A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)

S Djurovic; A K Kähler; B Kulle; E G Jönsson; I Agartz; S Le Hellard; H Hall; K D Jakobsen; T Hansen; I Melle; T Werge; V M Steen; O A Andreassen; S Djurovic; A K Kähler; B Kulle; E G Jönsson; I Agartz; S Le Hellard; H Hall; Klaus Damgaard Jakobsen; Thomas Folkmann Hansen; I Melle; T Werge; V M Steen; O A Andreassen

doi:10.1016/j.schres.2008.10.010

A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)

S Djurovic, A K Kähler, B Kulle, E G Jönsson, I Agartz, S Le Hellard, H Hall, K D Jakobsen, T Hansen, I Melle, T Werge, V M Steen, O A Andreassen, S Djurovic, A K Kähler, B Kulle, E G Jönsson, I Agartz, S Le Hellard, H HallKlaus Damgaard Jakobsen, Thomas Folkmann Hansen, I Melle, T Werge, V M Steen, O A Andreassen

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Feb

Originalsprog	Engelsk
Tidsskrift	Schizophrenia Research
Vol/bind	107
Udgave nummer	2-3
Sider (fra-til)	242-8
Antal sider	6
ISSN	0920-9964
DOI	https://doi.org/10.1016/j.schres.2008.10.010 https://doi.org/10.1016/j.schres.2008.10.010
Status	Udgivet - 2009

Bibliografisk note

Keywords: Adult; Alleles; Chromosomes, Human, Pair 1; Female; Genetic Markers; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Psychotic Disorders; Receptors, Kainic Acid; Scandinavia; Schizophrenia; Schizophrenic Psychology

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Citationsformater

Djurovic, S., Kähler, A. K., Kulle, B., Jönsson, E. G., Agartz, I., Le Hellard, S., Hall, H., Jakobsen, K. D., Hansen, T., Melle, I., Werge, T., Steen, V. M., Andreassen, O. A., Djurovic, S., Kähler, A. K., Kulle, B., Jönsson, E. G., Agartz, I., Le Hellard, S., ... Andreassen, O. A. (2009). A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE). Schizophrenia Research, 107(2-3), 242-8. https://doi.org/10.1016/j.schres.2008.10.010, https://doi.org/10.1016/j.schres.2008.10.010

Djurovic, S, Kähler, AK, Kulle, B, Jönsson, EG, Agartz, I, Le Hellard, S, Hall, H, Jakobsen, KD, Hansen, T, Melle, I, Werge, T, Steen, VM, Andreassen, OA, Djurovic, S, Kähler, AK, Kulle, B, Jönsson, EG, Agartz, I, Le Hellard, S, Hall, H, Jakobsen, KD, Hansen, TF, Melle, I, Werge, T, Steen, VM & Andreassen, OA 2009, 'A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)', Schizophrenia Research, bind 107, nr. 2-3, s. 242-8. https://doi.org/10.1016/j.schres.2008.10.010, https://doi.org/10.1016/j.schres.2008.10.010

@article{f0914a50a5ed11df928f000ea68e967b,

title = "A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)",

abstract = "There is considerable evidence of altered glutamatergic signalling in schizophrenia and a polymorphic variant of the GRIK3 glutamate receptor gene on 1p34-33 has previously been associated to this psychotic disorder. We therefore conducted a systematic association study with 30 HapMap-selected tagging SNPs across GRIK3 in three independent samples of Scandinavian origin from the Scandinavian Collaboration of Psychiatric Etiology (SCOPE), including a total of 839 cases with schizophrenia spectrum and 1473 healthy controls. Four markers (rs6671364, rs17461259, rs472188, and rs535620) attained nominally significant P-values in both the genotypic (0.002, 0.02, 0.03, and 0.05, respectively) and allelic (0.001, 0.006, 0.03, and 0.02, respectively) association tests for the combined sample, and 2 additional markers (rs481047and rs1160751) displayed significance for the genotype (P-values: 0.03 and 0.04). Several haplotypes, that all included at least one of the four SNPs implicated by the single marker analysis, remained significant after adjustment for multiple testing using permutations with 10,000 shuffles. In addition we observed an association for two of the four significant GRIK3 markers (rs472188 and rs535620) to scores for negative symptoms on the PANSS scale. The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia.",

