A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control

Tobias K.S. Ritschel; Asbjorn Thode Reenberg; Emilie B. Lindkvist; Christian Laugesen; Jannet Svensson; Ajenthen G. Ranjan; Kirsten Norgaard; Bernd Dammann; John Bagterp Jorgensen

doi:10.23919/ECC57647.2023.10178186

A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control

Tobias K.S. Ritschel, Asbjorn Thode Reenberg, Emilie B. Lindkvist, Christian Laugesen, Jannet Svensson, Ajenthen G. Ranjan, Kirsten Norgaard, Bernd Dammann, John Bagterp Jorgensen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › peer review

Abstract

We propose a model-free artificial pancreas (AP) for people with type 1 diabetes. The algorithmic parameters are tuned to a virtual population of 1,000,000 individuals, and the AP repeatedly estimates the basal and bolus insulin requirements necessary for maintaining normal blood glucose levels. Therefore, the AP can be used without healthcare personnel or engineers customizing the algorithm to each user. The estimates are based on bodyweight, measurements from a continuous glucose monitor (CGM), and estimates of the meal carbohydrate contents. In a virtual clinical trial with a111,000,000 individuals (i.e., a Monte Carlo closed-loop simulation), the AP achieves a mean time in range of more than 87% and over 88% of the participants satisfy several glycemic targets.

Originalsprog	Engelsk
Titel	2023 European Control Conference, ECC 2023
Antal sider	6
Forlag	Institute of Electrical and Electronics Engineers Inc.
Publikationsdato	2023
Udgave	1
ISBN (Elektronisk)	9783907144084
DOI	https://doi.org/10.23919/ECC57647.2023.10178186
Status	Udgivet - 2023
Udgivet eksternt	Ja
Begivenhed	2023 European Control Conference, ECC 2023 - Bucharest, Rumænien Varighed: 13 jun. 2023 → 16 jun. 2023

Konference

Konference	2023 European Control Conference, ECC 2023
Land/Område	Rumænien
By	Bucharest
Periode	13/06/2023 → 16/06/2023

Navn	2023 European Control Conference, ECC 2023

Bibliografisk note

Funding Information:
This work was partially funded by the IFD Grand Solution project ADAPT-T2D (9068-00056B). A. T. Reenberg, T. K. S. Ritschel, B. Dammann, and J. B. Jørgensen are with the Department of Applied Mathematics and Computer Science, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark. E. B. Lindkvist, C. Laugesen, J. Svensson, A. G. Ranjan, and K. Nørgaard are with Steno Diabetes Center Copenhagen, Clinical Research, DK-2730 Herlev, Denmark. Corresponding author: J. B. Jørgensen (E-mail: [email protected]).

Publisher Copyright:
© 2023 EUCA.

Adgang til dokumentet

10.23919/ECC57647.2023.10178186

Citationsformater

Ritschel, T. K. S., Reenberg, A. T., Lindkvist, E. B., Laugesen, C., Svensson, J., Ranjan, A. G., Norgaard, K., Dammann, B., & Jorgensen, J. B. (2023). A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control. I 2023 European Control Conference, ECC 2023 (1 udg.). Institute of Electrical and Electronics Engineers Inc.. 2023 European Control Conference, ECC 2023 https://doi.org/10.23919/ECC57647.2023.10178186

A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control. / Ritschel, Tobias K.S.; Reenberg, Asbjorn Thode; Lindkvist, Emilie B.; Laugesen, Christian; Svensson, Jannet; Ranjan, Ajenthen G.; Norgaard, Kirsten; Dammann, Bernd; Jorgensen, John Bagterp.

2023 European Control Conference, ECC 2023. 1. udg. Institute of Electrical and Electronics Engineers Inc., 2023. (2023 European Control Conference, ECC 2023).

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › peer review

Ritschel, TKS, Reenberg, AT, Lindkvist, EB, Laugesen, C, Svensson, J, Ranjan, AG, Norgaard, K, Dammann, B & Jorgensen, JB 2023, A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control. i 2023 European Control Conference, ECC 2023. 1 udg, Institute of Electrical and Electronics Engineers Inc., 2023 European Control Conference, ECC 2023, 2023 European Control Conference, ECC 2023, Bucharest, Rumænien, 13/06/2023. https://doi.org/10.23919/ECC57647.2023.10178186

Ritschel TKS, Reenberg AT, Lindkvist EB, Laugesen C, Svensson J, Ranjan AG et al. A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control. I 2023 European Control Conference, ECC 2023. 1 udg. Institute of Electrical and Electronics Engineers Inc. 2023. (2023 European Control Conference, ECC 2023). https://doi.org/10.23919/ECC57647.2023.10178186

Ritschel, Tobias K.S. ; Reenberg, Asbjorn Thode ; Lindkvist, Emilie B. ; Laugesen, Christian ; Svensson, Jannet ; Ranjan, Ajenthen G. ; Norgaard, Kirsten ; Dammann, Bernd ; Jorgensen, John Bagterp. / A one-size-fits-all artificial pancreas for people with type 1 diabetes based on physiological insight and feedback control. 2023 European Control Conference, ECC 2023. 1. udg. Institute of Electrical and Electronics Engineers Inc., 2023. (2023 European Control Conference, ECC 2023).

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