A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

Masoud Behravesh; Juan Fernandez-Tajes; Angela C. Estampador; Tibor V. Varga; Ómar S. Gunnarsson; Helena Strevens; Simon Timpka; Paul W. Franks

doi:10.1038/s41598-021-03257-0

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy

Masoud Behravesh, Juan Fernandez-Tajes, Angela C. Estampador, Tibor V. Varga, Ómar S. Gunnarsson, Helena Strevens, Simon Timpka, Paul W. Franks^*

^*Corresponding author af dette arbejde

Afdeling for Epidemiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

Both disturbed sleep and lack of exercise can disrupt metabolism in pregnancy. Accelerometery was used to objectively assess movement during waking (physical activity) and movement during sleeping (sleep disturbance) periods and evaluated relationships with continuous blood glucose variation during pregnancy. Data was analysed prospectively. 15-women without pre-existing diabetes mellitus wore continuous glucose monitors and triaxial accelerometers from February through June 2018 in Sweden. The relationships between physical activity and sleep disturbance with blood glucose rate of change were assessed. An interaction term was fitted to determine difference in the relationship between movement and glucose variation, conditional on waking/sleeping. Total movement was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.037, − 0.026)). Stratified analyses showed total physical activity was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.040, − 0.028)), whereas sleep disturbance was not related to glucose rate of change (p = 0.07, 95% CI (< − 0.001, 0.013)). The interaction term was positively related to glucose rate of change (p < 0.001, 95% CI (0.029, 0.047)). This study provides temporal evidence of a relationship between total movement and glycemic control in pregnancy, which is conditional on time of day. Movement is beneficially related with glycemic control while awake, but not during sleep.

Originalsprog	Engelsk
Artikelnummer	23911
Tidsskrift	Scientific Reports
Vol/bind	11
Udgave nummer	1
ISSN	2045-2322
DOI	https://doi.org/10.1038/s41598-021-03257-0
Status	Udgivet - 2021

Bibliografisk note

Funding Information:
Open access funding provided by Lund University. The study was supported by grants from the Novo Nordisk Foundation (https://novonordiskfonden.dk/en/) via NNF16OC0021020, European Foundation for the Study of Diabetes, and the Swedish Heart Lung Foundation (2140776). The Swedish Research Council (Strategic Research Area Exodiab) (https://www.vr.se/english/) via Dnr 2009-1039 and the Swedish Foundation for Strategic Research (https://strategiska.se/en/) via Dnr IRC15-0067. TVV was supported by the Novo Nordisk Foundation Postdoctoral Fellowship within Endocrinology/Metabolism at International Elite Research Environments via NNF16OC0020698. ST is supported by a career grant for clinicians from the Swedish Research Council (2019-02082).

Publisher Copyright:
© 2021, The Author(s).

Adgang til dokumentet

10.1038/s41598-021-03257-0Licens: CC BY

FulltextForlagets udgivne version, 1,16 MBLicens: CC BY

Citationsformater

A prospective study of the relationships between movement and glycemic control during day and night in pregnancy. / Behravesh, Masoud; Fernandez-Tajes, Juan; Estampador, Angela C.; Varga, Tibor V.; Gunnarsson, Ómar S.; Strevens, Helena; Timpka, Simon; Franks, Paul W.

I: Scientific Reports, Bind 11, Nr. 1, 23911, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Both disturbed sleep and lack of exercise can disrupt metabolism in pregnancy. Accelerometery was used to objectively assess movement during waking (physical activity) and movement during sleeping (sleep disturbance) periods and evaluated relationships with continuous blood glucose variation during pregnancy. Data was analysed prospectively. 15-women without pre-existing diabetes mellitus wore continuous glucose monitors and triaxial accelerometers from February through June 2018 in Sweden. The relationships between physical activity and sleep disturbance with blood glucose rate of change were assessed. An interaction term was fitted to determine difference in the relationship between movement and glucose variation, conditional on waking/sleeping. Total movement was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.037, − 0.026)). Stratified analyses showed total physical activity was inversely related to glucose rate of change (p < 0.001, 95% CI (− 0.040, − 0.028)), whereas sleep disturbance was not related to glucose rate of change (p = 0.07, 95% CI (< − 0.001, 0.013)). The interaction term was positively related to glucose rate of change (p < 0.001, 95% CI (0.029, 0.047)). This study provides temporal evidence of a relationship between total movement and glycemic control in pregnancy, which is conditional on time of day. Movement is beneficially related with glycemic control while awake, but not during sleep.",

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