A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein

Thomas Broeng Ejsing; Niels Morling; Kristian Linnet

A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein

Thomas Broeng Ejsing, Niels Morling, Kristian Linnet

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

6 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007

Originalsprog	Engelsk
Tidsskrift	Drug Metabolism and Drug Interactions
Vol/bind	22
Udgave nummer	2-3
Sider (fra-til)	113-29
Antal sider	16
ISSN	0792-5077
Status	Udgivet - 2007

Bibliografisk note

Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship

Citationsformater

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title = "A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein",

abstract = "This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.",

author = "Ejsing, {Thomas Broeng} and Niels Morling and Kristian Linnet",

note = "Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship",

year = "2007",

language = "English",

volume = "22",

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journal = "Drug Metabolism and Drug Interactions",

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TY - JOUR

T1 - A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein

AU - Ejsing, Thomas Broeng

AU - Morling, Niels

AU - Linnet, Kristian

N1 - Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship

PY - 2007

Y1 - 2007

N2 - This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.

AB - This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.

M3 - Journal article

C2 - 17708063

SN - 0792-5077

VL - 22

SP - 113

EP - 129

JO - Drug Metabolism and Drug Interactions

JF - Drug Metabolism and Drug Interactions

IS - 2-3

ER -