Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Fertility and Sterility |
| Vol/bind | 91 |
| Udgave nummer | 3 |
| Sider (fra-til) | 842-50 |
| Antal sider | 8 |
| ISSN | 0015-0282 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adiponectin; Androsterone; Blood Glucose; Denmark; Etiocholanolone; Fatty Acids, Nonesterified; Female; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Testosterone; Testosterone 5-alpha-Reductase; Tetrahydrocortisol; Thiazolidinediones; Time Factors; Treatment OutcomeAdgang til dokumentet
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A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome. / Glintborg, Dorte; Hermann, Anne Pernille; Hagen, Claus; Jensen, Lars Thorbjørn; Frystyk, Jan; Bennett, Paul; Flyvbjerg, Allan; Andersen, Marianne.
I: Fertility and Sterility, Bind 91, Nr. 3, 2009, s. 842-50.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome
AU - Glintborg, Dorte
AU - Hermann, Anne Pernille
AU - Hagen, Claus
AU - Jensen, Lars Thorbjørn
AU - Frystyk, Jan
AU - Bennett, Paul
AU - Flyvbjerg, Allan
AU - Andersen, Marianne
N1 - Keywords: Adiponectin; Androsterone; Blood Glucose; Denmark; Etiocholanolone; Fatty Acids, Nonesterified; Female; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Testosterone; Testosterone 5-alpha-Reductase; Tetrahydrocortisol; Thiazolidinediones; Time Factors; Treatment Outcome
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). DESIGN: Randomized placebo-controlled study. SETTING: Academic tertiary care medical center. PATIENT(S): Thirty insulin-resistant PCOS patients. INTERVENTION(S): Sixteen weeks of pioglitazone (30 mg/day) or placebo treatment. MAIN OUTCOME MEASURE(S): Twenty-four-hour 20 min integrated blood sampling for measurement of cortisol and 24 h urinary excretion of steroid metabolites. Relative 5alpha-reductase activity was evaluated by allotetrahydrocortisol (alloTHF)/THF and androsterone/etiocholanolone (A/E) ratios. Delta values denoted changes during the treatment period (16 weeks--basal). Pyridostigmine growth hormone (GH) stimulation tests were performed, and testosterone (T), dihydrotestosterone (DHT), DHEA, DHEAS, adiponectin, and insulin-like growth factor I (IGF-I) were measured before and after intervention. RESULT(S): Insulin sensitivity, GH, adiponectin, and IGF-I significantly increased during pioglitazone treatment, whereas alloTHF/THF levels significantly decreased. Delta alloTHF/THF levels inversely correlated with Delta adiponectin levels. Delta A/E ratio inversely correlated with Delta IGF-I and Delta peak GH during GH stimulation tests. No significant changes were measured in T, DHT, DHEA, DHEAS, 24 h mean cortisol, or urinary excretion of steroid metabolites. CONCLUSION(S): Pioglitazone decreased relative 5alpha-reductase activity, whereas no significant changes were measured in cortisol levels or urinary cortisol excretion.
AB - OBJECTIVE: To investigate possible effects of insulin-sensitizing treatment on cortisol metabolism in insulin-resistant patients with polycystic ovary syndrome (PCOS). DESIGN: Randomized placebo-controlled study. SETTING: Academic tertiary care medical center. PATIENT(S): Thirty insulin-resistant PCOS patients. INTERVENTION(S): Sixteen weeks of pioglitazone (30 mg/day) or placebo treatment. MAIN OUTCOME MEASURE(S): Twenty-four-hour 20 min integrated blood sampling for measurement of cortisol and 24 h urinary excretion of steroid metabolites. Relative 5alpha-reductase activity was evaluated by allotetrahydrocortisol (alloTHF)/THF and androsterone/etiocholanolone (A/E) ratios. Delta values denoted changes during the treatment period (16 weeks--basal). Pyridostigmine growth hormone (GH) stimulation tests were performed, and testosterone (T), dihydrotestosterone (DHT), DHEA, DHEAS, adiponectin, and insulin-like growth factor I (IGF-I) were measured before and after intervention. RESULT(S): Insulin sensitivity, GH, adiponectin, and IGF-I significantly increased during pioglitazone treatment, whereas alloTHF/THF levels significantly decreased. Delta alloTHF/THF levels inversely correlated with Delta adiponectin levels. Delta A/E ratio inversely correlated with Delta IGF-I and Delta peak GH during GH stimulation tests. No significant changes were measured in T, DHT, DHEA, DHEAS, 24 h mean cortisol, or urinary excretion of steroid metabolites. CONCLUSION(S): Pioglitazone decreased relative 5alpha-reductase activity, whereas no significant changes were measured in cortisol levels or urinary cortisol excretion.
U2 - 10.1016/j.fertnstert.2007.12.082
DO - 10.1016/j.fertnstert.2007.12.082
M3 - Journal article
C2 - 18402944
VL - 91
SP - 842
EP - 850
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 3
ER -