A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation

Ronny Clement Florent Kupers; Vibe G Frokjaer; Arne Naert; Rune Christensen; Esben Budtz-Joergensen; Henrik Kehlet; Gitte M Knudsen

doi:10.1016/j.neuroimage.2008.10.011

A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation

Ronny Clement Florent Kupers, Vibe G Frokjaer, Arne Naert, Rune Christensen, Esben Budtz-Joergensen, Henrik Kehlet, Gitte M Knudsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

39 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Feb

Originalsprog	Engelsk
Tidsskrift	NeuroImage
Vol/bind	44
Udgave nummer	3
Sider (fra-til)	1001-7
Antal sider	6
ISSN	1053-8119
DOI	https://doi.org/10.1016/j.neuroimage.2008.10.011
Status	Udgivet - 2009

Bibliografisk note

Keywords: Adult; Binding Sites; Brain; Female; Fluorine Radioisotopes; Hot Temperature; Humans; Ketanserin; Male; Pain; Pain Threshold; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Receptor, Serotonin, 5-HT2A; Tissue Distribution

Adgang til dokumentet

10.1016/j.neuroimage.2008.10.011

Citationsformater

A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation. / Kupers, Ronny Clement Florent; Frokjaer, Vibe G; Naert, Arne; Christensen, Rune; Budtz-Joergensen, Esben ; Kehlet, Henrik ; Knudsen, Gitte M.

I: NeuroImage, Bind 44, Nr. 3, 2009, s. 1001-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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title = "A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation",

abstract = "There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) to study the relationship between baseline 5-HT(2A) binding in the brain and responses to noxious heat stimulation in a group of young healthy volunteers. Twenty-one healthy subjects underwent PET scanning with the 5-HT(2A) antagonist, [(18)F]altanserin. In addition, participants underwent a battery of pain tests using noxious heat stimulation to assess pain threshold, pain tolerance and response to short-lasting phasic and long-lasting (7-minute) tonic painful stimulation. Significant positive correlations were found between tonic pain ratings and [(18)F]altanserin binding in orbitofrontal (r=0.66; p=0.005), medial inferior frontal (r=0.60; p=0.014), primary sensory-motor (r=0.61; p=0.012) and posterior cingulate (r=0.63; p=0.009) cortices. In contrast, measures of regional [(18)F]altanserin binding did not correlate with pain threshold, pain tolerance, or suprathreshold phasic pain responses. These data suggest that cortical 5-HT(2A) receptor availability co-varies with responses to tonic pain. The correlation between [(18)F]altanserin binding in prefrontal cortex and tonic pain suggests a possible role of this brain region in the modulation and/or cognitive-evaluative appreciation of pain.",

author = "Kupers, {Ronny Clement Florent} and Frokjaer, {Vibe G} and Arne Naert and Rune Christensen and Esben Budtz-Joergensen and Henrik Kehlet and Knudsen, {Gitte M}",

note = "Keywords: Adult; Binding Sites; Brain; Female; Fluorine Radioisotopes; Hot Temperature; Humans; Ketanserin; Male; Pain; Pain Threshold; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Receptor, Serotonin, 5-HT2A; Tissue Distribution",

year = "2009",

doi = "10.1016/j.neuroimage.2008.10.011",

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T1 - A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation

AU - Kupers, Ronny Clement Florent

AU - Frokjaer, Vibe G

AU - Naert, Arne

AU - Christensen, Rune

AU - Budtz-Joergensen, Esben

AU - Kehlet, Henrik

AU - Knudsen, Gitte M

N1 - Keywords: Adult; Binding Sites; Brain; Female; Fluorine Radioisotopes; Hot Temperature; Humans; Ketanserin; Male; Pain; Pain Threshold; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Receptor, Serotonin, 5-HT2A; Tissue Distribution

PY - 2009

Y1 - 2009

N2 - There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) to study the relationship between baseline 5-HT(2A) binding in the brain and responses to noxious heat stimulation in a group of young healthy volunteers. Twenty-one healthy subjects underwent PET scanning with the 5-HT(2A) antagonist, [(18)F]altanserin. In addition, participants underwent a battery of pain tests using noxious heat stimulation to assess pain threshold, pain tolerance and response to short-lasting phasic and long-lasting (7-minute) tonic painful stimulation. Significant positive correlations were found between tonic pain ratings and [(18)F]altanserin binding in orbitofrontal (r=0.66; p=0.005), medial inferior frontal (r=0.60; p=0.014), primary sensory-motor (r=0.61; p=0.012) and posterior cingulate (r=0.63; p=0.009) cortices. In contrast, measures of regional [(18)F]altanserin binding did not correlate with pain threshold, pain tolerance, or suprathreshold phasic pain responses. These data suggest that cortical 5-HT(2A) receptor availability co-varies with responses to tonic pain. The correlation between [(18)F]altanserin binding in prefrontal cortex and tonic pain suggests a possible role of this brain region in the modulation and/or cognitive-evaluative appreciation of pain.

AB - There is a large body of evidence that serotonin [5-hydroxytryptamine (5-HT)] plays an important role in the transmission and regulation of pain. Here we used positron emission tomography (PET) to study the relationship between baseline 5-HT(2A) binding in the brain and responses to noxious heat stimulation in a group of young healthy volunteers. Twenty-one healthy subjects underwent PET scanning with the 5-HT(2A) antagonist, [(18)F]altanserin. In addition, participants underwent a battery of pain tests using noxious heat stimulation to assess pain threshold, pain tolerance and response to short-lasting phasic and long-lasting (7-minute) tonic painful stimulation. Significant positive correlations were found between tonic pain ratings and [(18)F]altanserin binding in orbitofrontal (r=0.66; p=0.005), medial inferior frontal (r=0.60; p=0.014), primary sensory-motor (r=0.61; p=0.012) and posterior cingulate (r=0.63; p=0.009) cortices. In contrast, measures of regional [(18)F]altanserin binding did not correlate with pain threshold, pain tolerance, or suprathreshold phasic pain responses. These data suggest that cortical 5-HT(2A) receptor availability co-varies with responses to tonic pain. The correlation between [(18)F]altanserin binding in prefrontal cortex and tonic pain suggests a possible role of this brain region in the modulation and/or cognitive-evaluative appreciation of pain.

U2 - 10.1016/j.neuroimage.2008.10.011

DO - 10.1016/j.neuroimage.2008.10.011

M3 - Journal article

C2 - 19007894

VL - 44

SP - 1001

EP - 1007

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 3

ER -