author = "S Djurovic and K{\"a}hler, {A K} and B Kulle and J{\"o}nsson, {E G} and I Agartz and {Le Hellard}, S and H Hall and Jakobsen, {K D} and T Hansen and I Melle and T Werge and Steen, {V M} and Andreassen, {O A} and S Djurovic and K{\"a}hler, {A K} and B Kulle and J{\"o}nsson, {E G} and I Agartz and {Le Hellard}, S and H Hall and Jakobsen, {Klaus Damgaard} and Hansen, {Thomas Folkmann} and I Melle and T Werge and Steen, {V M} and Andreassen, {O A}",

note = "Keywords: Adult; Alleles; Chromosomes, Human, Pair 1; Female; Genetic Markers; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Psychotic Disorders; Receptors, Kainic Acid; Scandinavia; Schizophrenia; Schizophrenic Psychology",

year = "2009",

doi = "10.1016/j.schres.2008.10.010",

language = "English",

volume = "107",

pages = "242--8",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier",

number = "2-3",

}

TY - JOUR

T1 - A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE)

AU - Djurovic, S

AU - Kähler, A K

AU - Kulle, B

AU - Jönsson, E G

AU - Agartz, I

AU - Le Hellard, S

AU - Hall, H

AU - Jakobsen, K D

AU - Hansen, T

AU - Melle, I

AU - Werge, T

AU - Steen, V M

AU - Andreassen, O A

AU - Djurovic, S

AU - Kähler, A K

AU - Kulle, B

AU - Jönsson, E G

AU - Agartz, I

AU - Le Hellard, S

AU - Hall, H

AU - Jakobsen, Klaus Damgaard

AU - Hansen, Thomas Folkmann

AU - Melle, I

AU - Werge, T

AU - Steen, V M

AU - Andreassen, O A

N1 - Keywords: Adult; Alleles; Chromosomes, Human, Pair 1; Female; Genetic Markers; Genotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Psychotic Disorders; Receptors, Kainic Acid; Scandinavia; Schizophrenia; Schizophrenic Psychology

PY - 2009

Y1 - 2009

N2 - There is considerable evidence of altered glutamatergic signalling in schizophrenia and a polymorphic variant of the GRIK3 glutamate receptor gene on 1p34-33 has previously been associated to this psychotic disorder. We therefore conducted a systematic association study with 30 HapMap-selected tagging SNPs across GRIK3 in three independent samples of Scandinavian origin from the Scandinavian Collaboration of Psychiatric Etiology (SCOPE), including a total of 839 cases with schizophrenia spectrum and 1473 healthy controls. Four markers (rs6671364, rs17461259, rs472188, and rs535620) attained nominally significant P-values in both the genotypic (0.002, 0.02, 0.03, and 0.05, respectively) and allelic (0.001, 0.006, 0.03, and 0.02, respectively) association tests for the combined sample, and 2 additional markers (rs481047and rs1160751) displayed significance for the genotype (P-values: 0.03 and 0.04). Several haplotypes, that all included at least one of the four SNPs implicated by the single marker analysis, remained significant after adjustment for multiple testing using permutations with 10,000 shuffles. In addition we observed an association for two of the four significant GRIK3 markers (rs472188 and rs535620) to scores for negative symptoms on the PANSS scale. The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia.

AB - There is considerable evidence of altered glutamatergic signalling in schizophrenia and a polymorphic variant of the GRIK3 glutamate receptor gene on 1p34-33 has previously been associated to this psychotic disorder. We therefore conducted a systematic association study with 30 HapMap-selected tagging SNPs across GRIK3 in three independent samples of Scandinavian origin from the Scandinavian Collaboration of Psychiatric Etiology (SCOPE), including a total of 839 cases with schizophrenia spectrum and 1473 healthy controls. Four markers (rs6671364, rs17461259, rs472188, and rs535620) attained nominally significant P-values in both the genotypic (0.002, 0.02, 0.03, and 0.05, respectively) and allelic (0.001, 0.006, 0.03, and 0.02, respectively) association tests for the combined sample, and 2 additional markers (rs481047and rs1160751) displayed significance for the genotype (P-values: 0.03 and 0.04). Several haplotypes, that all included at least one of the four SNPs implicated by the single marker analysis, remained significant after adjustment for multiple testing using permutations with 10,000 shuffles. In addition we observed an association for two of the four significant GRIK3 markers (rs472188 and rs535620) to scores for negative symptoms on the PANSS scale. The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia.

U2 - 10.1016/j.schres.2008.10.010

DO - 10.1016/j.schres.2008.10.010

M3 - Journal article

C2 - 19022628

SN - 0920-9964

VL - 107

SP - 242

EP - 248

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -