Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Basic & Clinical Pharmacology & Toxicology |
| Vol/bind | 105 |
| Udgave nummer | 2 |
| Sider (fra-til) | 73-83 |
| Antal sider | 10 |
| ISSN | 1742-7835 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Catecholamines; Cholesterol; Female; Fibrinogen; Hemoglobin A, Glycosylated; Humans; Hydrocortisone; Job Satisfaction; Leadership; Male; Social Environment; Social Support; Stress, Psychological; Testosterone; WorkplaceAdgang til dokumentet
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I: Basic & Clinical Pharmacology & Toxicology, Bind 105, Nr. 2, 2009, s. 73-83.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - A review of the effect of the psychosocial working environment on physiological changes in blood and urine
AU - Hansen, Åse Marie
AU - Larsen, Ann Dyreborg
AU - Rugulies, Reiner
AU - Garde, Anne H
AU - Knudsen, Lisbeth E
N1 - Keywords: Catecholamines; Cholesterol; Female; Fibrinogen; Hemoglobin A, Glycosylated; Humans; Hydrocortisone; Job Satisfaction; Leadership; Male; Social Environment; Social Support; Stress, Psychological; Testosterone; Workplace
PY - 2009
Y1 - 2009
N2 - The aim of the present survey was to provide a literary review of current knowledge of the possible association between the psychosocial working environment and relevant physiological parameters measured in blood and urine. Literature databases (PubMed, Toxline, Biosis and Embase) were screened using the key words job, work-related and stress in combination with selected physiological parameters. In total, 51 work place studies investigated the associations between the psychosocial working environment and physiological changes, of which 20 were longitudinal studies and 12 population-based studies. The studied exposures in work place/population-based studies included: job demands (26/8 studies), job control (24/10 studies), social support and/or leadership behaviour (12/3 studies), effort-reward imbalance (three/one studies), occupational changes (four studies), shift work (eight studies), traumatic events (one study) and other (five studies). The physiological responses were catecholamines (adrenaline, noradrenaline) (14 studies), cortisol (28 studies), cholesterol (23 studies), glycated haemoglobinA(1c) (six studies), testosterone (nine studies), oestrogens (three studies), dehydroepiandrosterone (six studies), prolactin (14 studies), melatonin (one study), thyroxin (one study), immunoglobulin (Ig) A (five studies), IgG (four studies), IgM (one study) and fibrinogen (eight studies). In general, fibrinogen and catabolic indicators, defined as energy releasing, were increased, whereas the anabolic indicators defined as constructive building up energy resources were decreased when the psychosocial working environment was perceived as poor. In conclusion, in this review the association between an adverse psychosocial working environment and HbA(1c), testosterone and fibrinogen in serum was found to be a robust and potential candidate for a physiological effect of the psychosocial working environment. Further, urinary catecholamines appear to reflect the effects of shift work and monotonous work.
AB - The aim of the present survey was to provide a literary review of current knowledge of the possible association between the psychosocial working environment and relevant physiological parameters measured in blood and urine. Literature databases (PubMed, Toxline, Biosis and Embase) were screened using the key words job, work-related and stress in combination with selected physiological parameters. In total, 51 work place studies investigated the associations between the psychosocial working environment and physiological changes, of which 20 were longitudinal studies and 12 population-based studies. The studied exposures in work place/population-based studies included: job demands (26/8 studies), job control (24/10 studies), social support and/or leadership behaviour (12/3 studies), effort-reward imbalance (three/one studies), occupational changes (four studies), shift work (eight studies), traumatic events (one study) and other (five studies). The physiological responses were catecholamines (adrenaline, noradrenaline) (14 studies), cortisol (28 studies), cholesterol (23 studies), glycated haemoglobinA(1c) (six studies), testosterone (nine studies), oestrogens (three studies), dehydroepiandrosterone (six studies), prolactin (14 studies), melatonin (one study), thyroxin (one study), immunoglobulin (Ig) A (five studies), IgG (four studies), IgM (one study) and fibrinogen (eight studies). In general, fibrinogen and catabolic indicators, defined as energy releasing, were increased, whereas the anabolic indicators defined as constructive building up energy resources were decreased when the psychosocial working environment was perceived as poor. In conclusion, in this review the association between an adverse psychosocial working environment and HbA(1c), testosterone and fibrinogen in serum was found to be a robust and potential candidate for a physiological effect of the psychosocial working environment. Further, urinary catecholamines appear to reflect the effects of shift work and monotonous work.
U2 - 10.1111/j.1742-7843.2009.00444.x
DO - 10.1111/j.1742-7843.2009.00444.x
M3 - Journal article
C2 - 19563453
SN - 1742-7835
VL - 105
SP - 73
EP - 83
JO - Basic & Clinical Pharmacology & Toxicology
JF - Basic & Clinical Pharmacology & Toxicology
IS - 2
ER -