A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides

Carsten Behrens; Kenneth H. Petersen; Michael Egholm; John Nielsen; Ole Buchard; Otto Dahl

doi:10.1016/0960-894X(95)00315-K

A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides

Carsten Behrens^*, Kenneth H. Petersen, Michael Egholm, John Nielsen, Ole Buchard, Otto Dahl

^*Corresponding author af dette arbejde

LUKKET: Natural Products and Peptides

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

7 Citationer (Scopus)

Abstract

The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.

Originalsprog	Engelsk
Tidsskrift	Bioorganic & Medicinal Chemistry Letters
Vol/bind	5
Udgave nummer	16
Sider (fra-til)	1785-1790
Antal sider	6
ISSN	0960-894X
DOI	https://doi.org/10.1016/0960-894X(95)00315-K
Status	Udgivet - 17 aug. 1995

Adgang til dokumentet

10.1016/0960-894X(95)00315-K

http://www.scopus.com/inward/record.url?scp=0029155594&partnerID=8YFLogxK

Citationsformater

@article{8770dcc074cd11dbbee902004c4f4f50,

title = "A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides",

abstract = "The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.",

author = "Carsten Behrens and Petersen, {Kenneth H.} and Michael Egholm and John Nielsen and Ole Buchard and Otto Dahl",

year = "1995",

month = aug,

day = "17",

doi = "10.1016/0960-894X(95)00315-K",

language = "English",

volume = "5",

pages = "1785--1790",

journal = "Bioorganic & Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Pergamon Press",

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}

TY - JOUR

T1 - A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides

AU - Behrens, Carsten

AU - Petersen, Kenneth H.

AU - Egholm, Michael

AU - Nielsen, John

AU - Buchard, Ole

AU - Dahl, Otto

PY - 1995/8/17

Y1 - 1995/8/17

N2 - The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.

AB - The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.

U2 - 10.1016/0960-894X(95)00315-K

DO - 10.1016/0960-894X(95)00315-K

M3 - Journal article

AN - SCOPUS:0029155594

VL - 5

SP - 1785

EP - 1790

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 16

ER -