A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion

Anna Elisabet Jonsson, Bo Isomaa, Tiinamaija Tuomi, Jalal Taneera, Albert Salehi, Peter Nilsson, Leif Groop, Valeriya Lyssenko

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    Abstract

    Two independent genome-wide association studies for type 2 diabetes in Japanese subjects have recently identified common variants in the KCNQ1 gene that are strongly associated with type 2 diabetes. Here we studied whether a common variant in KCNQ1 would influence BMI as well as insulin secretion and action and predict future type 2 diabetes in subjects from Sweden and Finland.
    OriginalsprogEngelsk
    TidsskriftDiabetes
    Vol/bind58
    Udgave nummer10
    Sider (fra-til)2409-13
    Antal sider5
    ISSN0046-0192
    DOI
    StatusUdgivet - okt. 2009

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