A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca)

Jens Mayer; Kyriakos Tsangaras; Felix Heeger; Maria del Carmen Avila Arcos; Mark D. Stenglein; Wei Chen; Wei Sun; Camila J. Mazzoni; Nikolaus Osterrieder; Alex D. Greenwood

doi:10.1016/j.virol.2013.05.008

A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca)

Jens Mayer, Kyriakos Tsangaras, Felix Heeger, Maria del Carmen Avila Arcos, Mark D. Stenglein, Wei Chen, Wei Sun, Camila J. Mazzoni, Nikolaus Osterrieder, Alex D. Greenwood

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Transcriptome analysis of polar bears (Ursus maritimus) yielded sequences with highest similarity to the human endogenous retrovirus group HERV-K(HML-2). Further analysis of the polar bear draft genome identified an endogenous betaretrovirus group comprising 26 proviral copies and 231 solo LTRs. Molecular dating indicates the group originated before the divergence of bears from a common ancestor but is not present in all carnivores. Closely related sequences were identified in the giant panda (Ailuropoda melanoleuca) and characterized from its genome. We have designated the polar bear and giant panda sequences U. maritimus endogenous retrovirus (UmaERV) and A. melanoleuca endogenous retrovirus (AmeERV), respectively. Phylogenetic analysis demonstrated that the bear virus group is nested within the HERV-K supergroup among bovine and bat endogenous retroviruses suggesting a complex evolutionary history within the HERV-K group. All individual remnants of proviral sequences contain numerous frameshifts and stop codons and thus, the virus is likely non-infectious.

Originalsprog	Engelsk
Tidsskrift	Virology
Vol/bind	443
Udgave nummer	1
Sider (fra-til)	1-10
Antal sider	10
ISSN	0042-6822
DOI	https://doi.org/10.1016/j.virol.2013.05.008
Status	Udgivet - 15 aug. 2013

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@article{179ed642512c4c56870e6c5b20cc52a9,

title = "A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca)",

abstract = "Transcriptome analysis of polar bears (Ursus maritimus) yielded sequences with highest similarity to the human endogenous retrovirus group HERV-K(HML-2). Further analysis of the polar bear draft genome identified an endogenous betaretrovirus group comprising 26 proviral copies and 231 solo LTRs. Molecular dating indicates the group originated before the divergence of bears from a common ancestor but is not present in all carnivores. Closely related sequences were identified in the giant panda (Ailuropoda melanoleuca) and characterized from its genome. We have designated the polar bear and giant panda sequences U. maritimus endogenous retrovirus (UmaERV) and A. melanoleuca endogenous retrovirus (AmeERV), respectively. Phylogenetic analysis demonstrated that the bear virus group is nested within the HERV-K supergroup among bovine and bat endogenous retroviruses suggesting a complex evolutionary history within the HERV-K group. All individual remnants of proviral sequences contain numerous frameshifts and stop codons and thus, the virus is likely non-infectious.",

author = "Jens Mayer and Kyriakos Tsangaras and Felix Heeger and {Avila Arcos}, {Maria del Carmen} and Stenglein, {Mark D.} and Wei Chen and Wei Sun and Mazzoni, {Camila J.} and Nikolaus Osterrieder and Greenwood, {Alex D.}",

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doi = "10.1016/j.virol.2013.05.008",

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T1 - A novel endogenous betaretrovirus group characterized from polar bears (Ursus maritimus) and giant pandas (Ailuropoda melanoleuca)

AU - Mayer, Jens

AU - Tsangaras, Kyriakos

AU - Heeger, Felix

AU - Avila Arcos, Maria del Carmen

AU - Stenglein, Mark D.

AU - Chen, Wei

AU - Sun, Wei

AU - Mazzoni, Camila J.

AU - Osterrieder, Nikolaus

AU - Greenwood, Alex D.

PY - 2013/8/15

Y1 - 2013/8/15

N2 - Transcriptome analysis of polar bears (Ursus maritimus) yielded sequences with highest similarity to the human endogenous retrovirus group HERV-K(HML-2). Further analysis of the polar bear draft genome identified an endogenous betaretrovirus group comprising 26 proviral copies and 231 solo LTRs. Molecular dating indicates the group originated before the divergence of bears from a common ancestor but is not present in all carnivores. Closely related sequences were identified in the giant panda (Ailuropoda melanoleuca) and characterized from its genome. We have designated the polar bear and giant panda sequences U. maritimus endogenous retrovirus (UmaERV) and A. melanoleuca endogenous retrovirus (AmeERV), respectively. Phylogenetic analysis demonstrated that the bear virus group is nested within the HERV-K supergroup among bovine and bat endogenous retroviruses suggesting a complex evolutionary history within the HERV-K group. All individual remnants of proviral sequences contain numerous frameshifts and stop codons and thus, the virus is likely non-infectious.

AB - Transcriptome analysis of polar bears (Ursus maritimus) yielded sequences with highest similarity to the human endogenous retrovirus group HERV-K(HML-2). Further analysis of the polar bear draft genome identified an endogenous betaretrovirus group comprising 26 proviral copies and 231 solo LTRs. Molecular dating indicates the group originated before the divergence of bears from a common ancestor but is not present in all carnivores. Closely related sequences were identified in the giant panda (Ailuropoda melanoleuca) and characterized from its genome. We have designated the polar bear and giant panda sequences U. maritimus endogenous retrovirus (UmaERV) and A. melanoleuca endogenous retrovirus (AmeERV), respectively. Phylogenetic analysis demonstrated that the bear virus group is nested within the HERV-K supergroup among bovine and bat endogenous retroviruses suggesting a complex evolutionary history within the HERV-K group. All individual remnants of proviral sequences contain numerous frameshifts and stop codons and thus, the virus is likely non-infectious.

U2 - 10.1016/j.virol.2013.05.008

DO - 10.1016/j.virol.2013.05.008

M3 - Journal article

C2 - 23725819

SN - 0042-6822

VL - 443

SP - 1

EP - 10

JO - Virology

JF - Virology

IS - 1

ER -