A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

Tue Heesgaard Jepsen, Emil Glibstrup, Francois Louis Jean Crestey, Anders A. Jensen, Jesper Langgaard Kristensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

6 Citationer (Scopus)
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Abstract

We report an effective synthetic protocol to access [6,6]-bicyclic lactone moieties through a regio- and stereoselective intramolecular Mizoroki–Heck cross-coupling reaction followed by a 6π-electrocyclization. This method enabled the first synthesis of the elusive CD fragment of the Erythrina alkaloid DHβE. Preliminary pharmacological evaluations support the notion that the key pharmacophores of DHβE are located in the A and B rings.
OriginalsprogEngelsk
TidsskriftBeilstein Journal of Organic Chemistry
Vol/bind13
Sider (fra-til)988-994
Antal sider7
ISSN2195-951X
DOI
StatusUdgivet - 2017

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