A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor

J D Schiønning; Jytte Overgaard Larsen; R Eide

A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor

J D Schiønning, Jytte Overgaard Larsen, R Eide

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

18 Citationer (Scopus)

Abstract

Udgivelsesdato: 1998-Aug

Originalsprog	Engelsk
Tidsskrift	Acta Neuropathologica
Vol/bind	96
Udgave nummer	2
Sider (fra-til)	185-90
Antal sider	5
ISSN	0001-6322
Status	Udgivet - 1998
Udgivet eksternt	Ja

Bibliografisk note

Keywords: Animals; Axons; Cell Count; Cell Size; Ganglia, Spinal; Gases; Male; Mercury; Nerve Fibers; Rats; Rats, Wistar; Spinal Nerve Roots; Tissue Fixation

Citationsformater

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title = "A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor",

abstract = "Although mercury vapor is known to produce tremor and peripheral neuropathy, neuropathological studies of the effects of the vapor are few in number. The aim of the present study has been to evaluate the effect of mercury vapor on the morphology of the dorsal root ganglion and the spinal nerve roots. Adult male rats were exposed to mercury vapor for 33 days. The exposed rats developed somatic signs of intoxication and became increasingly irritable. The total numbers and volumes of A- and B-cell perikarya in the dorsal root ganglia, the total number of myelinated axons in the roots, and the cross-sectional areas of axon and myelin in the nerve roots were estimated using unbiased stereological principles. The mean cross-sectional area of myelin associated with nerve fibers in dorsal nerve roots of the exposed group was significantly reduced by 20% (2P=0.014). A tendency towards a reduction was seen in axon area of myelinated nerve fibers in the dorsal nerve roots (2P=0.087) and in the total numbers and mean volume of A-cell perikarya (2P = 0.059 and 2P=0.087, respectively). No differences between the two test groups were found for any of the parameters measured in B-cells and ventral nerve roots. It is concluded that mercury vapor, in a dose sufficient to produce intoxication, induces only minor changes in dorsal root ganglion and nerve roots in rats.",

author = "Schi{\o}nning, {J D} and Larsen, {Jytte Overgaard} and R Eide",

note = "Keywords: Animals; Axons; Cell Count; Cell Size; Ganglia, Spinal; Gases; Male; Mercury; Nerve Fibers; Rats; Rats, Wistar; Spinal Nerve Roots; Tissue Fixation",

year = "1998",

language = "English",

volume = "96",

pages = "185--90",

journal = "Acta Neuropathologica",

issn = "0001-6322",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - A stereological study of dorsal root ganglion cells and nerve root fibers from rats exposed to mercury vapor

AU - Schiønning, J D

AU - Larsen, Jytte Overgaard

AU - Eide, R

N1 - Keywords: Animals; Axons; Cell Count; Cell Size; Ganglia, Spinal; Gases; Male; Mercury; Nerve Fibers; Rats; Rats, Wistar; Spinal Nerve Roots; Tissue Fixation

PY - 1998

Y1 - 1998

N2 - Although mercury vapor is known to produce tremor and peripheral neuropathy, neuropathological studies of the effects of the vapor are few in number. The aim of the present study has been to evaluate the effect of mercury vapor on the morphology of the dorsal root ganglion and the spinal nerve roots. Adult male rats were exposed to mercury vapor for 33 days. The exposed rats developed somatic signs of intoxication and became increasingly irritable. The total numbers and volumes of A- and B-cell perikarya in the dorsal root ganglia, the total number of myelinated axons in the roots, and the cross-sectional areas of axon and myelin in the nerve roots were estimated using unbiased stereological principles. The mean cross-sectional area of myelin associated with nerve fibers in dorsal nerve roots of the exposed group was significantly reduced by 20% (2P=0.014). A tendency towards a reduction was seen in axon area of myelinated nerve fibers in the dorsal nerve roots (2P=0.087) and in the total numbers and mean volume of A-cell perikarya (2P = 0.059 and 2P=0.087, respectively). No differences between the two test groups were found for any of the parameters measured in B-cells and ventral nerve roots. It is concluded that mercury vapor, in a dose sufficient to produce intoxication, induces only minor changes in dorsal root ganglion and nerve roots in rats.

AB - Although mercury vapor is known to produce tremor and peripheral neuropathy, neuropathological studies of the effects of the vapor are few in number. The aim of the present study has been to evaluate the effect of mercury vapor on the morphology of the dorsal root ganglion and the spinal nerve roots. Adult male rats were exposed to mercury vapor for 33 days. The exposed rats developed somatic signs of intoxication and became increasingly irritable. The total numbers and volumes of A- and B-cell perikarya in the dorsal root ganglia, the total number of myelinated axons in the roots, and the cross-sectional areas of axon and myelin in the nerve roots were estimated using unbiased stereological principles. The mean cross-sectional area of myelin associated with nerve fibers in dorsal nerve roots of the exposed group was significantly reduced by 20% (2P=0.014). A tendency towards a reduction was seen in axon area of myelinated nerve fibers in the dorsal nerve roots (2P=0.087) and in the total numbers and mean volume of A-cell perikarya (2P = 0.059 and 2P=0.087, respectively). No differences between the two test groups were found for any of the parameters measured in B-cells and ventral nerve roots. It is concluded that mercury vapor, in a dose sufficient to produce intoxication, induces only minor changes in dorsal root ganglion and nerve roots in rats.

M3 - Journal article

C2 - 9705135

SN - 0001-6322

VL - 96

SP - 185

EP - 190

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 2

ER -