wall elicits a persistent change in luminal diameter. On this basis we hypothesize that wall influencing substances released from the endothelium in response to shear stress have a certain optimal level in the vascular wall. Deviation from this level will cause vascular remodeling, i.e. a structural change in luminal diameter, until equilibrium is restored. The model explains several of the key features observed experimentally in the microcirculation in normotension and hypertension. Most importantly, it suggests a scenario where overall network structure and network hemodynamics depend on adaptation to local hemodynamic stimuli in the individual vessel. Simulated results show emanating microvascular networks with properties similar to those observed in vivo. The model points to an altered endothelial function as a key factor in the development of vascular changes characteristic of hypertension.",

author = "Jacobsen, {Jens Christian Brings} and Finn Gustafsson and N.-H. Holstein-Rathlou",

note = "Keywords: Adaptation, Physiological; Algorithms; Biomechanics; Capillaries; Computer Simulation; Endothelium, Vascular; Hemodynamics; Humans; Hypertension; Microcirculation; Models, Biological; Perfusion",

year = "2003",

language = "English",

volume = "24",

pages = "891--912",

journal = "Physiological Measurement",

issn = "0967-3334",

publisher = "Institute of Physics Publishing Ltd",

number = "4",

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TY - JOUR

T1 - A model of physical factors in the structural adaptation of microvascular networks in normotension and hypertension.

AU - Jacobsen, Jens Christian Brings

AU - Gustafsson, Finn

AU - Holstein-Rathlou, N.-H.

N1 - Keywords: Adaptation, Physiological; Algorithms; Biomechanics; Capillaries; Computer Simulation; Endothelium, Vascular; Hemodynamics; Humans; Hypertension; Microcirculation; Models, Biological; Perfusion

PY - 2003

Y1 - 2003

N2 - Adequate function of the microcirculation is vital to any tissue. To maintain an optimal function, microvascular networks must be able to adapt structurally to changes in the physical environment. Here we present a mathematical network model based on vessel wall mechanics. We assume based on experimental observations that longstanding change in transmural pressure elicits a change in the vascular wall-to-lumen ratio for maintaining circumferential wall stress at a certain level. In addition, experimental observations show that chronic change in fluid shear stress at the vascular wall elicits a persistent change in luminal diameter. On this basis we hypothesize that wall influencing substances released from the endothelium in response to shear stress have a certain optimal level in the vascular wall. Deviation from this level will cause vascular remodeling, i.e. a structural change in luminal diameter, until equilibrium is restored. The model explains several of the key features observed experimentally in the microcirculation in normotension and hypertension. Most importantly, it suggests a scenario where overall network structure and network hemodynamics depend on adaptation to local hemodynamic stimuli in the individual vessel. Simulated results show emanating microvascular networks with properties similar to those observed in vivo. The model points to an altered endothelial function as a key factor in the development of vascular changes characteristic of hypertension.

AB - Adequate function of the microcirculation is vital to any tissue. To maintain an optimal function, microvascular networks must be able to adapt structurally to changes in the physical environment. Here we present a mathematical network model based on vessel wall mechanics. We assume based on experimental observations that longstanding change in transmural pressure elicits a change in the vascular wall-to-lumen ratio for maintaining circumferential wall stress at a certain level. In addition, experimental observations show that chronic change in fluid shear stress at the vascular wall elicits a persistent change in luminal diameter. On this basis we hypothesize that wall influencing substances released from the endothelium in response to shear stress have a certain optimal level in the vascular wall. Deviation from this level will cause vascular remodeling, i.e. a structural change in luminal diameter, until equilibrium is restored. The model explains several of the key features observed experimentally in the microcirculation in normotension and hypertension. Most importantly, it suggests a scenario where overall network structure and network hemodynamics depend on adaptation to local hemodynamic stimuli in the individual vessel. Simulated results show emanating microvascular networks with properties similar to those observed in vivo. The model points to an altered endothelial function as a key factor in the development of vascular changes characteristic of hypertension.

M3 - Journal article

C2 - 14658781

VL - 24

SP - 891

EP - 912

JO - Physiological Measurement

JF - Physiological Measurement

SN - 0967-3334

IS - 4

ER -